Nitric Oxide and Heat Shock Protein 90 Activate Soluble Guanylate Cyclase by Driving Rapid Change in Its Subunit Interactions and Heme Content

Molecular Model of a Soluble Guanylyl Cyclase Fragment Determined by Small-Angle X-ray Scattering and Chemical Cross-Linking

(2013) Bradley G. Fritz et al.   BIOCHEMISTRY

Insights into BAY 60-2770 Activation and S-Nitrosylation-Dependent Desensitization of Soluble Guanylyl Cyclase via Crystal Structures of Homologous Nostoc H-NOX Domain Complexes

(2013) Vijay Kumar et al.   BIOCHEMISTRY

Higher-order interactions bridge the nitric oxide receptor and catalytic domains of soluble guanylate cyclase

(2013) E. S. Underbakke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nitration of Hsp90 induces cell death

(2013) M. C. Franco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure, Function and Regulation of the Hsp90 Machinery

(2013) Johannes Buchner et al.   Biomedical Journal

Picosecond to Second Dynamics Reveals a Structural Transition in Clostridium botulinum NO-Sensor Triggered by the Activator BAY-41-2272

(2012) Byung-Kuk Yoo et al.   ACS Chemical Biology

Structure and Regulation of Soluble Guanylate Cyclase

(2012) Emily R. Derbyshire et al.   Annual Review of Biochemistry

The Therapeutic Target Hsp90 and Cancer Hallmarks

(2012) Yoshihiko Miyata et al.   CURRENT PHARMACEUTICAL DESIGN

Reactive oxygen and nitrogen species in pulmonary hypertension

(2012) Diana M. Tabima et al.   FREE RADICAL BIOLOGY AND MEDICINE

Heme-assistedS-Nitrosation Desensitizes Ferric Soluble Guanylate Cyclase to Nitric Oxide

(2012) Nathaniel B. Fernhoff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble guanylyl cyclase requires heat shock protein 90 for heme insertion during maturation of the NO-active enzyme

(2012) A. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidation and Loss of Heme in Soluble Guanylyl Cyclase fromManduca sexta

(2011) Bradley G. Fritz et al.   BIOCHEMISTRY

The role of Hsp90 in protein complex assembly

(2011) Taras Makhnevych et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Soluble Guanylate Cyclase as an Emerging Therapeutic Target in Cardiopulmonary Disease

(2011) Johannes-Peter Stasch et al.   CIRCULATION

Nitric Oxide and Cyclic GMP Signaling Pathway as a Focus for Drug Development

(2011) A.Y. Kots et al.   CURRENT MEDICINAL CHEMISTRY

Hsp90 interacts with inducible NO synthase client protein in its heme-free state and then drives heme insertion by an ATP-dependent process

(2011) Arnab Ghosh et al.   FASEB JOURNAL

RNA splicing in regulation of nitric oxide receptor soluble guanylyl cyclase

(2011) Iraida G. Sharina et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Binding of YC-1/BAY 41-2272 to soluble guanylate cyclase: A new perspective to the mechanism of activation

(2010) Biswajit Pal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Soluble Guanylate Cyclase Is Activated Differently by Excess NO and by YC-1: Resonance Raman Spectroscopic Evidence

(2010) Mohammed Ibrahim et al.   BIOCHEMISTRY

Thrombospondin-1 is an inhibitor of pharmacological activation of soluble guanylate cyclase

(2010) Thomas W Miller et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nitric oxide blocks cellular heme insertion into a broad range of heme proteins

(2010) Syed Mohsin Waheed et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structure of Cinaciguat (BAY 58–2667) Bound toNostocH-NOX Domain Reveals Insights into Heme-mimetic Activation of the Soluble Guanylyl Cyclase

(2010) Faye Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GAPDH regulates cellular heme insertion into inducible nitric oxide synthase

(2010) R. Chakravarti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradation

(2009) LS Hoffmann et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nitric Oxide–Independent Vasodilator Rescues Heme-Oxidized Soluble Guanylate Cyclase From Proteasomal Degradation

(2009) Sabine Meurer et al.   CIRCULATION RESEARCH

Hsp90 is regulated by a switch point in the C-terminal domain

(2009) Marco Retzlaff et al.   EMBO REPORTS

α1 Soluble Guanylyl Cyclase (sGC) Splice Forms as Potential Regulators of Human sGC Activity

(2008) Iraida G. Sharina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of YC-1 or BAY 41-2272 to Soluble Guanylyl Cyclase Induces a Geminate Phase in CO Photolysis

(2008) Xiaohui Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY