Exploring the Trypanosoma brucei Hsp83 Potential as a Target for Structure Guided Drug Design

Potent Antitrypanosomal Activities of Heat Shock Protein 90 Inhibitors In Vitro and In Vivo

(2013) Kirsten J. Meyer et al.   JOURNAL OF INFECTIOUS DISEASES

Discovery of XL888: A novel tropane-derived small molecule inhibitor of HSP90

(2012) Joerg Bussenius et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Co-Chaperone Hch1 Regulates Hsp90 Function Differently than Its Homologue Aha1 and Confers Sensitivity to Yeast to the Hsp90 Inhibitor NVP-AUY922

(2012) Heather Armstrong et al.   PLoS One

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Sleeping sickness

(2011) D. Malvy et al.   CLINICAL MICROBIOLOGY AND INFECTION

Development of novel drugs for human African trypanosomiasis

(2011) Reto Brun et al.   Future Microbiology

LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery

(2011) Roman A. Laskowski et al.   Journal of Chemical Information and Modeling

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

(2011) Stephen Brand et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dynamic Interaction of Hsp90 with Its Client Protein p53

(2011) Sung Jean Park et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Conformational dynamics of the molecular chaperone Hsp90

(2011) Kristin A. Krukenberg et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Mutations that increase both Hsp90 ATPase activity in vitro and Hsp90 drug resistance in vivo

(2010) Anna Zurawska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Application of Chemoproteomics to Drug Discovery: Identification of a Clinical Candidate Targeting Hsp90

(2010) Patrick Fadden et al.   CHEMISTRY & BIOLOGY

Discovery and development of Hsp90 inhibitors: a promising pathway for cancer therapy

(2010) James R Porter et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Heat Shock Protein 90 as a Drug Target against Protozoan Infections

(2010) Rani Pallavi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Repurposing Strategy Identifies Novel Synergistic Inhibitors ofPlasmodium falciparumHeat Shock Protein 90

(2010) Dea Shahinas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chemotherapy against human African trypanosomiasis: Is there a road to success?

(2010) CHRISTIAN BURRI   PARASITOLOGY

Structural Basis of the Radicicol Resistance Displayed by a Fungal Hsp90

(2009) Chrisostomos Prodromou et al.   ACS Chemical Biology

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Inhibition of HSP90 with Pochoximes: SAR and Structure-Based Insights

(2009) Sofia Barluenga et al.   CHEMBIOCHEM

Impact of heat-shock protein 90 on cancer metastasis

(2009) Shinji Tsutsumi et al.   Future Oncology

Combining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-d]pyrimidine Inhibitors of the Hsp90 Molecular Chaperone

(2009) Paul A. Brough et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active Antitumor Agents

(2009) Kenneth H. Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

TriTrypDB: a functional genomic resource for the Trypanosomatidae

(2009) Martin Aslett et al.   NUCLEIC ACIDS RESEARCH

Apoptosis caused by Hsp90 inhibitor geldanamycin in Leishmania donovani during promastigote-to-amastigote transformation stage

(2009) Qiaoli Li et al.   PARASITOLOGY RESEARCH

Hsp90 Orchestrates Stress Response Signaling Governing Fungal Drug Resistance

(2009) Leah E. Cowen   PLoS Pathogens

NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis

(2008) S. A. Eccles et al.   CANCER RESEARCH

The ATPase Cycle of the Mitochondrial Hsp90 Analog Trap1

(2008) Adriane Leskovar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Characterization of Macbecin as an Hsp90 Inhibitor#

(2008) Christine J. Martin et al.   JOURNAL OF MEDICINAL CHEMISTRY