Targeting Ribosome Biogenesis in Cancer: Lessons Learned and Way Forward

9-Aminoacridine Inhibits Ribosome Biogenesis by Targeting Both Transcription and Processing of Ribosomal RNA

(2022) Leonid Anikin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genome-wide RNAi screen identifies novel players in human 60S subunit biogenesis including key enzymes of polyamine metabolism

(2022) Kerstin Dörner et al.   NUCLEIC ACIDS RESEARCH

A high-throughput assay for directly monitoring nucleolar rRNA biogenesis

(2022) Carson J. Bryant et al.   Open Biology

Ribosome biogenesis: a central player in cancer metastasis and therapeutic resistance

(2022) Amr R. Elhamamsy et al.   CANCER RESEARCH

Nucleolar stress: From development to cancer

(2022) M.Carmen Lafita-Navarro et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Discovery and Evaluation of Novel Angular Fused Pyridoquinazolinonecarboxamides as RNA Polymerase I Inhibitors

(2022) Tony E. Dorado et al.   ACS Medicinal Chemistry Letters

Aggregation and Supramolecular Self-Assembly of Low-Energy Red Luminescent Alkynylplatinum(II) Complexes for RNA Detection, Nucleolus Imaging, and RNA Synthesis Inhibitor Screening

(2021) Angela Sin-Yee Law et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ubiquitin-mediated DNA damage response is synthetic lethal with G-quadruplex stabilizer CX-5461

(2021) Tehmina Masud et al.   Scientific Reports

The Ribosomal Gene Loci—The Power behind the Throne

(2021) Konstantin I. Panov et al.   Genes

CX-5461 Enhances the Efficacy of APR-246 via Induction of DNA Damage and Replication Stress in Triple-Negative Breast Cancer

(2021) Ashwini Makhale et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands

(2021) Madeleine Bossaert et al.   eLife

DNA Intercalators Inhibit Eukaryotic Ribosomal RNA Synthesis by Impairing the Initiation of Transcription

(2021) William J. Andrews et al.   Genes

The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output

(2021) Dimitris C. Kanellis et al.   Science Advances

Quinacrine Induces Nucleolar Stress in Treatment-Refractory Ovarian Cancer Cell Lines

(2021) Derek B. Oien et al.   Cancers

Recent Updates on Mechanisms of Resistance to 5-Fluorouracil and Reversal Strategies in Colon Cancer Treatment

(2021) Shamin Azwar et al.   Biology-Basel

RNA-interference screen for p53 regulators unveils a role of WDR75 in ribosome biogenesis

(2021) Pavel Moudry et al.   CELL DEATH AND DIFFERENTIATION

In silico methods and tools for drug discovery

(2021) Bilal Shaker et al.   COMPUTERS IN BIOLOGY AND MEDICINE

The small-molecule BMH-21 directly inhibits transcription elongation and DNA occupancy of RNA polymerase I in vivo and in vitro

(2021) Ruth Q. Jacobs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryo-EM structures of human RNA polymerase I

(2021) Agata D. Misiaszek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma

(2021) Min Pan et al.   Nature Communications

Structure of the human RNA polymerase I elongation complex

(2021) Dan Zhao et al.   Cell Discovery

Cancer-associated mutations in the ribosomal protein L5 gene dysregulate the HDM2/p53-mediated ribosome biogenesis checkpoint

(2020) Ines Oršolić et al.   ONCOGENE

The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning

(2020) Peter M. Bruno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors

(2020) Sona Hubackova et al.   Cell Death & Disease

Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age

(2020) Rita Ferreira et al.   Cells

Targeting the Human 80S Ribosome in Cancer: From Structure to Function and Drug Design for Innovative Adjuvant Therapeutic Strategies

(2020) Arnaud Gilles et al.   Cells

Actinomycin D downregulates Sox2 and improves survival in preclinical models of recurrent glioblastoma

(2020) Jessica T Taylor et al.   NEURO-ONCOLOGY

Triptolide interrupts rRNA synthesis and induces the RPL23‑MDM2‑p53 pathway to repress lung cancer cells

(2020) Juan Wang et al.   ONCOLOGY REPORTS

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

(2020) Elaine Sanij et al.   Nature Communications

Anti-Cancer Stem Cells Potentiality of an Anti-Malarial Agent Quinacrine: An Old Wine in a New Bottle

(2020) Biswajit Das et al.   Anti-Cancer Agents in Medicinal Chemistry

Nucleotide depletion reveals the impaired ribosome biogenesis checkpoint as a barrier against DNA damage

(2020) Joffrey Pelletier et al.   EMBO JOURNAL

Nucleolar RNA polymerase II drives ribosome biogenesis

(2020) Karan J. Abraham et al.   NATURE

rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461

(2020) Jinbae Son et al.   Frontiers in Cell and Developmental Biology

The nucleolus as a multiphase liquid condensate

(2020) Denis L. J. Lafontaine et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transcriptional suppression of ribosomal DNA with phase separation

(2020) Satoru Ide et al.   Science Advances

Inhibition of the de novo pyrimidine biosynthesis pathway limits ribosomal RNA transcription causing nucleolar stress in glioblastoma cells

(2020) M. Carmen Lafita-Navarro et al.   PLoS Genetics

Down-regulation of MYCN protein by CX-5461 leads to neuroblastoma tumor growth suppression

(2019) Jordan S. Taylor et al.   JOURNAL OF PEDIATRIC SURGERY

Ribosomal Proteins Control Tumor Suppressor Pathways in Response to Nucleolar Stress

(2019) Frédéric Lessard et al.   BIOESSAYS

Inhibition of RNA polymerase III transcription by Triptolide attenuates colorectal tumorigenesis

(2019) Xia Liang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Phase-to-Phase With Nucleoli – Stress Responses, Protein Aggregation and Novel Roles of RNA

(2019) Leena Latonen   Frontiers in Cellular Neuroscience

Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease

(2019) Varsha Prakash et al.   Nature Communications

First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematological Cancers: Results of a Phase I Dose Escalation Study

(2019) Amit Khot et al.   Cancer Discovery

Discovery of novel inhibitors of ribosome biogenesis by innovative high throughput screening strategies

(2019) Catherine E Scull et al.   BIOCHEMICAL JOURNAL

Inhibiting eukaryotic ribosome biogenesis

(2019) Dominik Awad et al.   BMC BIOLOGY

The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity

(2019) Jaime A. Espinoza et al.   CELL DEATH AND DIFFERENTIATION

The nucleolus: a central response hub for the stressors that drive cancer progression

(2019) Shannon E. Weeks et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting RNA Polymerase I with Hernandonine Inhibits Ribosomal RNA Synthesis and Tumor Cell Growth

(2019) Yen-Ting Chen et al.   MOLECULAR CANCER RESEARCH

IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

(2019) Satoshi Kofuji et al.   NATURE CELL BIOLOGY

Effective targeting of RNA polymerase I in treatment‐resistant prostate cancer

(2019) Jin‐Yih Low et al.   PROSTATE

The Targeting of RNA Polymerase I Transcription Using CX-5461 in Combination with Radiation Enhances Tumour Cell Killing Effects in Human Solid Cancers

(2019) Mohammed Ismael et al.   Cancers

Therapeutic Approaches Targeting Nucleolus in Cancer

(2019) Pietro Carotenuto et al.   Cells

The Nucleolus: A Multiphase Condensate Balancing Ribosome Synthesis and Translational Capacity in Health, Aging and Ribosomopathies

(2019) Carl C. Correll et al.   Cells

Nucleolar Stress Induction by Oxaliplatin and Derivatives

(2019) Emily C. Sutton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

5-fluorouracil and other fluoropyrimidines in colorectal cancer: Past, present and future

(2019) Sona Vodenkova et al.   PHARMACOLOGY & THERAPEUTICS

CETSA in integrated proteomics studies of cellular processes

(2019) Nayana Prabhu et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

CX-5461 Inhibits Pancreatic Ductal Adenocarcinoma Cell Growth, Migration and Induces DNA Damage

(2019) Btissame El Hassouni et al.   MOLECULES

ProTargetMiner as a proteome signature library of anticancer molecules for functional discovery

(2019) Amir Ata Saei et al.   Nature Communications

c-MYC G-quadruplex binding by the RNA polymerase I inhibitor BMH-21 and analogues revealed by a combined NMR and biochemical Approach

(2018) Loana Musso et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ribosome biogenesis and cancer: basic and translational challenges

(2018) Xosé R. Bustelo et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Treating hematological malignancies with drugs inhibiting ribosome biogenesis: when and why

(2018) Enrico Derenzini et al.   Journal of Hematology & Oncology

Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway

(2018) Frédéric Lessard et al.   NATURE CELL BIOLOGY

Principles for targeting RNA with drug-like small molecules

(2018) Katherine Deigan Warner et al.   NATURE REVIEWS DRUG DISCOVERY

Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis

(2018) Mikael S. Lindström et al.   ONCOGENE

Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis

(2018) Kevin J. Frankowski et al.   Science Translational Medicine

The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth

(2018) Simone Pellegrino et al.   STRUCTURE

Translational Control in Cancer

(2018) Nathaniel Robichaud et al.   Cold Spring Harbor Perspectives in Biology

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

(2018) Marcus J. G. W. Ladds et al.   Nature Communications

Diverse Regulators of Human Ribosome Biogenesis Discovered by Changes in Nucleolar Number

(2018) Katherine I. Farley-Barnes et al.   Cell Reports

Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint

(2018) Ting Wei et al.   Cell Reports

Use of the iNo score to discriminate normal from altered nucleolar morphology, with applications in basic cell biology and potential in human disease diagnostics

(2018) Vassiliki Stamatopoulou et al.   Nature Protocols

Ribosome biogenesis: An emerging druggable pathway for cancer therapeutics

(2018) Frédéric Catez et al.   BIOCHEMICAL PHARMACOLOGY

Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma

(2018) Øyvind H. Hald et al.   ONCOGENE

RAM-589.555 a new Polymerase-1 inhibitor as innovative targeted-treatment for multiple sclerosis

(2017) A Achiron et al.   JOURNAL OF NEUROIMMUNOLOGY

Novel Assay to Detect RNA Polymerase I Activity In Vivo

(2017) Gunes Guner et al.   MOLECULAR CANCER RESEARCH

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

(2017) Zdenek Skrott et al.   NATURE

A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress

(2017) Peter M Bruno et al.   NATURE MEDICINE

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

(2017) Hong Xu et al.   Nature Communications

The ribosomal protein gene RPL5 is a haploinsufficient tumor suppressor in multiple cancer types

(2017) Laura Fancello et al.   Oncotarget

Translational reprogramming of colorectal cancer cells induced by 5-fluorouracil through a miRNA-dependent mechanism

(2017) Zeina Bash-Imam et al.   Oncotarget

A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay

(2017) Mark-Anthony Bray et al.   GigaScience

The Roles of MDM2 and MDMX in Cancer

(2016) Orit Karni-Schmidt et al.   Annual Review of Pathology-Mechanisms of Disease

Pathways of cardiac toxicity: comparison between chemotherapeutic drugs doxorubicin and mitoxantrone

(2016) Roberto Marques Damiani et al.   ARCHIVES OF TOXICOLOGY

Commentary on “Participation of p53 Protein in the Cellular Response to DNA Damage”

(2016) Michael B. Kastan   CANCER RESEARCH

Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis

(2016) Shigehiro A. Kawashima et al.   CELL

Coexisting Liquid Phases Underlie Nucleolar Subcompartments

(2016) Marina Feric et al.   CELL

The Dual Inhibition of RNA Pol I Transcription and PIM Kinase as a New Therapeutic Approach to Treat Advanced Prostate Cancer

(2016) Richard J. Rebello et al.   CLINICAL CANCER RESEARCH

The stress-inducible transcription factor ATF4 accumulates at specific rRNA-processing nucleolar regions after proteasome inhibition

(2016) Valentina Galimberti et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Homoharringtonine, aclarubicin and cytarabine (HAA) regimen as the first course of induction therapy is highly effective for acute myeloid leukemia with t (8;21)

(2016) Hong-Hu Zhu et al.   LEUKEMIA RESEARCH

Investigating actinomycin D binding to G-quadruplex, i-motif and double-stranded DNA in 27-nt segment of c-MYC gene promoter

(2016) Zhila Niknezhad et al.   Materials Science & Engineering C-Materials for Biological Applications

Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes

(2016) Mark-Anthony Bray et al.   Nature Protocols

Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress

(2016) Emilien Nicolas et al.   Nature Communications

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil

(2016) Helena Almqvist et al.   Nature Communications

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

(2016) Jaclyn Quin et al.   Oncotarget

Alu element-containing RNAs maintain nucleolar structure and function

(2015) M. Caudron-Herger et al.   EMBO JOURNAL

Azide vs Alkyne Functionalization in Pt(II) Complexes for Post-treatment Click Modification: Solid-State Structure, Fluorescent Labeling, and Cellular Fate

(2015) Regina Wirth et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct relationship between the level of p53 stabilization induced by rRNA synthesis-inhibiting drugs and the cell ribosome biogenesis rate

(2015) F Scala et al.   ONCOGENE

Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia

(2015) A Eriksson et al.   Blood Cancer Journal

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma

(2015) J. R. Devlin et al.   Cancer Discovery

Targeted cancer therapy with ribosome biogenesis inhibitors: a real possibility?

(2015) Elisa Brighenti et al.   Oncotarget

Depletion of the cisplatin targeted HMGB-box factor UBF selectively induces p53-independent apoptotic death in transformed cells

(2015) Nourdine Hamdane et al.   Oncotarget

rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis

(2015) Sandeep S. Negi et al.   Oncotarget

Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells

(2015) Lukas Badertscher et al.   Cell Reports

DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response

(2015) Laureen Colis et al.   Oncotarget

Targeting the nucleolus for cancer intervention

(2014) Jaclyn E. Quin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A Targeting Modality for Destruction of RNA Polymerase I that Possesses Anticancer Activity

(2014) Karita Peltonen et al.   CANCER CELL

Non-genotoxic activation of p53 through the RPL11-dependent ribosomal stress pathway

(2014) Lucia Morgado-Palacin et al.   CARCINOGENESIS

Rapamycin: One Drug, Many Effects

(2014) Jing Li et al.   Cell Metabolism

p53 and ribosome biogenesis stress: The essentials

(2014) Lior Golomb et al.   FEBS LETTERS

Selective Inhibition of rDNA Transcription by a Small-Molecule Peptide That Targets the Interface between RNA Polymerase I and Rrn3

(2014) Katrina Rothblum et al.   MOLECULAR CANCER RESEARCH

Small Molecule BMH-Compounds That Inhibit RNA Polymerase I and Cause Nucleolar Stress

(2014) K. Peltonen et al.   MOLECULAR CANCER THERAPEUTICS

Nucleolar stress with and without p53

(2014) Allison James et al.   Nucleus

The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death

(2013) Shuxi Qiao et al.   Autophagy

Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis

(2013) Sladana Bursac et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Functional ribosome biogenesis is a prerequisite for p53 destabilization: impact of chemotherapy on nucleolar functions and RNA metabolism

(2013) Kaspar Burger et al.   BIOLOGICAL CHEMISTRY

The Cell’s Nucleolus: an Emerging Target for Chemotherapeutic Intervention

(2013) Amanda J. Pickard et al.   ChemMedChem

Targeting the nucleolus for cancer-specific activation of p53

(2013) Denis Drygin et al.   DRUG DISCOVERY TODAY

Cyclin-dependent Kinase 9 Links RNA Polymerase II Transcription to Processing of Ribosomal RNA

(2013) Kaspar Burger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Drug Diazaborine Blocks Ribosome Biogenesis by Inhibiting the AAA-ATPase Drg1

(2013) Mathias Loibl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Old Drug, New Target

(2013) William J. Andrews et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eukaryotic ribosome biogenesis at a glance

(2013) E. Thomson et al.   JOURNAL OF CELL SCIENCE

The Complexity of Human Ribosome Biogenesis Revealed by Systematic Nucleolar Screening of Pre-rRNA Processing Factors

(2013) Lionel Tafforeau et al.   MOLECULAR CELL

Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation

(2013) Swagat Ray et al.   Nature Communications

Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin

(2013) Baoxu Pang et al.   Nature Communications

5S Ribosomal RNA Is an Essential Component of a Nascent Ribosomal Precursor Complex that Regulates the Hdm2-p53 Checkpoint

(2013) Giulio Donati et al.   Cell Reports

The 5S RNP Couples p53 Homeostasis to Ribosome Biogenesis and Nucleolar Stress

(2013) Katherine E. Sloan et al.   Cell Reports

Roles of the mammalian target of rapamycin, mTOR, in controlling ribosome biogenesis and protein synthesis: Figure 1

(2012) Valentina Iadevaia et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Natural Product Triptolide Mediates Cancer Cell Death by Triggering CDK7-Dependent Degradation of RNA Polymerase II

(2012) S. G. Manzo et al.   CANCER RESEARCH

Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics

(2012) Mustapha Haddach et al.   ACS Medicinal Chemistry Letters

p53 -Dependent and -Independent Nucleolar Stress Responses

(2012) Karl Holmberg Olausson et al.   Cells

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers

(2011) Reza Ehsanian et al.   Cell Communication and Signaling

Selective inhibition of rRNA transcription downregulates E2F-1: a new p53-independent mechanism linking cell growth to cell proliferation

(2011) Giulio Donati et al.   JOURNAL OF CELL SCIENCE

Nucleolar disruption and apoptosis are distinct neuronal responses to etoposide-induced DNA damage

(2011) Maciej Pietrzak et al.   JOURNAL OF NEUROCHEMISTRY

XPB, a subunit of TFIIH, is a target of the natural product triptolide

(2011) Denis V Titov et al.   Nature Chemical Biology

Triptolide (TPL) Inhibits Global Transcription by Inducing Proteasome-Dependent Degradation of RNA Polymerase II (Pol II)

(2011) Ying Wang et al.   PLoS One

The Role of p53 in Ribosomopathies

(2011) Stefano Fumagalli et al.   SEMINARS IN HEMATOLOGY

The RNA Polymerase I Transcription Machinery: An Emerging Target for the Treatment of Cancer

(2010) Denis Drygin et al.   Annual Review of Pharmacology and Toxicology

An ARF-Independent c-MYC-Activated Tumor Suppression Pathway Mediated by Ribosomal Protein-Mdm2 Interaction

(2010) Everardo Macias et al.   CANCER CELL

Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth

(2010) Denis Drygin et al.   CANCER RESEARCH

Mitomycin C Inhibits Ribosomal RNA

(2010) Ryan G. Snodgrass et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemotherapeutic Drugs Inhibit Ribosome Biogenesis at Various Levels

(2010) Kaspar Burger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability

(2010) L Latonen et al.   ONCOGENE

Identification of Novel p53 Pathway Activating Small-Molecule Compounds Reveals Unexpected Similarities with Known Therapeutic Agents

(2010) Karita Peltonen et al.   PLoS One

The Nucleolus

(2010) T. Pederson   Cold Spring Harbor Perspectives in Biology

Transcriptional Regulation by P53

(2010) R. Beckerman et al.   Cold Spring Harbor Perspectives in Biology

High prevalence of retinoblastoma protein loss in triple-negative breast cancers and its association with a good prognosis in patients treated with adjuvant chemotherapy

(2009) D. Trere et al.   ANNALS OF ONCOLOGY

Novel Molecular Mechanism for Actinomycin D Activity as an Oncogenic Promoter G-Quadruplex Binder

(2009) Hyun-Jin Kang et al.   BIOCHEMISTRY

Interactions of Actinomycin D with Human Telomeric G-Quadruplex DNA

(2009) Jason S. Hudson et al.   BIOCHEMISTRY

The Role of Myc-Induced Protein Synthesis in Cancer

(2009) D. Ruggero   CANCER RESEARCH

Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis

(2009) D. Drygin et al.   CANCER RESEARCH

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction

(2009) Stefano Fumagalli et al.   NATURE CELL BIOLOGY

Nucleolus, Ribosomes, and Cancer

(2008) Lorenzo Montanaro et al.   AMERICAN JOURNAL OF PATHOLOGY

Loss of Retinoblastoma Tumor Suppressor Protein Makes Human Breast Cancer Cells More Sensitive to Antimetabolite Exposure

(2008) M. Derenzini et al.   CLINICAL CANCER RESEARCH

Mycophenolic Acid Activation of p53 Requires Ribosomal Proteins L5 and L11

(2008) Xiao-Xin Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY