Structure of the human RNA polymerase I elongation complex

Highly accurate protein structure prediction for the human proteome

(2021) Kathryn Tunyasuvunakool et al.   NATURE

Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age

(2020) Rita Ferreira et al.   Cells

Nascent Transcript Folding Plays a Major Role in Determining RNA Polymerase Elongation Rates

(2020) Tomasz W. Turowski et al.   MOLECULAR CELL

Transcriptional suppression of ribosomal DNA with phase separation

(2020) Satoru Ide et al.   Science Advances

The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2

(2019) Lucas Tafur et al.   eLife

POLR1B and neural crest cell anomalies in Treacher Collins syndrome type 4

(2019) Elodie Sanchez et al.   GENETICS IN MEDICINE

Molecular insight into RNA polymerase I promoter recognition and promoter melting

(2019) Yashar Sadian et al.   Nature Communications

Regulation of RNA Polymerase I TranscriptioninDevelopment, Disease, and Aging

(2018) Samim Sharifi et al.   Annual Review of Biochemistry

tp53-dependent and independent signaling underlies the pathogenesis and possible prevention of Acrofacial Dysostosis–Cincinnati type

(2018) Kristin E N Watt et al.   HUMAN MOLECULAR GENETICS

Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint

(2018) Ting Wei et al.   Cell Reports

Structural basis of RNA polymerase I stalling at UV light-induced DNA damage

(2018) Marta Sanz-Murillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Severe neurodegenerative disease in brothers with homozygous mutation in POLR1A

(2017) Bülent Kara et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Molecular Structures of Transcribing RNA Polymerase I

(2016) Lucas Tafur et al.   MOLECULAR CELL

Structure of RNA polymerase I transcribing ribosomal DNA genes

(2016) Simon Neyer et al.   NATURE

Mechanisms of backtrack recovery by RNA polymerases I and II

(2016) Ana Lisica et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue

(2016) Lin-Tai Da et al.   Nature Communications

Structure of the initiation-competent RNA polymerase I and its implication for transcription

(2016) Michael Pilsl et al.   Nature Communications

The Roles of RNA Polymerase I and III Subunits Polr1c and Polr1d in Craniofacial Development and in Zebrafish Models of Treacher Collins Syndrome

(2016) Kristin E. Noack Watt et al.   PLoS Genetics

Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2

(2016) Dari Kimanius et al.   eLife

Acrofacial Dysostosis, Cincinnati Type, a Mandibulofacial Dysostosis Syndrome with Limb Anomalies, Is Caused by POLR1A Dysfunction

(2015) K. Nicole Weaver et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Three-dimensional structure of human γ-secretase

(2014) Peilong Lu et al.   NATURE

Structure of the Yeast Mitochondrial Large Ribosomal Subunit

(2014) A. Amunts et al.   SCIENCE

Ribosomal DNA copy number is coupled with gene expression variation and mitochondrial abundance in humans

(2014) John G. Gibbons et al.   Nature Communications

Ribosome Biogenesis in the Yeast Saccharomyces cerevisiae

(2013) John L. Woolford et al.   GENETICS

DNA Binding by the Ribosomal DNA Transcription Factor Rrn3 Is Essential for Ribosomal DNA Transcription

(2013) Ann Stepanchick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the 14-subunit RNA polymerase I

(2013) Carlos Fernández-Tornero et al.   NATURE

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Conservation between the RNA Polymerase I, II, and III Transcription Initiation Machineries

(2012) Alessandro Vannini et al.   MOLECULAR CELL

Structural basis of initial RNA polymerase II transcription

(2011) Alan C M Cheung et al.   EMBO JOURNAL

RNA polymerase I activity is regulated at multiple steps in the transcription cycle: Recent insights into factors that influence transcription elongation

(2011) David Alan Schneider   GENE

RNA polymerase I–specific subunits promote polymerase clustering to enhance the rRNA gene transcription cycle

(2011) Benjamin Albert et al.   JOURNAL OF CELL BIOLOGY

Structural basis of RNA polymerase II backtracking, arrest and reactivation

(2011) Alan C. M. Cheung et al.   NATURE

The RNA Polymerase I Transcription Machinery: An Emerging Target for the Treatment of Cancer

(2010) Denis Drygin et al.   Annual Review of Pharmacology and Toxicology

RNA Polymerase I Contains a TFIIF-Related DNA-Binding Subcomplex

(2010) Sebastian R. Geiger et al.   MOLECULAR CELL

Mutations in genes encoding subunits of RNA polymerases I and III cause Treacher Collins syndrome

(2010) Johannes G Dauwerse et al.   NATURE GENETICS

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural Basis of Transcription: Mismatch-Specific Fidelity Mechanisms and Paused RNA Polymerase II with Frayed RNA

(2009) Jasmin F. Sydow et al.   MOLECULAR CELL

Structural Basis of Transcription: Backtracked RNA Polymerase II at 3.4 Angstrom Resolution

(2009) D. Wang et al.   SCIENCE

The Epigenetics of rRNA Genes: From Molecular to Chromosome Biology

(2008) Brian McStay et al.   Annual Review of Cell and Developmental Biology

RNA polymerases I and III, non-coding RNAs and cancer

(2008) Robert J. White   TRENDS IN GENETICS