IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers

(2018) Fang Huang et al.   Cell Metabolism

The redox requirements of proliferating mammalian cells

(2018) Aaron M. Hosios et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival

(2018) Megumi Shiota et al.   Nature Communications

Purine synthesis promotes maintenance of brain tumor initiating cells in glioma

(2017) Xiuxing Wang et al.   NATURE NEUROSCIENCE

Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase

(2017) Natasha Emmanuel et al.   Cell Reports

Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism

(2017) James R. Krycer et al.   Cell Reports

Organotypic brain explant culture as a drug evaluation system for malignant brain tumors

(2017) Noriaki Minami et al.   Cancer Medicine

At the Crossroads of Cancer Stem Cells, Radiation Biology, and Radiation Oncology

(2016) L. E. Gerweck et al.   CANCER RESEARCH

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis

(2016) Kazutaka Sumita et al.   MOLECULAR CELL

GlioVis data portal for visualization and analysis of brain tumor expression datasets

(2016) Robert L. Bowman et al.   NEURO-ONCOLOGY

Differential localization of glioblastoma subtype: implications on glioblastoma pathogenesis

(2016) Tyler C. Steed et al.   Oncotarget

Regulation of ribosomal RNA synthesis in T cells: requirement for GTP and Ebp1

(2015) L. X. T. Nguyen et al.   BLOOD

Effects of processing and storage conditions on charged metabolomic profiles in blood

(2015) Akiyoshi Hirayama et al.   ELECTROPHORESIS

Cancer stem cells in glioblastoma

(2015) Justin D. Lathia et al.   GENES & DEVELOPMENT

Invasion Precedes Tumor Mass Formation in a Malignant Brain Tumor Model of Genetically Modified Neural Stem Cells

(2015) Oltea Sampetrean et al.   NEOPLASIA

Most Human Non-GCIMP Glioblastoma Subtypes Evolve from a Common Proneural-like Precursor Glioma

(2014) Tatsuya Ozawa et al.   CANCER CELL

A Targeting Modality for Destruction of RNA Polymerase I that Possesses Anticancer Activity

(2014) Karita Peltonen et al.   CANCER CELL

Connecting the nucleolus to the cell cycle and human disease

(2014) Robert Y. L. Tsai et al.   FASEB JOURNAL

Metabolomics of Human Brain Aging and Age-Related Neurodegenerative Diseases

(2014) Mariona Jové et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

What do we know about IDH1/2 mutations so far, and how do we use it?

(2013) Craig Horbinski   ACTA NEUROPATHOLOGICA

The nucleolus—guardian of cellular homeostasis and genome integrity

(2013) Ingrid Grummt   CHROMOSOMA

Analysis of Tumor Metabolism Reveals Mitochondrial Glucose Oxidation in Genetically Diverse Human Glioblastomas in the Mouse Brain In Vivo

(2012) Isaac Marin-Valencia et al.   Cell Metabolism

Ubiquitin- and MDM2 E3 Ligase-independent Proteasomal Turnover of Nucleostemin in Response to GTP Depletion

(2012) Dorothy Lo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Revisiting the Nucleolus: From Marker to Dynamic Integrator of Cancer Signaling

(2012) D. Ruggero   Science Signaling

Glioblastoma: From Molecular Pathology to Targeted Treatment

(2011) Timothy F. Cloughesy et al.   Annual Review of Pathology-Mechanisms of Disease

Cooperativity within and among Pten, p53, and Rb Pathways Induces High-Grade Astrocytoma in Adult Brain

(2011) Lionel M.L. Chow et al.   CANCER CELL

The RNA Polymerase I Transcription Machinery: An Emerging Target for the Treatment of Cancer

(2010) Denis Drygin et al.   Annual Review of Pharmacology and Toxicology

Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth

(2010) Denis Drygin et al.   CANCER RESEARCH

Adenine, guanine and pyridine nucleotides in blood during physical exercise and restitution in healthy subjects

(2010) W. Dudzinska et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Mycophenolic Acid (Cellcept and Myofortic) Induced Injury of the Upper GI Tract

(2009) Thong Nguyen et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Metabolomic Profiling of Anionic Metabolites by Capillary Electrophoresis Mass Spectrometry

(2009) Tomoyoshi Soga et al.   ANALYTICAL CHEMISTRY

Stressing Out over tRNA Cleavage

(2009) Debrah M. Thompson et al.   CELL

IMP Dehydrogenase: Structure, Mechanism, and Inhibition

(2009) Lizbeth Hedstrom   CHEMICAL REVIEWS

Pten Haploinsufficiency Accelerates Formation of High-Grade Astrocytomas

(2008) C.-H. Kwon et al.   CANCER RESEARCH

Global Regulation of Nucleotide Biosynthetic Genes by c-Myc

(2008) Yen-Chun Liu et al.   PLoS One

Guanine nucleotide depletion inhibits pre-ribosomal RNA synthesis and causes nucleolar disruption

(2007) Min Huang et al.   LEUKEMIA RESEARCH