The small-molecule BMH-21 directly inhibits transcription elongation and DNA occupancy of RNA polymerase I in vivo and in vitro

Spt4 Promotes Pol I Processivity and Transcription Elongation

(2021) Abigail K. Huffines et al.   Genes

DNA Intercalators Inhibit Eukaryotic Ribosomal RNA Synthesis by Impairing the Initiation of Transcription

(2021) William J. Andrews et al.   Genes

The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning

(2020) Peter M. Bruno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age

(2020) Rita Ferreira et al.   Cells

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

(2020) Elaine Sanij et al.   Nature Communications

Transcription and Translation Inhibitors in Cancer Treatment

(2020) Nihay Laham-Karam et al.   Frontiers in Chemistry

A novel assay for RNA polymerase I transcription elongation sheds light on the evolutionary divergence of eukaryotic RNA polymerases

(2019) Catherine E Scull et al.   BIOCHEMISTRY

First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematological Cancers: Results of a Phase I Dose Escalation Study

(2019) Amit Khot et al.   Cancer Discovery

Inhibiting eukaryotic ribosome biogenesis

(2019) Dominik Awad et al.   BMC BIOLOGY

Coordinated Control of rRNA Processing by RNA Polymerase I

(2019) Catherine E. Scull et al.   TRENDS IN GENETICS

The Targeting of RNA Polymerase I Transcription Using CX-5461 in Combination with Radiation Enhances Tumour Cell Killing Effects in Human Solid Cancers

(2019) Mohammed Ismael et al.   Cancers

CX-5461 Inhibits Pancreatic Ductal Adenocarcinoma Cell Growth, Migration and Induces DNA Damage

(2019) Btissame El Hassouni et al.   MOLECULES

Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis

(2018) Kevin J. Frankowski et al.   Science Translational Medicine

Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint

(2018) Ting Wei et al.   Cell Reports

CX-5461-loaded nucleolus-targeting nanoplatform for cancer therapy through induction of pro-death autophagy

(2018) Yanhong Duo et al.   Acta Biomaterialia

Ribosome biogenesis: An emerging druggable pathway for cancer therapeutics

(2018) Frédéric Catez et al.   BIOCHEMICAL PHARMACOLOGY

NETSeq reveals heterogeneous nucleotide incorporation by RNA polymerase I

(2018) Andrew M. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

(2017) Hong Xu et al.   Nature Communications

Roles of eukaryotic topoisomerases in transcription, replication and genomic stability

(2016) Yves Pommier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CX-5461 induces autophagy and inhibits tumor growth via mammalian target of rapamycin-related signaling pathways in osteosarcoma

(2016) Xu Li et al.   OncoTargets and Therapy

DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response

(2015) Laureen Colis et al.   Oncotarget

A Targeting Modality for Destruction of RNA Polymerase I that Possesses Anticancer Activity

(2014) Karita Peltonen et al.   CANCER CELL

Targeting RNA polymerase I transcription and the nucleolus for cancer therapy

(2013) Ross D Hannan et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

RNA polymerase I structure and transcription regulation

(2013) Christoph Engel et al.   NATURE

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

(2012) Megan J. Bywater et al.   CANCER CELL

A map of nucleosome positions in yeast at base-pair resolution

(2012) Kristin Brogaard et al.   NATURE

Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics

(2012) Mustapha Haddach et al.   ACS Medicinal Chemistry Letters

Establishment and Maintenance of Alternative Chromatin States at a Multicopy Gene Locus

(2011) Manuel Wittner et al.   CELL

Linking RNA Polymerase Backtracking to Genome Instability in E. coli

(2011) Dipak Dutta et al.   CELL

Efficient transcription by RNA polymerase I using recombinant core factor

(2011) Gregory J. Bedwell et al.   GENE

Nascent transcript sequencing visualizes transcription at nucleotide resolution

(2011) L. Stirling Churchman et al.   NATURE

The RNA Polymerase I Transcription Machinery: An Emerging Target for the Treatment of Cancer

(2010) Denis Drygin et al.   Annual Review of Pharmacology and Toxicology

Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth

(2010) Denis Drygin et al.   CANCER RESEARCH

Chemotherapeutic Drugs Inhibit Ribosome Biogenesis at Various Levels

(2010) Kaspar Burger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Yeast Pre-rRNA Processing and Modification Occur Cotranscriptionally

(2010) Martin Koš et al.   MOLECULAR CELL

Identification of Novel p53 Pathway Activating Small-Molecule Compounds Reveals Unexpected Similarities with Known Therapeutic Agents

(2010) Karita Peltonen et al.   PLoS One

Visual Analysis of the Yeast 5S rRNA Gene Transcriptome: Regulation and Role of La Protein

(2008) S. L. French et al.   MOLECULAR AND CELLULAR BIOLOGY