9-Aminoacridine Inhibits Ribosome Biogenesis by Targeting Both Transcription and Processing of Ribosomal RNA

DNA Intercalators Inhibit Eukaryotic Ribosomal RNA Synthesis by Impairing the Initiation of Transcription

(2021) William J. Andrews et al.   Genes

Quinacrine Induces Nucleolar Stress in Treatment-Refractory Ovarian Cancer Cell Lines

(2021) Derek B. Oien et al.   Cancers

The small-molecule BMH-21 directly inhibits transcription elongation and DNA occupancy of RNA polymerase I in vivo and in vitro

(2021) Ruth Q. Jacobs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CX-5461 Treatment Leads to Cytosolic DNA-Mediated STING Activation in Ovarian Cancer

(2021) Robert Cornelison et al.   Cancers

Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age

(2020) Rita Ferreira et al.   Cells

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

(2020) Elaine Sanij et al.   Nature Communications

A new look at 9‐substituted acridines with various biological activities

(2020) Maria Kozurkova et al.   JOURNAL OF APPLIED TOXICOLOGY

Ribosomopathies: Old Concepts, New Controversies

(2019) Katherine I. Farley-Barnes et al.   TRENDS IN GENETICS

Therapeutic Approaches Targeting Nucleolus in Cancer

(2019) Pietro Carotenuto et al.   Cells

Dynamic regulation of nucleolar architecture

(2018) Attila Németh et al.   CURRENT OPINION IN CELL BIOLOGY

Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint

(2018) Ting Wei et al.   Cell Reports

Medicinal chemistry of acridine and its analogues

(2018) Parteek Prasher et al.   MedChemComm

Ribosome biogenesis: An emerging druggable pathway for cancer therapeutics

(2018) Frédéric Catez et al.   BIOCHEMICAL PHARMACOLOGY

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

(2017) Hong Xu et al.   Nature Communications

Inhibition of post-transcriptional steps in ribosome biogenesis confers cytoprotection against chemotherapeutic agents in a p53-dependent manner

(2017) Russell T. Sapio et al.   Scientific Reports

Ribosomopathies: how a common root can cause a tree of pathologies

(2015) Nadia Danilova et al.   Disease Models & Mechanisms

Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia

(2015) A Eriksson et al.   Blood Cancer Journal

Targeted cancer therapy with ribosome biogenesis inhibitors: a real possibility?

(2015) Elisa Brighenti et al.   Oncotarget

Targeting the nucleolus for cancer intervention

(2014) Jaclyn E. Quin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A Targeting Modality for Destruction of RNA Polymerase I that Possesses Anticancer Activity

(2014) Karita Peltonen et al.   CANCER CELL

Non-genotoxic activation of p53 through the RPL11-dependent ribosomal stress pathway

(2014) Lucia Morgado-Palacin et al.   CARCINOGENESIS

p53 and ribosome biogenesis stress: The essentials

(2014) Lior Golomb et al.   FEBS LETTERS

Small Molecule BMH-Compounds That Inhibit RNA Polymerase I and Cause Nucleolar Stress

(2014) K. Peltonen et al.   MOLECULAR CANCER THERAPEUTICS

Combination of 9-aminoacridine with Campath-1H provides effective therapy for a murine model of adult T-cell leukemia

(2014) Wei Ju et al.   Retrovirology

An overview of pre-ribosomal RNA processing in eukaryotes

(2014) Anthony K. Henras et al.   Wiley Interdisciplinary Reviews-RNA

The nucleolus: an emerging target for cancer therapy

(2013) Nadine Hein et al.   TRENDS IN MOLECULAR MEDICINE

Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers

(2011) Reza Ehsanian et al.   Cell Communication and Signaling

Quinacrine has anticancer activity in breast cancer cells through inhibition of topoisomerase activity

(2011) Ranjan Preet et al.   INTERNATIONAL JOURNAL OF CANCER

Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth

(2010) Denis Drygin et al.   CANCER RESEARCH

Polyadenylation and degradation of incomplete RNA polymerase I transcripts in mammalian cells

(2010) Natalia Shcherbik et al.   EMBO REPORTS

5′-end surveillance by Xrn2 acts as a shared mechanism for mammalian pre-rRNA maturation and decay

(2010) Minshi Wang et al.   NUCLEIC ACIDS RESEARCH

Signaling to p53: Ribosomal Proteins Find Their Way

(2009) Yanping Zhang et al.   CANCER CELL

9-Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF-κB and p53 pathways

(2009) C Guo et al.   ONCOGENE

Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II

(2008) Lisa M. Oppegard et al.   EUROPEAN JOURNAL OF PHARMACOLOGY