Article
Biochemistry & Molecular Biology
Chun Hua Piao, Yanjing Fan, Thi Van Nguyen, Hee Soon Shin, Hyoung Tae Kim, Chang Ho Song, Ok Hee Chai
Summary: This study found that PM2.5 exposure may exacerbate allergic rhinitis in mice by enhancing inflammatory cell expression and oxidative stress. Additionally, PM2.5 exposure could increase histopathological changes in nasal and lung tissues, while inhibiting the activity of the Nrf2 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Sergio Davinelli, Luciano Saso, Floriana D'Angeli, Vittorio Calabrese, Mariano Intrieri, Giovanni Scapagnini
Summary: This article reviews the potential molecular mechanisms by which astaxanthin (AST) regulates the transcription factors Nrf2 and NF-κB, which are involved in oxidative stress and inflammation. Additionally, it summarizes the current clinical studies elucidating how AST alleviates the etiopathogenesis of oxidative stress and inflammation.
Review
Cell Biology
Don A. Davies, Aida Adlimoghaddam, Benedict C. Albensi
Summary: Nrf2 impairments in neurodegenerative disorders, such as Alzheimer's disease, lead to oxidative stress, while Nrf2 activators can reverse memory and synaptic plasticity impairments associated with AD.
Review
Biochemistry & Molecular Biology
Sonia Emanuele, Adriana Celesia, Antonella D'Anneo, Marianna Lauricella, Daniela Carlisi, Anna De Blasio, Michela Giuliano
Summary: The article discusses the roles of Nrf2 in both cancer and COVID-19, highlighting its protective function in normal cells but potential overstimulation in tumor cells. Nrf2 exhibits different mechanisms of action in cancer and COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Mengyao Wang, Feng Zhang, Jie Zhou, Ke Gong, Shasha Chen, Xinran Zhu, Mengxue Zhang, Yajun Duan, Chenzhong Liao, Jihong Han, Zequn Yin
Summary: Licorice is a versatile herbal medicine and food, and glabridin (Gla) extracted from licorice root has various health benefits. The research discovered the positive effect of Gla in treating alcoholic liver disease (ALD) in mice and liver cells. Gla alleviated liver injury caused by ethanol, reduced inflammation and oxidative stress, and restored antioxidant enzyme activity. Gla also regulated specific molecular pathways involved in ALD. Overall, Gla shows promise as a potential health product or drug for ALD.
Article
Orthopedics
Peng Zhang, Yesheng Jin, Wei Xia, Xiaotong Wang, Zhiqiang Zhou
Summary: This study found that the active ingredient PHI from Forsythiae Fructus can alleviate IL-1 beta-induced inflammation cytokines and ECM degradation by activating Nrf2 and inhibiting the NF-kappa B pathway. This provides a biological rationale for the use of PHI as a potential candidate for OA treatment.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Immunology
Qiang Li, Chenxu Ge, Jun Tan, Yan Sun, Qin Kuang, Xianling Dai, Shaoyu Zhong, Chao Yi, Lin-Feng Hu, De-Shuai Lou, Minxuan Xu
Summary: The study showed that Jug could alleviate obesity-induced renal injury by suppressing the nuclear translocation of NF-kappa B and HDAC3, thus reducing inflammation and lipid accumulation, ultimately improving kidney function.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yingjie Zhu, Chunyan Wang, Jingjing Luo, Shucheng Hua, Dan Li, Liping Peng, Hongmei Liu, Lei Song
Summary: Zingerone treatment alleviated oxidative stress and inflammation in asthma models by upregulating the AMPK/Nrf2/HO-1 signaling pathway.
Article
Nutrition & Dietetics
Yongfeng Zhang, Jie Hao, Zijian Liu, Zhige Li, Lirong Teng, Di Wang
Summary: This study investigated the regulatory effects of Inonotus hispidus (IH) on lipid metabolism in mice fed a high-fat diet (HFD). The results showed that IH could reverse the pathological state of the liver and fat, decrease the levels of LDL-C, TC, TG, and LEP, and increase the level of HDL-C in serum. Additionally, IH improved liver damage and modulated the gut microbiota. IH regulated the Nrf2/NF-κB signaling pathway and oxidative stress. These findings provide experimental evidence for the potential use of IH in obesity treatment.
Article
Veterinary Sciences
Mingjiang Liu, Chi Zhang, Xiaolong Xu, Xin Zhao, Ziyi Han, Dandan Liu, Ruonan Bo, Jingui Li, Zongping Liu
Summary: The study revealed that ferulic acid (FA) has a protective effect on lipopolysaccharide (LPS)-induced bovine mammary epithelial cell (BMEC) apoptosis by restoring redox balance, inhibiting mitochondrial dysfunction, reducing oxidative stress, decreasing NF-kappa B activation, enhancing Nrf2 activation, and maintaining cell viability. Treatment with FA alone showed induction of Nrf2 activation before inhibition of NF-kappa B activation, suggesting that FA may prevent BMEC apoptosis by reversing the dominant relationship between NF-kappa B and Nrf2.
VETERINARY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Shujuan Li, Yan Li, Li Hou, Li Tang, Fang Gao
Summary: Forsythoside B hampers IL-1 beta-elicited rat chondrocyte apoptosis, oxidative stress, and facilitates proliferation. It suppresses the profiles of inflammatory factors and NOD-like receptor family pyrin domain containing 3 inflammasomes, as well as Kelch-like epichlorohydrin-associated protein-1 (Keap1) and nuclear factor-kappa B (NF-kappa B) phosphorylation, while promotes nuclear factor E2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) levels. Furthermore, Forsythoside B mitigates cartilage damage and degeneration.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Ivan Cruz-Chamorro, Guillermo Santos-Sanchez, Carlotta Bollati, Martina Bartolomei, Jianqiang Li, Anna Arnoldi, Carmen Lammi
Summary: In this study, the anti-inflammatory and immunomodulatory properties of H2 and H3 were molecularly characterized, and it was found that these peptides can reduce inflammatory responses and oxidative stress markers by modulating the NF-kappa B and iNOS pathways, suggesting their potential therapeutic value.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Cell Biology
Gong-Rak Lee, Hye In Lee, Narae Kim, Jiae Lee, Minjeong Kwon, Ye Hee Kang, Hyeong Ju Song, Chang-Yeol Yeo, Woojin Jeong
Summary: This study investigated the role of LC8 in nonalcoholic steatohepatitis (NASH) and explored its potential mechanism. The results showed that LC8 can alleviate NASH induced by an MCD diet by inhibiting NF-kappa B and reducing oxidative stress. Therefore, enhancing intracellular LC8 could be a potential therapeutic strategy for NASH.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Haseeb Ahsan, Salman Ul Islam, Muhammad Bilal Ahmed, Young Sup Lee
Summary: Cancer is a complex disease that can be prevented or suppressed through chemoprevention. Targeting molecules such as Nrf2, STAT3, and Src, which are involved in various pathways of cancer, can reduce oxidative stress and inflammation and stop cancer initiation and progression.
Article
Chemistry, Applied
Shanshan Teng, Yongfeng Zhang, Xinghui Jin, Yanfeng Zhu, Lanzhou Li, Xiaowei Huang, Di Wang, Zhe Lin
Summary: The water-soluble Morchella esculenta polysaccharide 2 (MEP2) was purified and isolated from an aqueous extract of the Morchella esculenta fruiting bodies. MEP2, with a molecular weight of 959 kDa, has a glucan backbone and substitutions at the H-6 position. The study also revealed that MEP2 has hepatoprotective activity and regulates hepatic cytokines through the Usp10/NF-kappa B/Nrf2 signaling pathway.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Lin-Feng Hu, Jing Feng, Xianling Dai, Yan Sun, Mingxin Xiong, Lili Lai, Shaoyu Zhong, Chao Yi, Geng Chen, Huanhuan Li, Qiufeng Yang, Qin Kuang, Tingting Long, Jianxia Zhan, Tingting Tang, Chenxu Ge, Jun Tan, Minxuan Xu
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2020)
Article
Endocrinology & Metabolism
Minxuan Xu, Chenxu Ge, Yuting Qin, Deshuai Lou, Qiang Li, Jing Feng, Yekuan Wu, Linfeng Hu, Bochu Wang, Jun Tan
MOLECULAR METABOLISM
(2020)
Article
Gastroenterology & Hepatology
Minxuan Xu, Chenxu Ge, Liancai Zhu, Yuting Qin, Chengjiang Du, Deshuai Lou, Qiang Li, Linfeng Hu, Yan Sun, Xianling Dai, Mingxin Xiong, Tingting Long, Jianxia Zhan, Qin Kuang, Huanhuan Li, Qiufeng Yang, Ping Huang, Xuepeng Teng, Jing Feng, Yekuan Wu, Wei Dong, Bochu Wang, Jun Tan
Summary: The study demonstrates that iRhom2 plays a crucial role in promoting hepatic steatosis and insulin resistance. Mice with iRhom2 deficiency show less severe hepatic steatosis and insulin resistance, indicating iRhom2 as a potential therapeutic target for NAFLD-related complications.
Article
Engineering, Environmental
Xu Min-Xuan, Dai Xian-Ling, Kuang Qin, Zhu Lian-Cai, Hu Lin-Feng, Lou De-Shuai, Li Qiang, Feng Jing, Wu Ye-Kuan, Ge Chen-Xu, Wang Bo-Chu, Tan Jun
JOURNAL OF HAZARDOUS MATERIALS
(2020)
Article
Cell Biology
Qiang Li, Qifei Xu, Jun Tan, Linfeng Hu, Chenxu Ge, Minxuan Xu
Summary: Carminic acid (CA) significantly reduced inflammation and oxidative stress in the kidneys by regulating NF- κ B and Nrf-2 signaling pathways, alleviating the progression of chronic kidney injury induced by excessive fructose (Fru).
Article
Immunology
Qiang Li, Chenxu Ge, Jun Tan, Yan Sun, Qin Kuang, Xianling Dai, Shaoyu Zhong, Chao Yi, Lin-Feng Hu, De-Shuai Lou, Minxuan Xu
Summary: The study showed that Jug could alleviate obesity-induced renal injury by suppressing the nuclear translocation of NF-kappa B and HDAC3, thus reducing inflammation and lipid accumulation, ultimately improving kidney function.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Ling Li, Bo Fang, Yinglei Zhang, Liuqing Yan, Yuxin He, Linfeng Hu, Qifei Xu, Qiang Li, Xianling Dai, Qin Kuang, Minxuan Xu, Jun Tan, Chenxu Ge
Summary: Carminic acid (CA) can effectively alleviate nonalcoholic fatty liver disease (NAFLD) induced by excessive fructose consumption, mainly through suppressing inflammatory response and oxidative stress, as well as improving dyslipidemia.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Gastroenterology & Hepatology
Min-Xuan Xu, Jun Tan, Chen-Xu Ge, Wei Dong, Li-Ting Zhang, Lian-Cai Zhu, Jun-Jie Zhao, Long-Yan Wang, Jin Liu, Hao Wei, Yan Sun, Xian-Ling Dai, Qin Kuang, Yan-Liang Li, Han Li, Jun-Yan Liu, Lei Zou, Ran-Ran Liang, Chu-Feng Zhang, Juan Xu, Bo-Chu Wang
Summary: TRIM31, a member of the E3 ubiquitin ligases family, has been identified as an efficient endogenous inhibitor of MAP3K7, and may serve as a promising therapeutic target for NASH treatment and associated metabolic disorders.
Article
Food Science & Technology
Xianling Dai, Qin Kuang, Yan Sun, Minxuan Xu, Liancai Zhu, Chenxu Ge, Jun Tan, Bochu Wang
Summary: The study revealed that Fisetin can efficiently attenuate NAFLD by restraining ROS generation and alleviating mitochondrial impairment.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Multidisciplinary Sciences
Minxuan Xu, Jun Tan, Wei Dong, Benkui Zou, Xuepeng Teng, Liancai Zhu, Chenxu Ge, Xianling Dai, Qin Kuang, Shaoyu Zhong, Lili Lai, Chao Yi, Tingting Tang, Junjie Zhao, Longyan Wang, Jin Liu, Hao Wei, Yan Sun, Qiufeng Yang, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Mingxin Xiong, Jing Feng, Chufeng Zhang, Bochu Wang
Summary: This study reveals that Trim31 acts as an endogenous inhibitor of Rhbdf2 in mice, mitigating the development of NASH and potentially serving as a therapeutic target for treating NAFLD/NASH and associated metabolic disorders.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Chenxu Ge, Jun Tan, Deshuai Lou, Liancai Zhu, Zixuan Zhong, Xianling Dai, Yan Sun, Qin Kuang, Junjie Zhao, Longyan Wang, Jin Liu, Bochu Wang, Minxuan Xu
Summary: In this study, Mul administration was found to significantly ameliorate liver injury and dysfunction induced by CCl4 in mice. The underlying mechanisms involve the suppression of TGF-beta 1/SMAD2/3 signaling pathway and NF-kappa B signaling, as well as the activation of TRIM31 and Nrf2 pathways. These findings provide a novel therapeutic strategy for hepatic fibrosis treatment.
Article
Multidisciplinary Sciences
Chenxu Ge, Jun Tan, Xianling Dai, Qin Kuang, Shaoyu Zhong, Lili Lai, Chao Yi, Yan Sun, Jing Luo, Chufeng Zhang, Liancai Zhu, Bochu Wang, Minxuan Xu
Summary: This study reveals that the decreased expression of DUSP22 in fatty liver exacerbates NASH and NAFLD progression, leading to HCC. In contrast, over-expression of DUSP22 inhibits NASH and HCC development. The study also demonstrates the importance of the interaction between DUSP22 and FAK in improving NASH.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Minxuan Xu, Jun Tan, Xin Liu, Li Han, Chenxu Ge, Yujie Zhang, Fufang Luo, Zhongqin Wang, Xiaoqin Xue, Liangyin Xiong, Xin Wang, Qinqin Zhang, Xiaoxin Wang, Qin Tian, Shuguang Zhang, Qingkun Meng, Xianling Dai, Qin Kuang, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Chunxiao Chang, Bochu Wang, Jie Chai, Shengbin Shi, Lianyi Han
Summary: The E3 ligase TRIM26 is identified as a key suppressor in the development of NASH by inhibiting CCAAT/enhancer binding protein delta (C/EBP δ). This finding has important implications for the treatment and understanding of NASH.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Minxuan Xu, Jun Tan, Liancai Zhu, Chenxu Ge, Yi Zhang, Fufeng Gao, Xianling Dai, Qin Kuang, Jie Chai, Benkui Zou, Bochu Wang
Summary: Underestimation of the complexity of NASH pathogenesis hinders the development of new drugs and targeted therapies. This study revealed that IRHOM2 is post-translationally S-palmitoylated at C476, which facilitates its translocation and stabilization. ZDHHC3 was identified as the key acetyltransferase required for IRHOM2 palmitoylation, and its increased association with IRHOM2 promotes palmitoylation and prevents ubiquitination-mediated degradation.