An amino acid-defined diet impairs tumour growth in mice by promoting endoplasmic reticulum stress and mTOR inhibition

Excess Exogenous Pyruvate Inhibits Lactate Dehydrogenase Activity in Live Cells in a MCT1-Dependent Manner

(2021) Yi Rao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Special Amino-Acid Formula Tailored to Boosting Cell Respiration Prevents Mitochondrial Dysfunction and Oxidative Stress Caused by Doxorubicin in Mouse Cardiomyocytes

(2020) Laura Tedesco et al.   Nutrients

Physiological Role of Glutamate Dehydrogenase in Cancer Cells

(2020) Rafael Moreno-Sánchez et al.   Frontiers in Oncology

Manipulation of Dietary Amino Acids Prevents and Reverses Obesity in Mice Through Multiple Mechanisms That Modulate Energy Homeostasis

(2020) Chiara Ruocco et al.   DIABETES

Pathophysiological role of metabolic flexibility on metabolic health

(2020) Jose E. Galgani et al.   Obesity Reviews

Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression

(2019) Russell E. Ericksen et al.   Cell Metabolism

GC–MS metabolic profiling reveals fructose-2,6-bisphosphate regulates branched chain amino acid metabolism in the heart during fasting

(2019) Albert Batushansky et al.   Metabolomics

BCAA Catabolic Defect Alters Glucose Metabolism in Lean Mice

(2019) Ji Wang et al.   Frontiers in Physiology

From mitochondria to healthy aging: The role of branched-chain amino acids treatment: MATeR a randomized study

(2019) Ilaria Buondonno et al.   CLINICAL NUTRITION

Nutrient regulation of mTORC1 at a glance

(2019) Kendall J. Condon et al.   JOURNAL OF CELL SCIENCE

ATF4-Mediated Upregulation of REDD1 and Sestrin2 Suppresses mTORC1 Activity during Prolonged Leucine Deprivation

(2019) Dandan Xu et al.   JOURNAL OF NUTRITION

A specific amino acid formula prevents alcoholic liver disease in rodents

(2018) Laura Tedesco et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect

(2018) Linchong Sun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge

(2018) Sho Koyasu et al.   CANCER SCIENCE

Inhibition of Glycolysis and Glutaminolysis: An Emerging Drug Discovery Approach to Combat Cancer

(2018) Nicholas S. Akins et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Glucose promotes cell growth by suppressing branched-chain amino acid degradation

(2018) Dan Shao et al.   Nature Communications

Supplementation with a selective amino acid formula ameliorates muscular dystrophy in mdx mice

(2018) Stefania Banfi et al.   Scientific Reports

Mice deficient in the mitochondrial branched-chain aminotransferase (BCATm) respond with delayed tumour growth to a challenge with EL-4 lymphoma

(2018) Elitsa A. Ananieva et al.   BRITISH JOURNAL OF CANCER

Drug-induced amino acid deprivation as strategy for cancer therapy

(2017) Marcus Kwong Lam Fung et al.   Journal of Hematology & Oncology

Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass

(2017) Jessica B. Spinelli et al.   SCIENCE

Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers

(2017) Jeff Charles Kremer et al.   Cell Reports

Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells

(2017) Elise Saunier et al.   Scientific Reports

A Peculiar Formula of Essential Amino Acids Prevents Rosuvastatin Myopathy in Mice

(2016) Giuseppe D'Antona et al.   ANTIOXIDANTS & REDOX SIGNALING

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells

(2016) Aaron M. Hosios et al.   DEVELOPMENTAL CELL

The Enigma of Rapamycin Dosage

(2016) S. Mukhopadhyay et al.   MOLECULAR CANCER THERAPEUTICS

Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells

(2016) Oliver D.K. Maddocks et al.   MOLECULAR CELL

Glycolysis Inhibitors for Anticancer Therapy: A Review of Recent Patents

(2016) Huaming Sheng et al.   Recent Patents on Anti-Cancer Drug Discovery

Pyruvate and Metabolic Flexibility: Illuminating a Path Toward Selective Cancer Therapies

(2016) Kristofor A. Olson et al.   TRENDS IN BIOCHEMICAL SCIENCES

Leucine deprivation inhibits proliferation and induces apoptosis of human breast cancer cells via fatty acid synthase

(2016) Fei Xiao et al.   Oncotarget

Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells

(2016) Bradley Smith et al.   Cell Reports

Serine one-carbon catabolism with formate overflow

(2016) J. Meiser et al.   Science Advances

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis

(2015) Yan Xiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Efficacy and safety of oral branched-chain amino acid supplementation in patients undergoing interventions for hepatocellular carcinoma: a meta-analysis

(2015) Ling Chen et al.   Nutrition Journal

Dietary protein restriction inhibits tumor growth in human xenograft models

(2015) Luigi Fontana et al.   Oncotarget

Serine Deprivation Enhances Antineoplastic Activity of Biguanides

(2014) S.-P. Gravel et al.   CANCER RESEARCH

Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase

(2014) Shih-Chia Tso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development

(2014) Jared R Mayers et al.   NATURE MEDICINE

Branched-chain amino acids in metabolic signalling and insulin resistance

(2014) Christopher J. Lynch et al.   Nature Reviews Endocrinology

Aspartate aminotransferase: An old dog teaches new tricks

(2013) Michael D. Toney   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

mTOR kinase inhibitors as potential cancer therapeutic drugs

(2013) Shi-Yong Sun   CANCER LETTERS

Estimation of rat mammary tumor volume using caliper and ultrasonography measurements

(2013) Ana Faustino-Rocha et al.   LAB ANIMAL

BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1

(2013) Martje Tönjes et al.   NATURE MEDICINE

The Transcription Factor Network Associated With the Amino Acid Response in Mammalian Cells

(2012) Michael S. Kilberg et al.   Advances in Nutrition

High-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1

(2011) Paige Yellen et al.   CELL CYCLE

Oral Branched-Chain Amino Acid Granules Reduce the Incidence of Hepatocellular Carcinoma and Improve Event-Free Survival in Patients with Liver Cirrhosis

(2011) Sosuke Hayaishi et al.   DIGESTIVE DISEASES

Increases in mitochondrial biogenesis impair carcinogenesis at multiple levels

(2011) Xiao Wang et al.   Molecular Oncology

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

(2011) Jason W Locasale et al.   NATURE GENETICS

Galactose Enhances Oxidative Metabolism and Reveals Mitochondrial Dysfunction in Human Primary Muscle Cells

(2011) Céline Aguer et al.   PLoS One

Branched-Chain Amino Acid Supplementation Promotes Survival and Supports Cardiac and Skeletal Muscle Mitochondrial Biogenesis in Middle-Aged Mice

(2010) Giuseppe D'Antona et al.   Cell Metabolism

Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

(2010) J. H. Lee et al.   SCIENCE

Amino acids: metabolism, functions, and nutrition

(2009) Guoyao Wu   AMINO ACIDS

Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells

(2009) Gang Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

Amino Acids and Mitochondrial Biogenesis

(2008) Enzo Nisoli et al.   AMERICAN JOURNAL OF CARDIOLOGY