A Special Amino-Acid Formula Tailored to Boosting Cell Respiration Prevents Mitochondrial Dysfunction and Oxidative Stress Caused by Doxorubicin in Mouse Cardiomyocytes

Ursolic acid prevents doxorubicin-induced cardiac toxicity in mice through eNOS activation and inhibition of eNOS uncoupling

(2019) Haiman Mu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration

(2019) Chowdhury S. Abdullah et al.   Scientific Reports

Pre-Operative vs. Peri-Operative Nutrition Supplementation in Hepatic Resection for Cancer: A Systematic Review

(2019) Bartholomew P. McKay et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Cardioprotective roles of Sestrin1 and Sestrin2 against doxorubicin cardiotoxicity

(2019) Ruiting Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure

(2019) Golam M. Uddin et al.   Cardiovascular Diabetology

Exercise stimulates beneficial adaptations to diminish doxorubicin-induced cellular toxicity

(2019) Ashley J. Smuder   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

A specific amino acid formula prevents alcoholic liver disease in rodents

(2018) Laura Tedesco et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

New Insights Into the Role of mTOR Signaling in the Cardiovascular System

(2018) Sebastiano Sciarretta et al.   CIRCULATION RESEARCH

Protective effect of KLF15 on vascular endothelial dysfunction induced by TNF‑α

(2018) Bing Liu et al.   Molecular Medicine Reports

Krüppel-like factor 15: Regulator of BCAA metabolism and circadian protein rhythmicity

(2018) Liyan Fan et al.   PHARMACOLOGICAL RESEARCH

Kruppel-like factor 15 is required for the cardiac adaptive response to fasting

(2018) Keiki Sugi et al.   PLoS One

Opposite Carcinogenic Effects of Circadian Clock Gene BMAL1

(2018) Tuba Korkmaz et al.   Scientific Reports

Folic acid reduces doxorubicin-induced cardiomyopathy by modulating endothelial nitric oxide synthase

(2017) Yanti Octavia et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Taiwanese and Japanese yam ( Dioscorea spp.) extracts attenuate doxorubicin-induced cardiotoxicity in mice

(2017) Chih-Tai Chen et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Modeling Human Myocardium Exposure to Doxorubicin Defines the Risk of Heart Failure from Low-Dose Doxorubicin

(2017) Emanuela Salvatorelli et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Effects of doxorubicin on cardiac muscle subsarcolemmal and intermyofibrillar mitochondria

(2017) Andreas N. Kavazis et al.   MITOCHONDRION

Branched-Chain Amino Acid Negatively Regulates KLF15 Expression via PI3K-AKT Pathway

(2017) Yunxia Liu et al.   Frontiers in Physiology

A Peculiar Formula of Essential Amino Acids Prevents Rosuvastatin Myopathy in Mice

(2016) Giuseppe D'Antona et al.   ANTIOXIDANTS & REDOX SIGNALING

Catabolic Defect of Branched-Chain Amino Acids Promotes Heart FailureCLINICAL PERSPECTIVE

(2016) Haipeng Sun et al.   CIRCULATION

Human induced pluripotent stem cell–derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity

(2016) Paul W Burridge et al.   NATURE MEDICINE

mTORC1 is involved in the regulation of branched-chain amino acid catabolism in mouse heart

(2016) Hongmin Zhen et al.   FEBS Open Bio

Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective

(2016) Alessandra Valerio et al.   Aging-US

Ginkgolide B Exerts Cardioprotective Properties against Doxorubicin-Induced Cardiotoxicity by Regulating Reactive Oxygen Species, Akt and Calcium Signaling Pathways In Vitro and In Vivo

(2016) Junqing Gao et al.   PLoS One

Efficacy and safety of oral branched-chain amino acid supplementation in patients undergoing interventions for hepatocellular carcinoma: a meta-analysis

(2015) Ling Chen et al.   Nutrition Journal

Polymorphisms of ABCC5 and NOS3 genes influence doxorubicin cardiotoxicity in survivors of childhood acute lymphoblastic leukemia

(2015) M Krajinovic et al.   PHARMACOGENOMICS JOURNAL

Exercise training boosts eNOS-dependent mitochondrial biogenesis in mouse heart: role in adaptation of glucose metabolism

(2014) Roberto Vettor et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Clinical significance of early interventional therapy of branched-chain amino acid granules in patients with hepatocellular carcinoma: Propensity score matching analysis

(2014) HIROKI NISHIKAWA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Congenital Absence of Nitric Oxide Synthase 3 Potentiates Cardiac Dysfunction and Reduces Survival in Doxorubicin- and Trastuzumab-Mediated Cardiomyopathy

(2013) Matthew Zeglinski et al.   CANADIAN JOURNAL OF CARDIOLOGY

KLF15 Is a Molecular Link between Endoplasmic Reticulum Stress and Insulin Resistance

(2013) Dae Young Jung et al.   PLoS One

Klf15 Orchestrates Circadian Nitrogen Homeostasis

(2012) Darwin Jeyaraj et al.   Cell Metabolism

Krueppel-like factor 15 regulates Wnt/β-catenin transcription and controls cardiac progenitor cell fate in the postnatal heart

(2012) Claudia Noack et al.   EMBO Molecular Medicine

Tissue-specific and Nutrient Regulation of the Branched-chain α-Keto Acid Dehydrogenase Phosphatase, Protein Phosphatase 2Cm (PP2Cm)

(2012) Meiyi Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

(2012) Sui Zhang et al.   NATURE MEDICINE

Arginine enhances embryo implantation in rats through PI3K/PKB/mTOR/NO signaling pathway during early pregnancy

(2012) Xiangfang Zeng et al.   REPRODUCTION

Branched-Chain Amino Acid Supplementation Promotes Survival and Supports Cardiac and Skeletal Muscle Mitochondrial Biogenesis in Middle-Aged Mice

(2010) Giuseppe D'Antona et al.   Cell Metabolism

Amino Acids Activate Mammalian Target of Rapamycin Complex 2 (mTORC2) via PI3K/Akt Signaling

(2010) Irantzu Tato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of the cannabinoid CB1 antagonist rimonabant on hepatic mitochondrial function in rats fed a high-fat diet

(2009) Mélissa Flamment et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action

(2009) Ghada A. Soliman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leptin-dependent STAT3 phosphorylation in postnatal mouse hypothalamus

(2008) Andrea Frontini et al.   BRAIN RESEARCH

In human endothelial cells rapamycin causes mTORC2 inhibition and impairs cell viability and function

(2008) Amelia Barilli et al.   CARDIOVASCULAR RESEARCH

Acute Doxorubicin Cardiotoxicity Is Associated With p53-Induced Inhibition of the Mammalian Target of Rapamycin Pathway

(2008) Wuqiang Zhu et al.   CIRCULATION

Cannabinoid Type 1 Receptor Blockade Promotes Mitochondrial Biogenesis Through Endothelial Nitric Oxide Synthase Expression in White Adipocytes

(2008) L. Tedesco et al.   DIABETES

The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts

(2008) Baiqiu Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY