Tissue Resident Foxp3+ Regulatory T Cells: Sentinels and Saboteurs in Health and Disease

Systemic Sclerosis: From Pathophysiology to Novel Therapeutic Approaches

(2022) Devis Benfaremo et al.   Biomedicines

P2X7 Receptor Antagonist Reduces Fibrosis and Inflammation in a Mouse Model of Alpha-Sarcoglycan Muscular Dystrophy

(2022) Lizzia Raffaghello et al.   Pharmaceuticals

Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19

(2021) Peter A. Szabo et al.   IMMUNITY

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

(2021) McLane J. Watson et al.   NATURE

Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells

(2021) Rebekka Duhen et al.   Nature Communications

Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy

(2021) Helena Van Damme et al.   Journal for ImmunoTherapy of Cancer

Fc-optimized Anti-CCR8 Antibody Depletes Regulatory T Cells in Human Tumor Models

(2021) Joseph R Campbell et al.   CANCER RESEARCH

MondoA-TXNIP axis maintains regulatory T cell identity and function in colorectal cancer microenvironment

(2021) Ying Lu et al.   GASTROENTEROLOGY

PPARγ marks splenic precursors of multiple nonlymphoid-tissue Treg compartments

(2021) Chaoran Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-term results of sirolimus treatment in lymphangioleiomyomatosis: a single referral centre experience

(2021) Eva Revilla-López et al.   Scientific Reports

Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity

(2021) Chaoran Li et al.   Cell Metabolism

Environmental enteric dysfunction induces regulatory T cells that inhibit local CD4+ T cell responses and impair oral vaccine efficacy

(2021) Amrita Bhattacharjee et al.   IMMUNITY

Influenza virus infection selectively triggers the accumulation and persistence of more potent Helios‐expressing Foxp3 + regulatory T cells in the lungs

(2021) Chunni Lu et al.   IMMUNOLOGY AND CELL BIOLOGY

RORγt Promotes Foxp3 Expression by Antagonizing the Effector Program in Colonic Regulatory T Cells

(2021) Suniti Bhaumik et al.   JOURNAL OF IMMUNOLOGY

Obesity accelerates hair thinning by stem cell-centric converging mechanisms

(2021) Hironobu Morinaga et al.   NATURE

Insulin signaling establishes a developmental trajectory of adipose regulatory T cells

(2021) Yangyang Li et al.   NATURE IMMUNOLOGY

TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer

(2021) Abu Osman et al.   NATURE IMMUNOLOGY

Profound Treg perturbations correlate with COVID-19 severity

(2021) Silvia Galván-Peña et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peripheral and lung resident memory T cell responses against SARS-CoV-2

(2021) Judith Grau-Expósito et al.   Nature Communications

The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes

(2021) Shen Dong et al.   JCI Insight

Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes

(2021) Maximilien Evrard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mucosal tissue regulatory T cells are integral in balancing immunity and tolerance at portals of antigen entry

(2021) Brianna R. Traxinger et al.   Mucosal Immunology

Donor‐specific chimeric antigen receptor Tregs limit rejection in naive but not sensitized allograft recipients

(2020) Antoine Sicard et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Regulatory T Cells and Human Disease

(2020) Shimon Sakaguchi et al.   Annual Review of Immunology

Sex-specific adipose tissue imprinting of regulatory T cells

(2020) Ajithkumar Vasanthakumar et al.   NATURE

Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy

(2020) Meenu Sharma et al.   Nature Communications

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

(2020) Chuan Qin et al.   CLINICAL INFECTIOUS DISEASES

Tissue Tregs

(2020) Prudence PokWai Lui et al.   IMMUNOLOGY

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

The obesity-induced adipokine sST2 exacerbates adipose Treg and ILC2 depletion and promotes insulin resistance

(2020) Xu-Yun Zhao et al.   Science Advances

Low-dose IL-2 in children with recently diagnosed type 1 diabetes: a Phase I/II randomised, double-blind, placebo-controlled, dose-finding study

(2020) Michelle Rosenzwajg et al.   DIABETOLOGIA

Regulatory T cells promote adipocyte beiging in subcutaneous adipose tissue

(2020) Wenqian Fang et al.   FASEB JOURNAL

Proenkephalin+ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function

(2020) Hiroaki Shime et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The laboratory tests and host immunity of COVID-19 patients with different severity of illness

(2020) Feng Wang et al.   JCI Insight

IL‐33 drives the production of mouse regulatory T cells with enhanced in vivo suppressive activity in skin transplantation

(2020) Kento Kawai et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Regulatory T cells: Master thieves of the immune system

(2020) Billur Akkaya et al.   CELLULAR IMMUNOLOGY

Safety and Clinical Activity of MEDI1873, a Novel GITR Agonist, in Advanced Solid Tumors

(2020) Ani S. Balmanoukian et al.   CLINICAL CANCER RESEARCH

Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity

(2020) Jacob A. Turner et al.   IMMUNITY

Treg Enhancing Therapies to Treat Autoimmune Diseases

(2020) Peter J. Eggenhuizen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Th17 and Treg cells function in SARS‐CoV2 patients compared with healthy controls

(2020) Armin Sadeghi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Many Functions of Foxp3+ Regulatory T Cells in the Intestine

(2020) Catalina Cosovanu et al.   Frontiers in Immunology

Building a CAR-Treg: Going from the basic to the luxury model

(2020) Isaac Rosado-Sánchez et al.   CELLULAR IMMUNOLOGY

Oleic acid restores suppressive defects in tissue-resident FOXP3 Tregs from patients with multiple sclerosis

(2020) Saige L. Pompura et al.   JOURNAL OF CLINICAL INVESTIGATION

Talpid3-Mediated Centrosome Integrity Restrains Neural Progenitor Delamination to Sustain Neurogenesis by Stabilizing Adherens Junctions

(2020) Jingjing Wang et al.   Cell Reports

Tregs facilitate obesity and insulin resistance via a Blimp-1-IL-10 axis

(2020) Lisa Y. Beppu et al.   JCI Insight

Regulatory T cells in cancer immunosuppression — implications for anticancer therapy

(2019) Yosuke Togashi et al.   Nature Reviews Clinical Oncology

A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells

(2019) Frédéric Van Gool et al.   IMMUNITY

The IL-33/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancer

(2019) Eva Pastille et al.   Mucosal Immunology

Functional Phenotypic Diversity of Regulatory T Cells Remaining in Inflamed Skin

(2019) Ryoyo Ikebuchi et al.   Frontiers in Immunology

Efficacy and safety of low-dose IL-2 in the treatment of systemic lupus erythematosus: a randomised, double-blind, placebo-controlled trial

(2019) Jing He et al.   ANNALS OF THE RHEUMATIC DISEASES

Increased infiltration of CCR4‐positive regulatory T cells in prostate cancer tissue is associated with a poor prognosis

(2019) Masahito Watanabe et al.   PROSTATE

Regulatory T cells in skin are uniquely poised to suppress profibrotic immune responses

(2019) Lokesh A. Kalekar et al.   Science Immunology

Developmental and cellular age direct conversion of CD4+ T cells into RORγ+ or Helios+ colon Treg cells

(2019) Alvin Pratama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD103hi Treg cells constrain lung fibrosis induced by CD103lo tissue-resident pathogenic CD4 T cells

(2019) Tomomi Ichikawa et al.   NATURE IMMUNOLOGY

Short-term cold exposure supports human Treg induction in vivo

(2019) Maike Becker et al.   Molecular Metabolism

Safety, Tolerability, and Potential Clinical Activity of a Glucocorticoid-Induced TNF Receptor–Related Protein Agonist Alone or in Combination With Nivolumab for Patients With Advanced Solid Tumors

(2019) Kimberley M. Heinhuis et al.   JAMA Oncology

T cell receptor specificity drives accumulation of a reparative population of regulatory T cells within acutely injured skeletal muscle

(2019) Jun Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Pathways Involved in Regulatory T Cell Functionality

(2019) Rosalie W. M. Kempkes et al.   Frontiers in Immunology

Metabolic Control of Treg Cell Stability, Plasticity, and Tissue-Specific Heterogeneity

(2019) Hao Shi et al.   Frontiers in Immunology

TCR Transgenic Mice Reveal Stepwise, Multi-site Acquisition of the Distinctive Fat-Treg Phenotype

(2018) Chaoran Li et al.   CELL

Tregcells limit IFN-γ production to control macrophage accrual and phenotype during skeletal muscle regeneration

(2018) Marisella Panduro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction

(2018) Serena Zacchigna et al.   Nature Communications

Immunological and clinical effects of low-dose interleukin-2 across 11 autoimmune diseases in a single, open clinical trial

(2018) Michelle Rosenzwajg et al.   ANNALS OF THE RHEUMATIC DISEASES

Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery

(2018) Minako Ito et al.   NATURE

Differential gene expression in human tissue resident regulatory T cells from lung, colon, and blood

(2018) Magdalena Niedzielska et al.   Oncotarget

Regulatory T Cells Restrain Pathogenic T Helper Cells during Skin Inflammation

(2018) Tom Hartwig et al.   Cell Reports

Regulatory T cells promote myelin regeneration in the central nervous system

(2017) Yvonne Dombrowski et al.   NATURE NEUROSCIENCE

Tissue-resident Lymphocytes in Solid Organ Transplantation

(2017) Amy C. Prosser et al.   TRANSPLANTATION

Effector and Regulatory T Cells Roll at High Shear Stress by Inducible Tether and Sling Formation

(2017) Michael Abadier et al.   Cell Reports

CD4 + CD25 hi Foxp3 + Cells Exacerbate Bleomycin-Induced Pulmonary Fibrosis

(2016) Shirin Z. Birjandi et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulatory T Cells in Idiopathic Pulmonary Fibrosis

(2016) Meagan W. Moore et al.   AMERICAN JOURNAL OF PATHOLOGY

Hepatic Infiltrates in Operational Tolerant Patients After Liver Transplantation Show Enrichment of Regulatory T Cells Before Proinflammatory Genes Are Downregulated

(2016) R. Taubert et al.   AMERICAN JOURNAL OF TRANSPLANTATION

From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation

(2016) Rosa Bacchetta et al.   Annals of the New York Academy of Sciences

Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells

(2016) Marco De Simone et al.   IMMUNITY

Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer

(2016) George Plitas et al.   IMMUNITY

Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells

(2016) Wilson Kuswanto et al.   IMMUNITY

Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing

(2016) Audrey Nosbaum et al.   JOURNAL OF IMMUNOLOGY

Induced Regulatory T Cells: Their Development, Stability, and Applications

(2016) Mitsuhiro Kanamori et al.   TRENDS IN IMMUNOLOGY

A rare subset of skin-tropic regulatory T cells expressing Il10/Gzmb inhibits the cutaneous immune response

(2016) Ryoyo Ikebuchi et al.   Scientific Reports

Enhancement of Muscle T Regulatory Cells and Improvement of Muscular Dystrophic Process in mdx Mice by Blockade of Extracellular ATP/P2X Axis

(2015) Elisabetta Gazzerro et al.   AMERICAN JOURNAL OF PATHOLOGY

A Distinct Function of Regulatory T Cells in Tissue Protection

(2015) Nicholas Arpaia et al.   CELL

Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice

(2015) Dmitriy Kolodin et al.   Cell Metabolism

Complete Remissions of Adult T-cell Leukemia with Anti-CD25 Recombinant Immunotoxin LMB-2 and Chemotherapy to Block Immunogenicity

(2015) R. J. Kreitman et al.   CLINICAL CANCER RESEARCH

Phase Ia Study of FoxP3+ CD4 Treg Depletion by Infusion of a Humanized Anti-CCR4 Antibody, KW-0761, in Cancer Patients

(2015) K. Kurose et al.   CLINICAL CANCER RESEARCH

Development of thymic Foxp3+ regulatory T cells: TGF-β matters

(2015) WanJun Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes

(2015) Tiffany C. Scharschmidt et al.   IMMUNITY

Regulatory T cells produce profibrotic cytokines in the skin of patients with systemic sclerosis

(2015) Katherine G. MacDonald et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients

(2015) Michelle Rosenzwajg et al.   JOURNAL OF AUTOIMMUNITY

Regulatory T Cell Induction and Retention in the Lungs Drives Suppression of Detrimental Type 2 Th Cells During Pulmonary Cryptococcal Infection

(2015) Darin L. Wiesner et al.   JOURNAL OF IMMUNOLOGY

IL-33 Reverses an Obesity-Induced Deficit in Visceral Adipose Tissue ST2+T Regulatory Cells and Ameliorates Adipose Tissue Inflammation and Insulin Resistance

(2015) Jonathan M. Han et al.   JOURNAL OF IMMUNOLOGY

Diphtheria-toxin based anti-human CCR4 immunotoxin for targeting human CCR4+ cells in vivo

(2015) Zhaohui Wang et al.   Molecular Oncology

Foxp3+ T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation

(2015) B-H Yang et al.   Mucosal Immunology

Depletion of fat-resident Treg cells prevents age-associated insulin resistance

(2015) Sagar P. Bapat et al.   NATURE

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells

(2015) Ajithkumar Vasanthakumar et al.   NATURE IMMUNOLOGY

Brown Adipose Tissue Harbors a Distinct Sub-Population of Regulatory T Cells

(2015) Dasa Medrikova et al.   PLoS One

Individual intestinal symbionts induce a distinct population of ROR + regulatory T cells

(2015) E. Sefik et al.   SCIENCE

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

Anti-CCR4 monoclonal antibody enhances antitumor immunity by modulating tumor-infiltrating Tregs in an ovarian cancer xenograft humanized mouse model

(2015) De-Kuan Chang et al.   OncoImmunology

Human Blood and Mucosal Regulatory T Cells Express Activation Markers and Inhibitory Receptors in Inflammatory Bowel Disease

(2015) James D. Lord et al.   PLoS One

DNA hypermethylation of the forkhead box protein 3 (FOXP3) promoter in CD4+ T cells of patients with systemic sclerosis

(2014) Y.Y. Wang et al.   BRITISH JOURNAL OF DERMATOLOGY

Oral Interleukin-10 Alleviates Polyposis via Neutralization of Pathogenic T-Regulatory Cells

(2014) A. Y. Chung et al.   CANCER RESEARCH

Foxp3 + CD4 + T Cells Improve Healing After Myocardial Infarction by Modulating Monocyte/Macrophage Differentiation

(2014) Johannes Weirather et al.   CIRCULATION RESEARCH

Tissue-Resident Memory T Cells

(2014) Jason M. Schenkel et al.   IMMUNITY

tTregs, pTregs, and iTregs: similarities and differences

(2014) Ethan M. Shevach et al.   IMMUNOLOGICAL REVIEWS

OX40 engagement depletes intratumoral Tregs via activating FcγRs, leading to antitumor efficacy

(2014) Yannick Bulliard et al.   IMMUNOLOGY AND CELL BIOLOGY

Memory regulatory T cells reside in human skin

(2014) Robert Sanchez Rodriguez et al.   JOURNAL OF CLINICAL INVESTIGATION

TLR4 regulates IFN-γ and IL-17 production by both thymic and induced Foxp3+ Tregs during intestinal inflammation

(2014) Anthony T. Cao et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The alarmin IL-33 promotes regulatory T-cell function in the intestine

(2014) Chris Schiering et al.   NATURE

Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy

(2014) S. A. Villalta et al.   Science Translational Medicine

FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability

(2014) Beatriz León et al.   Nature Communications

Extracellular Adenosine-Mediated Modulation of Regulatory T Cells

(2014) Akio Ohta et al.   Frontiers in Immunology

Adenomatous Polyps Are Driven by Microbe-Instigated Focal Inflammation and Are Controlled by IL-10-Producing T Cells

(2013) K. L. Dennis et al.   CANCER RESEARCH

A Special Population of Regulatory T Cells Potentiates Muscle Repair

(2013) Dalia Burzyn et al.   CELL

Increased Prevalence of Circulating Novel IL-17 Secreting Foxp3 Expressing CD4+ T Cells and Defective Suppressive Function of Circulating Foxp3+ Regulatory Cells Support Plasticity Between Th17 and Regulatory T Cells in Inflammatory Bowel Disease Patients

(2013) Aito Ueno et al.   INFLAMMATORY BOWEL DISEASES

Cutting Edge: Memory Regulatory T Cells Require IL-7 and Not IL-2 for Their Maintenance in Peripheral Tissues

(2013) I. K. Gratz et al.   JOURNAL OF IMMUNOLOGY

Antigen-Specific Memory Regulatory CD4+Foxp3+ T Cells Control Memory Responses to Influenza Virus Infection

(2013) E. L. Brincks et al.   JOURNAL OF IMMUNOLOGY

Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota

(2013) Anna Cebula et al.   NATURE

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

(2013) Laura K Mackay et al.   NATURE IMMUNOLOGY

Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk

(2013) Nana-Maria Wagner et al.   Obesity

Elevated Levels of CD4+CD25+FoxP3+ T Cells in Systemic Sclerosis Patients Contribute to the Secretion of IL-17 and Immunosuppression Dysfunction

(2013) Xinjuan Liu et al.   PLoS One

Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans

(2013) D. Sugiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation and Function of Induced Regulatory T Cells

(2013) Erica G. Schmitt et al.   Frontiers in Immunology

Semaphorin 7a+Regulatory T Cells Are Associated with Progressive Idiopathic Pulmonary Fibrosis and Are Implicated in Transforming Growth Factor-β1–induced Pulmonary Fibrosis

(2012) Ronald A. Reilkoff et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Tissue-Specific Stem Cells: Lessons from the Skeletal Muscle Satellite Cell

(2012) Andrew S. Brack et al.   Cell Stem Cell

Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs  -Cell Function

(2012) S. A. Long et al.   DIABETES

Depletion of Tregs for adoptive T-cell therapy using CD44 and CD137 as selection markers

(2012) Brian G Till et al.   Immunotherapy

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+T reg cells

(2012) Jonathan M. Weiss et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

(2012) Steven Z. Josefowicz et al.   NATURE

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

(2012) Daniela Cipolletta et al.   NATURE

Molecular Mechanisms of Treg-Mediated T Cell Suppression

(2012) Angelika Schmidt et al.   Frontiers in Immunology

Regulatory T Cells Accumulate in the Lung Allergic Inflammation and Efficiently Suppress T-Cell Proliferation but Not Th2 Cytokine Production

(2011) Lucas Faustino et al.   Clinical & Developmental Immunology

Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis

(2011) Daniela Fenoglio et al.   CLINICAL IMMUNOLOGY

Potential Role of Regulatory T Cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy

(2011) Kathrin Eller et al.   DIABETES

An Essential Role of the Transcription Factor GATA-3 for the Function of Regulatory T Cells

(2011) Yunqi Wang et al.   IMMUNITY

Regulatory T cells and Foxp3

(2011) Alexander Y. Rudensky   IMMUNOLOGICAL REVIEWS

GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice

(2011) Elizabeth A. Wohlfert et al.   JOURNAL OF CLINICAL INVESTIGATION

Foxp3+ Regulatory T Cells of Psoriasis Patients Easily Differentiate into IL-17A-Producing Cells and Are Found in Lesional Skin

(2011) H. Jorn Bovenschen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Influenza A Virus Infection Results in a Robust, Antigen-Responsive, and Widely Disseminated Foxp3+ Regulatory T Cell Response

(2011) R. J. Betts et al.   JOURNAL OF VIROLOGY

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

(2011) Andrea Facciabene et al.   NATURE

The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells

(2011) Erika Cretney et al.   NATURE IMMUNOLOGY

Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments

(2011) Chuanmin Wang et al.   TRANSPLANT IMMUNOLOGY

Regulatory T cells in the skin lesions and blood of patients with systemic sclerosis and morphoea

(2010) E. Antiga et al.   BRITISH JOURNAL OF DERMATOLOGY

Depletion of regulatory T cells by anti-GITR mAb as a novel mechanism for cancer immunotherapy

(2010) David Coe et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

(2010) Ye Zheng et al.   NATURE

Reduced skin homing by functional Treg in vitiligo

(2010) Jared Klarquist et al.   Pigment Cell & Melanoma Research

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Global Impairment of CD4+CD25+FOXP3+Regulatory T Cells in Idiopathic Pulmonary Fibrosis

(2009) Ioannis Kotsianidis et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

OX40 costimulation can abrogate Foxp3+regulatory T cell-mediated suppression of antitumor immunity

(2009) Naomi Kitamura et al.   INTERNATIONAL JOURNAL OF CANCER

Foxp3+ Regulatory T Cells, Th17 Effector Cells, and Cytokine Environment in Inflammatory Bowel Disease

(2009) Nicola Eastaff-Leung et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

New Insights into Mechanisms of Spontaneous Liver Transplant Tolerance: The Role of Foxp3-Expressing CD25+CD4+Regulatory T Cells

(2008) W. Li et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells

(2008) H. J. P. M. Koenen et al.   BLOOD

DNA methylation controls Foxp3 gene expression

(2008) Julia K. Polansky et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Foxp3+regulatory T cells maintain immune homeostasis in the skin

(2008) Jan C. Dudda et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Treg Depletion Inhibits Efficacy of Cancer Immunotherapy: Implications for Clinical Trials

(2008) James F. Curtin et al.   PLoS One

The Presence of Foxp3 Expressing T Cells Within Grafts of Tolerant Human Liver Transplant Recipients

(2008) Ying Li et al.   TRANSPLANTATION