Insulin signaling establishes a developmental trajectory of adipose regulatory T cells

Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF

(2020) Michael Delacher et al.   IMMUNITY

Sex-specific adipose tissue imprinting of regulatory T cells

(2020) Ajithkumar Vasanthakumar et al.   NATURE

The obesity-induced adipokine sST2 exacerbates adipose Treg and ILC2 depletion and promotes insulin resistance

(2020) Xu-Yun Zhao et al.   Science Advances

Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity

(2020) Thorsten Gnad et al.   Cell Metabolism

An Autocrine Circuit of IL-33 in Keratinocytes is Involved in the Progression of Psoriasis

(2020) Fanfan Zeng et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation

(2019) Ricardo J. Miragaia et al.   IMMUNITY

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Functional Phenotypic Diversity of Regulatory T Cells Remaining in Inflamed Skin

(2019) Ryoyo Ikebuchi et al.   Frontiers in Immunology

TCR Transgenic Mice Reveal Stepwise, Multi-site Acquisition of the Distinctive Fat-Treg Phenotype

(2018) Chaoran Li et al.   CELL

γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis

(2018) Ayano C. Kohlgruber et al.   NATURE IMMUNOLOGY

Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR

(2018) David Zemmour et al.   NATURE IMMUNOLOGY

Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection

(2018) Sue Tsai et al.   Cell Metabolism

The Insulin Receptor Plays a Critical Role in T Cell Function and Adaptive Immunity

(2017) Henrike J. Fischer et al.   JOURNAL OF IMMUNOLOGY

Perinatal Licensing of Thermogenesis by IL-33 and ST2

(2016) Justin I. Odegaard et al.   CELL

Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice

(2015) Dmitriy Kolodin et al.   Cell Metabolism

Brown and Beige Fat: Physiological Roles beyond Heat Generation

(2015) Shingo Kajimura et al.   Cell Metabolism

Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation

(2015) Ari B. Molofsky et al.   IMMUNITY

Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis

(2015) Labros Sidossis et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-33 Reverses an Obesity-Induced Deficit in Visceral Adipose Tissue ST2+T Regulatory Cells and Ameliorates Adipose Tissue Inflammation and Insulin Resistance

(2015) Jonathan M. Han et al.   JOURNAL OF IMMUNOLOGY

Depletion of fat-resident Treg cells prevents age-associated insulin resistance

(2015) Sagar P. Bapat et al.   NATURE

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells

(2015) Ajithkumar Vasanthakumar et al.   NATURE IMMUNOLOGY

Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity

(2014) Yajing Chu et al.   CELL RESEARCH

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

(2014) Jonathan R. Brestoff et al.   NATURE

Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors

(2014) Thorsten Gnad et al.   NATURE

Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue

(2014) Lydia Lynch et al.   NATURE IMMUNOLOGY

HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia

(2013) Matthew D. Galbraith et al.   CELL

Insulin Inhibits IL-10-Mediated Regulatory T Cell Function: Implications for Obesity

(2013) J. M. Han et al.   JOURNAL OF IMMUNOLOGY

CD39 and CD73 in immunity and inflammation

(2013) Luca Antonioli et al.   TRENDS IN MOLECULAR MEDICINE

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

(2012) Daniela Cipolletta et al.   NATURE

The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation

(2010) Sohail Malik et al.   NATURE REVIEWS GENETICS

Myeloid Cell-Restricted Insulin Receptor Deficiency Protects Against Obesity-Induced Inflammation and Systemic Insulin Resistance

(2010) Jan Mauer et al.   PLoS Genetics

Activation of a HIF1α-PPARγ Axis Underlies the Integration of Glycolytic and Lipid Anabolic Pathways in Pathologic Cardiac Hypertrophy

(2009) Jaya Krishnan et al.   Cell Metabolism

Mediator MED23 Links Insulin Signaling to the Adipogenesis Transcription Cascade

(2009) Wei Wang et al.   DEVELOPMENTAL CELL

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE