Ferroptosis and Tumor Drug Resistance: Current Status and Major Challenges

Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020

(2021) Wei Cao et al.   CHINESE MEDICAL JOURNAL

Erastin synergizes with cisplatin via ferroptosis to inhibit ovarian cancer growth in vitro and in vivo

(2021) Qi Cheng et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Quercetin and Its Nano-Scale Delivery Systems in Prostate Cancer Therapy: Paving the Way for Cancer Elimination and Reversing Chemoresistance

(2021) Yaseen Hussain et al.   Cancers

Induction of ferroptosis by ATF3 elevation alleviates cisplatin resistance in gastric cancer by restraining Nrf2/Keap1/xCT signaling

(2021) Dazhi Fu et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

KEAP1/NRF2 (NFE2L2) mutations in NSCLC – Fuel for a superresistant phenotype?

(2021) Wolfram C.M. Dempke et al.   LUNG CANCER

Aldo-Keto Reductases and Cancer Drug Resistance

(2021) Trevor M. Penning et al.   PHARMACOLOGICAL REVIEWS

Ferroptosis: At the Crossroad of Gemcitabine Resistance and Tumorigenesis in Pancreatic Cancer

(2021) Jianhui Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Author Correction: Guidelines and definitions for research on epithelial–mesenchymal transition

(2021) Jing Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epigenetic Mechanisms of Resistance to Immune Checkpoint Inhibitors

(2020) Alexandre Perrier et al.   Biomolecules

Ferroptosis: molecular mechanisms and health implications

(2020) Daolin Tang et al.   CELL RESEARCH

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

(2019) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Emerging Role of Ferroptosis in Acute Kidney Injury

(2019) Zhaoxin Hu et al.   Oxidative Medicine and Cellular Longevity

Ferroptosis in Carcinoma: Regulatory Mechanisms and New Method for Cancer Therapy

(2019) Zhi-Zhou Shi et al.   OncoTargets and Therapy

Simultaneous Fenton-like Ion Delivery and Glutathione Depletion by MnO2 -Based Nanoagent to Enhance Chemodynamic Therapy

(2018) Li-Sen Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues

(2018) Matilde Maiorino et al.   ANTIOXIDANTS & REDOX SIGNALING

Erythropoietin and Nrf2: key factors in the neuroprotection provided by apo-lactoferrin

(2018) E. T. Zakharova et al.   BIOMETALS

Mechanisms of resistance to immune checkpoint inhibitors

(2018) Russell W Jenkins et al.   BRITISH JOURNAL OF CANCER

Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress

(2018) Jennifer Tsoi et al.   CANCER CELL

A G3BP1-interacting lncRNA promotes ferroptosis and apoptosis in cancer via nuclear sequestration of p53

(2018) Chao Mao et al.   CANCER RESEARCH

The challenge of drug resistance in cancer treatment: a current overview

(2018) Michail Nikolaou et al.   CLINICAL & EXPERIMENTAL METASTASIS

Anti-Cancer Compounds Targeted to VDAC: Potential and Perspectives

(2018) Simona Reina et al.   CURRENT MEDICINAL CHEMISTRY

Upregulation and activation of p53 by erastin‑induced reactive oxygen species contribute to cytotoxic and cytostatic effects in A549 lung cancer cells

(2018) Chaoli Huang et al.   ONCOLOGY REPORTS

The ferroptosis inducer erastin irreversibly inhibits system xc− and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells

(2018) Mami Sato et al.   Scientific Reports

Ferroptosis: A Novel Anti-tumor Action for Cisplatin

(2018) Jipeng Guo et al.   Cancer Research and Treatment

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

(2018) Amy Tarangelo et al.   Cell Reports

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

(2018) Huizhong Feng et al.   PLOS BIOLOGY

The Role of Ferroptosis in Cancer Development and Treatment Response

(2018) Bin Lu et al.   Frontiers in Pharmacology

Development of a novel FePt-based multifunctional ferroptosis agent for high-efficiency anticancer therapy

(2018) Ludan Yue et al.   Nanoscale

Targeting oncogenic drivers in lung cancer: Recent progress, current challenges and future opportunities

(2018) Satoshi Yoda et al.   PHARMACOLOGY & THERAPEUTICS

Iron and Alzheimer’s Disease: From Pathogenesis to Therapeutic Implications

(2018) Jun-Lin Liu et al.   Frontiers in Neuroscience

Ferrous-Supply-Regeneration Nanoengineering for Cancer-Cell-Specific Ferroptosis in Combination with Imaging-Guided Photodynamic Therapy

(2018) Tao Liu et al.   ACS Nano

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

(2018) Daiha Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Immunotherapy in managing metastatic melanoma: which treatment when?

(2017) Teresa Amaral et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Reactive oxygen species and cancer paradox: To promote or to suppress?

(2017) Sehamuddin Galadari et al.   FREE RADICAL BIOLOGY AND MEDICINE

Iron and ferroptosis: A still ill-defined liaison

(2017) Sebastian Doll et al.   IUBMB LIFE

Protein–protein interaction networks as a new perspective to evaluate distinct functional roles of voltage-dependent anion channel isoforms

(2017) Marianna Caterino et al.   Molecular BioSystems

NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression

(2017) Delin Chen et al.   MOLECULAR CELL

Enhanced Cisplatin Chemotherapy by Iron Oxide Nanocarrier-Mediated Generation of Highly Toxic Reactive Oxygen Species

(2017) Ping’an Ma et al.   NANO LETTERS

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers

(2017) Collin M Blakely et al.   NATURE GENETICS

Persistent bacterial infections and persister cells

(2017) Robert A. Fisher et al.   NATURE REVIEWS MICROBIOLOGY

Tracking the Evolution of Non–Small-Cell Lung Cancer

(2017) Mariam Jamal-Hanjani et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

(2017) Yangchun Xie et al.   Cell Reports

Aberrant corticosteroid metabolism in tumor cells enables GR takeover in enzalutamide resistant prostate cancer

(2017) Jianneng Li et al.   eLife

MiR-375/SLC7A11 axis regulates oral squamous cell carcinoma proliferation and invasion

(2017) Yadong Wu et al.   Cancer Medicine

The role of hypoxia on the acquisition of epithelial-mesenchymal transition and cancer stemness: a possible link to epigenetic regulation

(2017) Chang Dong Yeo et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis

(2017) Jong-Lyel Roh et al.   Redox Biology

Evolution of Voltage-Dependent Anion Channel Function: From Molecular Sieve to Governator to Actuator of Ferroptosis

(2017) John J. Lemasters   Frontiers in Oncology

VDAC–Tubulin, an Anti-Warburg Pro-Oxidant Switch

(2017) Eduardo N. Maldonado   Frontiers in Oncology

The Roles of NRF2 in Modulating Cellular Iron Homeostasis

(2017) Michael John Kerins et al.   ANTIOXIDANTS & REDOX SIGNALING

CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oct4 plays a crucial role in the maintenance of gefitinib-resistant lung cancer stem cells

(2016) Isao Kobayashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors

(2016) Lucy Ireland et al.   CANCER RESEARCH

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Simultaneous Determination of Cytochrome P450 Oxidation Capacity in Humans: A Review on the Phenotyping Cocktail Approach

(2016) Fernando Andrés et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis

(2016) Xiaofang Sun et al.   HEPATOLOGY

Confocal fluorescence microscopy to evaluate changes in adipocytes in the tumor microenvironment associated with invasive ductal carcinoma and ductal carcinomain situ

(2016) Jessica L. Dobbs et al.   INTERNATIONAL JOURNAL OF CANCER

Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid–Induced AKI

(2016) Diego Martin-Sanchez et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hypoxia inhibits mesenchymal stem cell proliferation through HIF1α-dependent regulation of P27

(2016) Sanjay Kumar et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Switching Apoptosis to Ferroptosis: Metal–Organic Network for High-Efficiency Anticancer Therapy

(2016) Di-Wei Zheng et al.   NANO LETTERS

Oxidized PEs trigger death

(2016) Katharina D'Herde et al.   Nature Chemical Biology

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

(2016) Maia Vinogradova et al.   Nature Chemical Biology

Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition

(2016) Aaron N Hata et al.   NATURE MEDICINE

Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

(2016) Sung Eun Kim et al.   Nature Nanotechnology

Regulated necrosis: disease relevance and therapeutic opportunities

(2016) Marcus Conrad et al.   NATURE REVIEWS DRUG DISCOVERY

Activation ofSAT1engages polyamine metabolism with p53-mediated ferroptotic responses

(2016) Yang Ou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Desferal regulates hCtr1 and transferrin receptor expression through Sp1 and exhibits synergistic cytotoxicity with platinum drugs in oxaliplatin-resistant human cervical cancer cells in vitro and in vivo

(2016) Szu-Jung Chen et al.   Oncotarget

Epigenetic changes mediated by polycomb repressive complex 2 and E2a are associated with drug resistance in a mouse model of lymphoma

(2016) Colin Flinders et al.   Genome Medicine

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

Depletion of the polyamines spermidine and spermine by overexpression of spermidine/spermineN1-acetyltransferase 1 (SAT1) leads to mitochondria-mediated apoptosis in mammalian cells

(2015) Swati Mandal et al.   BIOCHEMICAL JOURNAL

Role of race in oncogenic driver prevalence and outcomes in lung adenocarcinoma: Results from the Lung Cancer Mutation Consortium

(2015) Conor E. Steuer et al.   CANCER

Elucidating Compound Mechanism of Action by Network Perturbation Analysis

(2015) Jung Hoon Woo et al.   CELL

The miR-17-92 cluster counteracts quiescence and chemoresistance in a distinct subpopulation of pancreatic cancer stem cells

(2015) Michele Cioffi et al.   GUT

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Epigenetic Changes of EGFR Have an Important Role in BRAF Inhibitor–Resistant Cutaneous Melanomas

(2015) Jinhua Wang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Increased drug resistance in breast cancer by tumor-associated macrophages through IL-10/STAT3/bcl-2 signaling pathway

(2015) Cuixia Yang et al.   MEDICAL ONCOLOGY

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Therapy-induced tumour secretomes promote resistance and tumour progression

(2015) Anna C. Obenauf et al.   NATURE

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

HSPB1 as a novel regulator of ferroptotic cancer cell death

(2015) X Sun et al.   ONCOGENE

Brain and Testis Accumulation of Regorafenib is Restricted by Breast Cancer Resistance Protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1)

(2015) Anita Kort et al.   PHARMACEUTICAL RESEARCH

Persisters unmasked

(2015) D. W. Holden   SCIENCE

Heterogeneity Underlies the Emergence of EGFRT790 Wild-Type Clones Following Treatment of T790M-Positive Cancers with a Third-Generation EGFR Inhibitor

(2015) Z. Piotrowska et al.   Cancer Discovery

Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

(2015) Min-Young Kwon et al.   Oncotarget

NF-κB-Activating Complex Engaged in Response to EGFR Oncogene Inhibition Drives Tumor Cell Survival and Residual Disease in Lung Cancer

(2015) Collin M. Blakely et al.   Cell Reports

Inhibition of mutant EGFR in lung cancer cells triggers SOX2-FOXO6-dependent survival pathways

(2015) S Michael Rothenberg et al.   eLife

Oncogenic RAS Mutants Confer Resistance of RMS13 Rhabdomyosarcoma Cells to Oxidative Stress-Induced Ferroptotic Cell Death

(2015) Christina Schott et al.   Frontiers in Oncology

Drug Resistance via Feedback Activation of Stat3 in Oncogene-Addicted Cancer Cells

(2014) Ho-June Lee et al.   CANCER CELL

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Reduced Expression of miRNA-27a Modulates Cisplatin Resistance in Bladder Cancer by Targeting the Cystine/Glutamate Exchanger SLC7A11

(2014) R. M. Drayton et al.   CLINICAL CANCER RESEARCH

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

ALDH1A1 Maintains Ovarian Cancer Stem Cell-Like Properties by Altered Regulation of Cell Cycle Checkpoint and DNA Repair Network Signaling

(2014) Erhong Meng et al.   PLoS One

A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors

(2014) D. J. Konieczkowski et al.   Cancer Discovery

Registered report: Widespread potential for growth factor-driven resistance to anticancer kinase inhibitors

(2014) Edward Greenfield et al.   eLife

Registered report: Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

(2014) David Blum et al.   eLife

Assessment of potential anti-cancer stem cell activity of marine algal compounds using an in vitro mammosphere assay

(2013) Jo-Anne de la Mare et al.   Cancer Cell International

Voltage-dependent Anion Channels Modulate Mitochondrial Metabolism in Cancer Cells

(2013) Eduardo N. Maldonado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Dysregulation of BMI1 and microRNA-16 collaborate to enhance an anti-apoptotic potential in the side population of refractory mantle cell lymphoma

(2013) K Teshima et al.   ONCOGENE

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Oxidants, antioxidants and the current incurability of metastatic cancers

(2013) J. Watson   Open Biology

Intratumor Heterogeneity: Evolution through Space and Time

(2012) C. Swanton   CANCER RESEARCH

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Epigenetic mechanisms in tumorigenesis, tumor cell heterogeneity and drug resistance

(2012) Roel H. Wilting et al.   DRUG RESISTANCE UPDATES

Adenovirus adenine nucleotide translocator-2 shRNA effectively induces apoptosis and enhances chemosensitivity by the down-regulation of ABCG2 in breast cancer stem-like cells

(2012) Ji-Young Jang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population

(2012) Hasan Korkaya et al.   MOLECULAR CELL

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

Oncogenic and Wild-type Ras Play Divergent Roles in the Regulation of Mitogen-Activated Protein Kinase Signaling

(2012) Amy Young et al.   Cancer Discovery

Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages

(2011) Nobuhiko Harada et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines

(2011) Lu Cao et al.   BMC GASTROENTEROLOGY

Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles

(2011) Abena S. Agyeman et al.   BREAST CANCER RESEARCH AND TREATMENT

System xc- cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS

(2011) Richard J Bridges et al.   BRITISH JOURNAL OF PHARMACOLOGY

Immune microenvironments in solid tumors: new targets for therapy

(2011) S. L. Shiao et al.   GENES & DEVELOPMENT

Intrinsic gemcitabine resistance in a novel pancreatic cancer cell line is associated with cancer stem cell-like phenotype

(2011) Xiaoran Qin   INTERNATIONAL JOURNAL OF ONCOLOGY

How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine

(2010) M Gerlinger et al.   BRITISH JOURNAL OF CANCER

Free Tubulin Modulates Mitochondrial Membrane Potential in Cancer Cells

(2010) E. N. Maldonado et al.   CANCER RESEARCH

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

DNA Damage-Mediated Induction of a Chemoresistant Niche

(2010) Luke A. Gilbert et al.   CELL

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-inducible factors in stem cells and cancer

(2009) Jolly Mazumdar et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration

(2008) T. K. Rostovtseva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

(2008) C.-H. Yun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA