Review
Biochemistry & Molecular Biology
Chen Zhang, Xinyin Liu, Shidai Jin, Yi Chen, Renhua Guo
Summary: Ferroptosis, an iron-dependent form of cell death, plays a crucial role in tumor suppression and has the potential to reverse cancer therapy resistance.
Review
Oncology
Hong-Tao Wang, Jie Ju, Shao-Cong Wang, Yu-Hui Zhang, Cui-Yun Liu, Tao Wang, Xue Yu, Fei Wang, Xue-Ru Cheng, Kun Wang, Zhao-Yang Chen
Summary: Ferroptosis is a novel form of cell death characterized by iron accumulation and redox imbalance. It has unique morphological and biochemical features and shows great potential in cancer treatment. Small molecules based on research by Brent R. Stockwell's lab have been developed to induce ferroptosis in cancer cells, and some FDA-approved drugs have been found to trigger ferroptosis as well. Radiotherapy and checkpoint therapy have also been found to induce ferroptosis, providing new strategies for cancer treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yi Zheng, Xin Li, Caihong Dong, Li Ding, Hui Huang, Tianhu Zhang, Yu Chen, Rong Wu
Summary: The study demonstrates an ultrasound-augmented nanocatalytic ferroptosis strategy that reverses tumor chemotherapeutic resistance and induces synergistic ferroptosis/apoptosis therapy.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Guangxiang Xu, Han Wang, Xiaoling Li, Riming Huang, Lianxiang Luo
Summary: Ferroptosis is a novel mode of cell death that has become a target for antitumor therapy. Research has identified various mechanisms regulating the sensitivity of cancer cells to ferroptosis, and progress has been made in exploring ferroptosis-related drugs.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yi Xiao, Dihua Yu
Summary: This article summarizes the current progress in targeting the tumor microenvironment in both drug development and clinical trials, emphasizing the challenges in intervening in the tumor microenvironment and discussing strategies to maximize therapeutic benefits. New technologies and approaches to better understand the tumor microenvironment are explored in this context.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Pharmacology & Pharmacy
Zi'an Wang, Yueqin Wang, Zeyun Li, Wenhua Xue, Shousen Hu, Xiangzhen Kong
Summary: Cancer is the leading cause of human death today and its treatment process is complex. Drug resistance is a significant issue in cancer treatment, and lipid metabolism has been found to be closely related to drug resistance. Combination therapy may reverse the development of drug resistance and enhance sensitivity to therapeutic drugs.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Tingting Hu, Hanlin Gong, Jiayue Xu, Yuan Huang, Fengbo Wu, Zhiyao He
Summary: This paper reviews the mechanisms of cancer drug resistance to chemotherapy, targeted therapy, and immunotherapy, and discusses the latest developments in nanomedicines for overcoming cancer drug resistance.
Review
Oncology
Chu Xiao, Tao Fan, Yujia Zheng, He Tian, Ziqin Deng, Jingjing Liu, Chunxiang Li, Jie He
Summary: With the advancements in cancer immunity research, it has been discovered that histone modifications play a crucial role in establishing antitumor immunological ability. Combining epigenetic drugs with immune checkpoint blockades or chimeric antigen receptor-T cell therapies shows promise in improving immunotherapy outcomes. The specific histone modification, H3K4me3, is deeply involved in regulating tumor immunogenicity, reshaping tumor immune microenvironment, and regulating immune cell functions. However, there is still uncertainty in integrating these theoretical foundations and optimizing available therapies. This review explores the mechanisms by which H3K4me3 and its modifiers regulate antitumor immunity and discusses the potential of combining H3K4me3-related agents with immunotherapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biotechnology & Applied Microbiology
Rui Wang, Changming Zhao, Shuxia Jiang, Zhaohua Zhang, Chunmei Ban, Guiping Zheng, Yan Hou, Bingjin Jin, Yannan Shi, Xin Wu, Qiangqiang Zhao
Summary: This study provides a comprehensive overview of the application of nanoparticles in leukemia research, including diagnosis, treatment, and molecular mechanisms. It offers valuable references for researchers interested in nanoparticles-leukemia.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Ganji Seeta Rama Raju, Eluri Pavitra, Ganji Lakshmi Varaprasad, Sai Samyuktha Bandaru, Ganji Purnachandra Nagaraju, Batoul Farran, Yun Suk Huh, Young-Kyu Han
Summary: The tumor microenvironment (TME) is crucial in cancer development and drug resistance. Nano-based approaches offer advantages for targeting and reprogramming abnormal TME components, improving clinical outcomes in cancer treatment.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Cell Biology
Siyuan Luan, Xiaoxi Zeng, Chao Zhang, Jiajun Qiu, Yushang Yang, Chengyi Mao, Xin Xiao, Jianfeng Zhou, Yonggang Zhang, Yong Yuan
Summary: Drug resistance is a major obstacle for esophageal cancer patients to achieve maximum therapeutic benefit, and it is closely related to the interaction between tumor cells and the tumor microenvironment. Targeting both tumor cells and tumor-favorable microenvironment through combination therapy is a promising strategy to overcome drug resistance in esophageal cancer and improve therapeutic responses for patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Xiang Liu, Shaowen Du, Shengdong Wang, Kaishan Ye
Summary: This paper reviews the regulatory mechanism and research progress of ferroptosis in osteosarcoma, providing new insights for clinical treatment.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Shenghua Zhuo, Guiying He, Taixue Chen, Xiang Li, Yunheng Liang, Wenkai Wu, Lingxiao Weng, Jigao Feng, Zhenzhong Gao, Kun Yang
Summary: Glioblastoma (GBM) is a common malignant brain tumor with high heterogeneity and an immunosuppressive microenvironment, making its treatment difficult. Ferroptosis, a newly discovered non-apoptotic cell death process, plays a crucial role in GBM therapies. Targeting ferroptosis may be an effective strategy to overcome resistance to tumor therapy and immune escape mechanisms.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Cell Biology
Chengyi Mao, Xiaoxi Zeng, Chao Zhang, Yushang Yang, Xin Xiao, Siyuan Luan, Yonggang Zhang, Yong Yuan
Summary: Pharmaceutical therapies play a crucial role in the treatment of esophageal cancer, with neoadjuvant therapy being effective for advanced cases. However, pharmaceutical treatment still faces limitations such as side effects and drug resistance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Shilang Xiao, Xiaoming Liu, Lingzhi Yuan, Xiao Chen, Fen Wang
Summary: This study revealed that by varying the activation degrees of ferroptosis, tumor cells and their surrounding microenvironment could be shaped. Establishing ferroptosis-related subtypes would guide in predicting the biological features of individual tumors and selecting appropriate treatment protocols for patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Xiaoyang Yang, Shufang Zhang, Denggao Huang, Zhiming Wang, Xiaoxia Chen, Xiansheng Luo, Meiqing Lei, Feng Yu, Xiaobo Chen, Peilong Huang
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2019)
Article
Materials Science, Multidisciplinary
Denggao Huang, Hui Cao, Lifang Guo, Yuanhui Gao, Linlin Zheng, Xiaohong Wen, Xiaolong Yu, Shufang Zhang
Article
Engineering, Biomedical
Hui Cao, Denggao Huang, Lifang Guo, Yuanhui Gao, Linlin Zheng, Jingchuan Xiao, Shufang Zhang, Xiaolong Yu
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2020)
Article
Multidisciplinary Sciences
Denggao Huang, Yuanhui Gao, Shunlan Wang, Wei Zhang, Hui Cao, Linlin Zheng, Yang Chen, Shufang Zhang, Jie Chen
SCIENTIFIC REPORTS
(2020)
Review
Cell Biology
Zhenyu Nie, Mei Chen, Xiaohong Wen, Yuanhui Gao, Denggao Huang, Hui Cao, Yanling Peng, Na Guo, Jie Ni, Shufang Zhang
Summary: Bladder cancer is a common malignant tumor of the urinary system, and research related to tumor microenvironment and endoplasmic reticulum stress is crucial for improving treatment outcomes. The challenge lies in overcoming therapeutic resistance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Zhenyu Nie, Mei Chen, Yuanhui Gao, Denggao Huang, Hui Cao, Yanling Peng, Na Guo, Shufang Zhang
Summary: Urinary malignancies such as kidney, bladder, and prostate cancers pose challenges in treatment due to high recurrence and metastasis rates. The regulation of cell death pathways plays a significant role in the pathogenesis of these tumors, with various modes of regulated cell death influencing tumor progression and therapeutic responses. Targeting regulatory cell death pathways shows promise for improving outcomes in urinary system tumor treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Mei Chen, Zhenyu Nie, Denggao Huang, Yuanhui Gao, Hui Cao, Linlin Zheng, Shufang Zhang
Summary: This study reveals the correlation between polyamine metabolism and the immune microenvironment of clear cell renal cell carcinoma (ccRCC), and develops a polyamine gene expression score (PGES) that is associated with prognosis and immunotherapy response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yuanhui Gao, Zhenyu Nie, Hui Cao, Denggao Huang, Mei Chen, Yang Xiang, Xiaolong Yu, Shufang Zhang
Summary: Scabertopin, a major sesquiterpene lactone from Elephantopus scaber L., has been found to induce necroptosis in bladder cancer cells, inhibit migration and invasion, with a lower half-inhibition rate on bladder cancer cells compared to human ureteral epithelial immortalized cells.
Review
Oncology
Yuanhui Gao, Hui Cao, Denggao Huang, Linlin Zheng, Zhenyu Nie, Shufang Zhang
Summary: Bladder cancer is a commonly occurring malignant tumor in the urinary system. RBPs have been found to play a critical role in bladder cancer by regulating various processes involved in RNA splicing, translation, and stability. Understanding the regulatory mechanisms of RBPs in bladder cancer can provide valuable insights for the development of new therapies. This article reviews the research progress on RBPs in bladder cancer and aims to encourage attention and provide reference for clinicians and researchers interested in this field.
