A missense mutation sheds light on a novel structure–function relationship of RANKL

Cistanche deserticola polysaccharide attenuates osteoclastogenesis and bone resorption via inhibiting RANKL signaling and reactive oxygen species production

(2018) Dezhi Song et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Coupling of bone resorption and formation by RANKL reverse signalling

(2018) Yuki Ikebuchi et al.   NATURE

Osteoclast regulation of osteoblasts via RANK-RANKL reverse signal transduction in vitro

(2017) Shiqian Zhang et al.   Molecular Medicine Reports

DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation

(2017) Hyuk Soon Kim et al.   Nature Communications

Role of the RANK/RANKL pathway in breast cancer

(2016) Ludwig Kiesel et al.   MATURITAS

Proliferation-coupled osteoclast differentiation by RANKL: Cell density as a determinant of osteoclast formation

(2015) M. Motiur Rahman et al.   BONE

Osteoprotegerin is a Better Serum Biomarker of Coronary Artery Calcification than Osteocalcin in Type 2 Diabetes

(2015) Raelene Maser et al.   Endocrine Practice

Regulation of Osteoblast Migration Involving Receptor Activator of Nuclear Factor-kappa B (RANK) Signaling

(2015) Diana Golden et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A RANKL mutant used as an inter-species vaccine for efficient immunotherapy of osteoporosis

(2015) Changzhen Liu et al.   Scientific Reports

Residue mutations and their impact on protein structure and function: detecting beneficial and pathogenic changes

(2013) Romain A. Studer et al.   BIOCHEMICAL JOURNAL

Osteopetrosis: genetics, treatment and new insights into osteoclast function

(2013) Cristina Sobacchi et al.   Nature Reviews Endocrinology

Osteoprotegerin Enhances Osteogenesis of Human Mesenchymal Stem Cells

(2013) SunMi Palumbo et al.   TISSUE ENGINEERING PART A

RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy Receptor

(2012) Christopher A. Nelson et al.   STRUCTURE

Osteoprotegerin and Diabetes-Associated Pathologies

(2011) A. M. Blazquez-Medela et al.   CURRENT MOLECULAR MEDICINE

Osteoprotegerin is associated with cardiovascular risk in hypertension and/or diabetes

(2011) Ana M. Blázquez-Medela et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF

(2011) Eleni Douni et al.   HUMAN MOLECULAR GENETICS

RANK-dependent autosomal recessive osteopetrosis: Characterization of five new cases with novel mutations

(2011) Alessandra Pangrazio et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Treatment with Denosumab Reduces the Incidence of New Vertebral and Hip Fractures in Postmenopausal Women at High Risk

(2011) S. Boonen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Calcium signaling in osteoclasts

(2010) Sung-Yong Hwang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Effects of denosumab on bone turnover markers in postmenopausal osteoporosis

(2010) Richard Eastell et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Structural and Functional Insights of RANKL-RANK Interaction and Signaling

(2010) C. Liu et al.   JOURNAL OF IMMUNOLOGY

Osteoprotegerin as a Predictor of Coronary Artery Disease and Cardiovascular Mortality and Morbidity

(2010) Shreenidhi M. Venuraju et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Structure-based development of a receptor activator of nuclear factor- B ligand (RANKL) inhibitor peptide and molecular basis for osteopetrosis

(2010) H. M. Ta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Central control of fever and female body temperature by RANKL/RANK

(2009) Reiko Hanada et al.   NATURE

Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis

(2009) Steven R. Cummings et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human Osteoclast-Poor Osteopetrosis with Hypogammaglobulinemia due to TNFRSF11A (RANK) Mutations

(2008) Matteo M. Guerrini et al.   AMERICAN JOURNAL OF HUMAN GENETICS

NF-κB modulators in osteolytic bone diseases

(2008) Jiake Xu et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Mutations within the TNF-Like Core Domain of RANKL Impair Osteoclast Differentiation and Activation

(2008) Taksum Cheng et al.   MOLECULAR ENDOCRINOLOGY