Analyzing N-terminal Arginylation through the Use of Peptide Arrays and Degradation Assays

Degradation of the Separase-cleaved Rec8, a Meiotic Cohesin Subunit, by the N-end Rule Pathway

(2016) Yu-Jiao Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Degradation of SerotoninN-Acetyltransferase, a Circadian Regulator, by the N-end Rule Pathway

(2016) Brandon Wadas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Targets and Interaction Partners of Arginyl-tRNA Protein Transferase in the MossPhyscomitrella patens

(2016) Sebastian N. W. Hoernstein et al.   MOLECULAR & CELLULAR PROTEOMICS

N-Terminal Acetylation-Targeted N-End Rule Proteolytic System: The Ac/N-End Rule Pathway

(2016)   MOLECULES AND CELLS

The-N-End Rule: The Beginning Determines the End

(2016) Mohamed Eldeeb et al.   PROTEIN AND PEPTIDE LETTERS

Oxygen Sensing and Signaling

(2015) Joost T. van Dongen et al.   Annual Review of Plant Biology

The biological functions of Naa10 — From amino-terminal acetylation to human disease

(2015) Max J. Dörfel et al.   GENE

Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding

(2015) Hyunjoo Cha-Molstad et al.   NATURE CELL BIOLOGY

Quantitative proteomics analysis of the Arg/N-end rule pathway of targeted degradation in Arabidopsis roots

(2015) Hongtao Zhang et al.   PROTEOMICS

Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway

(2015) S.-E. Park et al.   SCIENCE

Arginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophosphate synthase

(2015) Fangliang Zhang et al.   Nature Communications

The anti-apoptotic form of tyrosine kinase Lyn that is generated by proteolysis is degraded by the N-end rule pathway

(2015) Mohamed A. Eldeeb et al.   Oncotarget

Arginyltransferase ATE1 Catalyzes Midchain Arginylation of Proteins at Side Chain Carboxylates In Vivo

(2014) Junling Wang et al.   CHEMISTRY & BIOLOGY

Paradigms of protein degradation by the proteasome

(2014) Tomonao Inobe et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Targeted Proteomics Analysis of Protein Degradation in Plant Signaling on an LTQ-Orbitrap Mass Spectrometer

(2014) Petra Majovsky et al.   JOURNAL OF PROTEOME RESEARCH

Nitric Oxide Sensing in Plants Is Mediated by Proteolytic Control of Group VII ERF Transcription Factors

(2014) Daniel J. Gibbs et al.   MOLECULAR CELL

Liat1, an arginyltransferase-binding protein whose evolution among primates involved changes in the numbers of its 10-residue repeats

(2014) Christopher S. Brower et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Remodeling of a delivery complex allows ClpS-mediated degradation of N-degron substrates

(2014) Izarys Rivera-Rivera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway

(2014) Konstantin I. Piatkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enzymatic generation of peptides flanked by basic amino acids to obtain MS/MS spectra with 2× sequence coverage

(2014) H. Alexander Ebhardt et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

The eukaryotic N-end rule pathway: conserved mechanisms and diverse functions

(2014) Daniel J. Gibbs et al.   TRENDS IN CELL BIOLOGY

Plant cysteine oxidases control the oxygen-dependent branch of the N-end-rule pathway

(2014) Daan A. Weits et al.   Nature Communications

Arginylation of Myosin Heavy Chain Regulates Skeletal Muscle Strength

(2014) Anabelle S. Cornachione et al.   Cell Reports

PINK1 is degraded through the N-end rule pathway

(2013) Koji Yamano et al.   Autophagy

The N-end rule proteolytic system in autophagy

(2013) Sung Tae Kim et al.   Autophagy

The N-Terminal Methionine of Cellular Proteins as a Degradation Signal

(2013) Heon-Ki Kim et al.   CELL

Signaling mechanism of tumor cell-induced up-regulation of E3 ubiquitin ligase UBR2

(2013) Guohua Zhang et al.   FASEB JOURNAL

The N-degradome ofEscherichia coli

(2013) Matthew A. Humbard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of Protein Quality and Stoichiometries by N-Terminal Acetylation and the N-End Rule Pathway

(2013) Anna Shemorry et al.   MOLECULAR CELL

Neurodegeneration-Associated Protein Fragments as Short-Lived Substrates of the N-End Rule Pathway

(2013) Christopher S. Brower et al.   MOLECULAR CELL

UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy

(2013) T. Tasaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The N-End Rule Pathway

(2012) Takafumi Tasaki et al.   Annual Review of Biochemistry

Biosynthetic mode can determine the mechanism of protein quality control

(2012) Rupali Prasad et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The type-2 N-end rule peptide recognition activity of Ubr11 ubiquitin ligase is required for the expression of peptide transporters

(2012) Kenji Kitamura et al.   FEBS LETTERS

A Network of Ubiquitin Ligases Is Important for the Dynamics of Misfolded Protein Aggregates in Yeast

(2012) Maria A. Theodoraki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The C-terminal Proteolytic Fragment of the Breast Cancer Susceptibility Type 1 Protein (BRCA1) Is Degraded by the N-end Rule Pathway

(2012) Zhizhong Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arginylation-dependent regulation of a proteolytic product of talin is essential for cell–cell adhesion

(2012) Fangliang Zhang et al.   JOURNAL OF CELL BIOLOGY

Arginylation regulates myofibrils to maintain heart function and prevent dilated cardiomyopathy

(2012) Satoshi Kurosaka et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Auto-Generated Fragment of the Usp1 Deubiquitylase Is a Physiological Substrate of the N-End Rule Pathway

(2012) Konstantin I. Piatkov et al.   MOLECULAR CELL

UBR2 of the N-End Rule Pathway Is Required for Chromosome Stability via Histone Ubiquitylation in Spermatocytes and Somatic Cells

(2012) Jee Young An et al.   PLoS One

The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments

(2012) K. I. Piatkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: a hypothesis

(2012) Alexander Varshavsky   PROTEIN SCIENCE

Protein N-terminal acetyltransferases: when the start matters

(2012) Kristian K. Starheim et al.   TRENDS IN BIOCHEMICAL SCIENCES

The N-end rule pathway: From recognition by N-recognins, to destruction by AAA+proteases

(2011) D.A. Dougan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Application of Celluspots peptide arrays for the analysis of the binding specificity of epigenetic reading domains to modified histone tails

(2011) Ina Bock et al.   BMC BIOCHEMISTRY

Arginylation and Methylation Double Up to Regulate Nuclear Proteins and Nuclear Architecture In Vivo

(2011) Sougata Saha et al.   CHEMISTRY & BIOLOGY

Arginyltransferase Is an ATP-Independent Self-Regulating Enzyme that Forms Distinct Functional Complexes In Vivo

(2011) Junling Wang et al.   CHEMISTRY & BIOLOGY

Detailed specificity analysis of antibodies binding to modified histone tails with peptide arrays

(2011) Ina Bock et al.   Epigenetics

UBR1 promotes protein kinase quality control and sensitizes cells to Hsp90 inhibition

(2011) Rasheda Sultana et al.   EXPERIMENTAL CELL RESEARCH

Oxygen sensing in plants is mediated by an N-end rule pathway for protein destabilization

(2011) Francesco Licausi et al.   NATURE

Plant Oxygen Sensing Is Mediated by the N-End Rule Pathway: A Milestone in Plant Anaerobiosis

(2011) R. Sasidharan et al.   PLANT CELL

Ubiquitin Ligases of the N-End Rule Pathway: Assessment of Mutations in UBR1 That Cause the Johanson-Blizzard Syndrome

(2011) Cheol-Sang Hwang et al.   PLoS One

The N-end rule pathway and regulation by proteolysis

(2011) Alexander Varshavsky   PROTEIN SCIENCE

Ubr1 and Ubr2 Function in a Quality Control Pathway for Degradation of Unfolded Cytosolic Proteins

(2010) Nadinath B. Nillegoda et al.   MOLECULAR BIOLOGY OF THE CELL

The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases

(2010) Cheol-Sang Hwang et al.   NATURE CELL BIOLOGY

Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases

(2010) Woo Suk Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of substrate recognition and specificity in the N-end rule pathway

(2010) Edna Matta-Camacho et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail

(2010) Yingying Zhang et al.   NUCLEIC ACIDS RESEARCH

The Ubiquitin Ligase Ubr2, a Recognition E3 Component of the N-End Rule Pathway, Stabilizes Tex19.1 during Spermatogenesis

(2010) Fang Yang et al.   PLoS One

UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination

(2010) J. Y. An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Arginylation of Actin Isoforms Is Regulated by Coding Sequence-Dependent Degradation

(2010) F. Zhang et al.   SCIENCE

N-Terminal Acetylation of Cellular Proteins Creates Specific Degradation Signals

(2010) C.-S. Hwang et al.   SCIENCE

The plant N-end rule pathway: structure and functions

(2010) Emmanuelle Graciet et al.   TRENDS IN PLANT SCIENCE

Arginylation-Dependent Neural Crest Cell Migration Is Essential for Mouse Development

(2010) Satoshi Kurosaka et al.   PLoS Genetics

Glutamine-Specific N-Terminal Amidase, a Component of the N-End Rule Pathway

(2009) Haiqing Wang et al.   MOLECULAR CELL

Identification of N-terminally arginylated proteins and peptides by mass spectrometry

(2009) Tao Xu et al.   Nature Protocols

Ablation of Arginylation in the Mouse N-End Rule Pathway: Loss of Fat, Higher Metabolic Rate, Damaged Spermatogenesis, and Neurological Perturbations

(2009) Christopher S. Brower et al.   PLoS One

Two proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase

(2009) C.-S. Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The N-end rule pathway promotes seed germination and establishment through removal of ABA sensitivity in Arabidopsis

(2009) T. J. Holman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1

(2009) J. W. Heck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arginyltransferase regulates alpha cardiac actin function, myofibril formation and contractility during heart development

(2008) R. Rai et al.   DEVELOPMENT

Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1

(2008) Frederik Eisele et al.   FEBS LETTERS

Discovery of Cellular Regulation by Protein Degradation

(2008) Alexander Varshavsky   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate-binding Sites of UBR1, the Ubiquitin Ligase of the N-end Rule Pathway

(2008) Zanxian Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amino Acids Induce Peptide Uptake via Accelerated Degradation of CUP9, the Transcriptional Repressor of the PTR2 Peptide Transporter

(2008) Zanxian Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of peptide import through phosphorylation of Ubr1, the ubiquitin ligase of the N-end rule pathway

(2008) C.-S. Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA