- Home
- Publications
- Publication Search
- Publication Details
Title
A Perspective on Late-Stage Aromatic C–H Bond Functionalization
Authors
Keywords
-
Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 144, Issue 6, Pages 2399-2414
Publisher
American Chemical Society (ACS)
Online
2022-01-27
DOI
10.1021/jacs.1c10783
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Electrophotocatalytic C–H Heterofunctionalization of Arenes
- (2021) He Huang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Late‐Stage Heteroarylation of Hetero(aryl)sulfonium Salts Activated by α‐Amino Alkyl Radicals
- (2021) Eva Maria Alvarez et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Sequential Ir/Cu-Mediated Method for the Meta-Selective C–H Radiofluorination of (Hetero)Arenes
- (2021) Jay S. Wright et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Phosphorus-mediated sp2-sp3 couplings for C–H fluoroalkylation of azines
- (2021) Xuan Zhang et al. NATURE
- Arene diversification through distal C(sp2)−H functionalization
- (2021) Uttam Dutta et al. SCIENCE
- Programmable late-stage C−H bond functionalization enabled by integration of enzymes with chemocatalysis
- (2021) Elliott J. Craven et al. Nature Catalysis
- Engineered and Artificial Metalloenzymes for Selective C–H Functionalization
- (2021) Xinkun Ren et al. Current Opinion in Green and Sustainable Chemistry
- Site-Selective C–H alkylation of Complex Arenes by a Two-Step Aryl Thianthrenation-Reductive Alkylation Sequence
- (2021) Beatrice Lansbergen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- High Site Selectivity in Electrophilic Aromatic Substitutions: Mechanism of C–H Thianthrenation
- (2021) Fabio Juliá et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A radical approach for the selective C–H borylation of azines
- (2021) Ji Hye Kim et al. NATURE
- Site-selective tyrosine bioconjugation via photoredox catalysis for native-to-bioorthogonal protein transformation
- (2021) Beryl X. Li et al. Nature Chemistry
- Transition-Metal-Free, Formal C–H Germylation of Arenes and Styrenes via Dibenzothiophenium Salts
- (2021) Aymane Selmani et al. ORGANIC LETTERS
- A tautomeric ligand enables directed C‒H hydroxylation with molecular oxygen
- (2021) Zhen Li et al. SCIENCE
- Radical philicity and its role in selective organic transformations
- (2021) Faeze Parsaee et al. Nature Reviews Chemistry
- Late-stage C–H functionalization offers new opportunities in drug discovery
- (2021) Lucas Guillemard et al. Nature Reviews Chemistry
- Photoredox-Catalyzed C–H Functionalization Reactions
- (2021) Natalie Holmberg-Douglas et al. CHEMICAL REVIEWS
- Tritiation of aryl thianthrenium salts with a molecular palladium catalyst
- (2021) Da Zhao et al. NATURE
- Site-Selective C–H Functionalization via Synergistic Use of Electrochemistry and Transition Metal Catalysis
- (2020) Ke-Jin Jiao et al. ACCOUNTS OF CHEMICAL RESEARCH
- Differentiation and functionalization of remote C–H bonds in adjacent positions
- (2020) Hang Shi et al. Nature Chemistry
- Achieving Site-Selectivity for C–H Activation Processes Based on Distance and Geometry: A Carpenter’s Approach
- (2020) Guangrong Meng et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Cobalt-catalysed C–H methylation for late-stage drug diversification
- (2020) Stig D. Friis et al. Nature Chemistry
- Site-Selective C–H Functionalization–Sulfination Sequence to Access Aryl Sulfonamides
- (2020) Eva Maria Alvarez et al. ORGANIC LETTERS
- Germylation of Arenes via Pd(I) Dimer Enabled Sulfonium Salt Functionalization
- (2020) Aymane Selmani et al. ORGANIC LETTERS
- Late-Stage Functionalization
- (2020) Jonas Börgel et al. Chem
- Site-selective and versatile aromatic C−H functionalization by thianthrenation
- (2019) Florian Berger et al. NATURE
- Recent Advances in Minisci-Type Reactions
- (2019) Rupert S. J. Proctor et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Palladium/Norbornene Cooperative Catalysis
- (2019) Jianchun Wang et al. CHEMICAL REVIEWS
- Direct arene C–H fluorination with 18F− via organic photoredox catalysis
- (2019) Wei Chen et al. SCIENCE
- C–N Cross-Couplings for Site-Selective Late-Stage Diversification via Aryl Sulfonium Salts
- (2019) Pascal S. Engl et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Electrophotocatalysis with a Trisaminocyclopropenium Radical Dication
- (2019) He Huang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Aryl Sulfonium Salts for Site-Selective Late-Stage Trifluoromethylation
- (2019) Fei Ye et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Site-Selective C−H Oxygenation via Aryl Sulfonium Salts
- (2019) Ruocheng Sang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Photoredox catalysis with aryl sulfonium salts enables site-selective late-stage fluorination
- (2019) Jiakun Li et al. Nature Chemistry
- Para-selective borylation of monosubstituted benzenes using a transient mediator
- (2019) Jie Wu et al. Science China-Chemistry
- A Survival Guide for the “Electro-curious”
- (2019) Cian Kingston et al. ACCOUNTS OF CHEMICAL RESEARCH
- Synthetic Photoelectrochemistry
- (2019) Joshua Philip Barham et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Site-Selective Late-Stage Aromatic [18 F]Fluorination via Aryl Sulfonium Salts
- (2019) Peng Xu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Triptycenyl Sulfide: A Practical and Active Catalyst for Electrophilic Aromatic Halogenation Using N-Halosuccinimides
- (2019) Yuji Nishii et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Asymmetric redox-neutral radical cyclization catalysed by flavin-dependent ‘ene’-reductases
- (2019) Michael J. Black et al. Nature Chemistry
- Transition-Metal-Catalyzed Selective Functionalization of C(sp3 )−H Bonds in Natural Products
- (2018) Rashad R. Karimov et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Photoredox Catalysis for Building C–C Bonds from C(sp2)–H Bonds
- (2018) Chang-Sheng Wang et al. CHEMICAL REVIEWS
- A General Strategy for Site-Selective Incorporation of Deuterium and Tritium into Pyridines, Diazines, and Pharmaceuticals
- (2018) J. Luke Koniarczyk et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Cyclometallated ruthenium catalyst enables late-stage directed arylation of pharmaceuticals
- (2018) Marco Simonetti et al. Nature Chemistry
- A comprehensive overview of directing groups applied in metal-catalysed C–H functionalisation chemistry
- (2018) Carlo Sambiagio et al. CHEMICAL SOCIETY REVIEWS
- Palladium-catalysed electrophilic aromatic C–H fluorination
- (2018) Kumiko Yamamoto et al. NATURE
- Electrochemically Promoted Tyrosine-Click-Chemistry for Protein Labeling
- (2018) Dimitri Alvarez-Dorta et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Late-Stage Aromatic C–H Oxygenation
- (2018) Jonas Börgel et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Palladium-Catalyzed Late-Stage Direct Arene Cyanation
- (2018) Da Zhao et al. Chem
- Selective C H bond functionalization with engineered heme proteins: new tools to generate complexity
- (2018) Ruijie K Zhang et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- C(sp2)–H Borylation of Fluorinated Arenes Using an Air-Stable Cobalt Precatalyst: Electronically Enhanced Site Selectivity Enables Synthetic Opportunities
- (2017) Jennifer V. Obligacion et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Remote site-selective C–H activation directed by a catalytic bifunctional template
- (2017) Zhipeng Zhang et al. NATURE
- Ligand-accelerated non-directed C–H functionalization of arenes
- (2017) Peng Wang et al. NATURE
- 4-Selective Pyridine Functionalization Reactions via Heterocyclic Phosphonium Salts
- (2017) Andrew McNally et al. SYNLETT
- Accessing Drug Metabolites via Transition-Metal Catalyzed C−H Oxidation: The Liver as Synthetic Inspiration
- (2016) Julien Genovino et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- The medicinal chemist's toolbox for late stage functionalization of drug-like molecules
- (2016) Tim Cernak et al. CHEMICAL SOCIETY REVIEWS
- Cobalt-Catalyzed C(sp2)-H Borylation: Mechanistic Insights Inspire Catalyst Design
- (2016) Jennifer V. Obligacion et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Selective Functionalization of Pyridines via Heterocyclic Phosphonium Salts
- (2016) Michael C. Hilton et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Radicals: Reactive Intermediates with Translational Potential
- (2016) Ming Yan et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Iron-catalysed tritiation of pharmaceuticals
- (2016) Renyuan Pony Yu et al. NATURE
- Charge-transfer-directed radical substitution enables para-selective C–H functionalization
- (2016) Gregory B. Boursalian et al. Nature Chemistry
- Iridium-Catalyzed Silylation of Aryl C–H Bonds
- (2015) Chen Cheng et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- para-C–H Borylation of Benzene Derivatives by a Bulky Iridium Catalyst
- (2015) Yutaro Saito et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Radical CH Functionalization of Heteroarenes under Electrochemical Control
- (2014) Alexander G. O'Brien et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Synthesis of Extended π-Systems through C-H Activation
- (2014) Yasutomo Segawa et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Transition-Metal-Free Coupling Reactions
- (2014) Chang-Liang Sun et al. CHEMICAL REVIEWS
- Cobalt-Catalyzed C–H Borylation
- (2014) Jennifer V. Obligacion et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Rhodium-Catalyzed Intermolecular C-H Silylation of Arenes with High Steric Regiocontrol
- (2014) C. Cheng et al. SCIENCE
- Ligand-Directed Selective Protein Modification Based on Local Single-Electron-Transfer Catalysis
- (2013) Shinichi Sato et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
- (2013) Jiang Wang et al. CHEMICAL REVIEWS
- Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis
- (2013) Christopher K. Prier et al. CHEMICAL REVIEWS
- Photocatalytic Monofluorination of Benzene by Fluoride via Photoinduced Electron Transfer with 3-Cyano-1-methylquinolinium
- (2013) Kei Ohkubo et al. JOURNAL OF PHYSICAL CHEMISTRY A
- Visible-Light-Induced Oxygenation of Benzene by the Triplet Excited State of 2,3-Dichloro-5,6-dicyano-p-benzoquinone
- (2013) Kei Ohkubo et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Cu(OTf)2-Mediated Fluorination of Aryltrifluoroborates with Potassium Fluoride
- (2013) Yingda Ye et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Metal-free oxidation of aromatic carbon–hydrogen bonds through a reverse-rebound mechanism
- (2013) Changxia Yuan et al. NATURE
- C–H bond activation enables the rapid construction and late-stage diversification of functional molecules
- (2013) Joanna Wencel-Delord et al. Nature Chemistry
- CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals
- (2012) Junichiro Yamaguchi et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Use of Radiolabeled Compounds in Drug Metabolism and Pharmacokinetic Studies
- (2012) Emre M. Isin et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Synthesis of Pyridine and Dihydropyridine Derivatives by Regio- and Stereoselective Addition to N-Activated Pyridines
- (2012) James A. Bull et al. CHEMICAL REVIEWS
- Practical and innate carbon–hydrogen functionalization of heterocycles
- (2012) Yuta Fujiwara et al. NATURE
- Modern Molecular Photochemistry of Organic Molecules
- (2012) Nicholas J. Turro et al. PHOTOCHEMISTRY AND PHOTOBIOLOGY
- Innate and Guided C–H Functionalization Logic
- (2011) Tobias Brückl et al. ACCOUNTS OF CHEMICAL RESEARCH
- Weak Coordination as a Powerful Means for Developing Broadly Useful C–H Functionalization Reactions
- (2011) Keary M. Engle et al. ACCOUNTS OF CHEMICAL RESEARCH
- Positron emission tomography molecular imaging for drug development
- (2011) Paul M. Matthews et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Controlling Site Selectivity in Pd-Catalyzed Oxidative Cross-Coupling Reactions
- (2011) Thomas W. Lyons et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Divergent C–H Functionalizations Directed by Sulfonamide Pharmacophores: Late-Stage Diversification as a Tool for Drug Discovery
- (2011) Hui-Xiong Dai et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Innate C-H trifluoromethylation of heterocycles
- (2011) Y. Ji et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transition-Metal-Catalyzed C-H Functionalization for the Synthesis of Substituted Pyridines
- (2011) Yoshiaki Nakao SYNTHESIS-STUTTGART
- Recombinant human cytochrome P450 monooxygenases for drug metabolite synthesis
- (2010) Kirsten Schroer et al. BIOTECHNOLOGY AND BIOENGINEERING
- Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions
- (2010) Thomas W. Lyons et al. CHEMICAL REVIEWS
- Nucleophilic substitution of hydrogen in electron-deficient arenes, a general process of great practical value
- (2010) Mieczysław Mąkosza CHEMICAL SOCIETY REVIEWS
- On the Mechanism of Palladium-Catalyzed Aromatic C−H Oxidation
- (2010) David C. Powers et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Room-Temperature Regioselective C−H/Olefin Coupling of Aromatic Ketones Using an Activated Ruthenium Catalyst with a Carbonyl Ligand and Structural Elucidation of Key Intermediates
- (2010) Fumitoshi Kakiuchi et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Bimetallic Reductive Elimination from Dinuclear Pd(III) Complexes
- (2010) David C. Powers et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Functionalization of Aromatic Amino Acids via Direct C−H Activation: Generation of Versatile Building Blocks for Accessing Novel Peptide Space
- (2010) Falco-Magnus Meyer et al. ORGANIC LETTERS
- A Panel of Cytochrome P450 BM3 Variants to Produce Drug Metabolites and Diversify Lead Compounds
- (2009) Andrew M. Sawayama et al. CHEMISTRY-A EUROPEAN JOURNAL
- Pd(II)-Catalyzed Hydroxylation of Arenes with 1 atm of O2or Air
- (2009) Yang-Hui Zhang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Synthetic and Mechanistic Studies of Pd-Catalyzed C−H Arylation with Diaryliodonium Salts: Evidence for a Bimetallic High Oxidation State Pd Intermediate
- (2009) Nicholas R. Deprez et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Bimetallic Palladium Catalysis: Direct Observation of Pd(III)−Pd(III) Intermediates
- (2009) David C. Powers et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Synthetic Applications of Pd(II)-Catalyzed C−H Carboxylation and Mechanistic Insights: Expedient Routes to Anthranilic Acids, Oxazolinones, and Quinazolinones
- (2009) Ramesh Giri et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Bimetallic Pd(III) complexes in palladium-catalysed carbon–heteroatom bond formation
- (2009) David C. Powers et al. Nature Chemistry
- Ligand-Enabled Reactivity and Selectivity in a Synthetically Versatile Aryl C-H Olefination
- (2009) D.-H. Wang et al. SCIENCE
- Molecular Imaging with PET
- (2008) Simon M. Ametamey et al. CHEMICAL REVIEWS
- Analysis of the Concerted Metalation-Deprotonation Mechanism in Palladium-Catalyzed Direct Arylation Across a Broad Range of Aromatic Substrates
- (2008) Serge I. Gorelsky et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started