A Diverse Set of Single-domain Antibodies (VHHs) against the Anthrax Toxin Lethal and Edema Factors Provides a Basis for Construction of a Bispecific Agent That Protects against Anthrax Infection

Adenoviral Expression of a Bispecific VHH-Based Neutralizing Agent That Targets Protective Antigen Provides Prophylactic Protection from Anthrax in Mice

(2016) Mahtab Moayeri et al.   Clinical and Vaccine Immunology

Extending the half-life of a fab fragment through generation of a humanized anti-human serum albumin Fv domain: An investigation into the correlation between affinity and serum half-life

(2016) Ralph Adams et al.   mAbs

Anthrax Pathogenesis

(2015) Mahtab Moayeri et al.   Annual Review of Microbiology

Mechanisms of Ricin Toxin Neutralization Revealed through Engineered Homodimeric and Heterodimeric Camelid Antibodies

(2015) Cristina Herrera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Heterodimer of a VHH (Variable Domains of Camelid Heavy Chain-only) Antibody That Inhibits Anthrax Toxin Cell Binding Linked to a VHH Antibody That Blocks Oligomer Formation Is Highly Protective in an Anthrax Spore Challenge Model

(2015) Mahtab Moayeri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenoviral targeting using genetically incorporated camelid single variable domains

(2014) Sergey A Kaliberov et al.   LABORATORY INVESTIGATION

Prolonged Prophylactic Protection from Botulism with a Single Adenovirus Treatment Promoting Serum Expression of a VHH-Based Antitoxin Protein

(2014) Jean Mukherjee et al.   PLoS One

Nanobodies: Natural Single-Domain Antibodies

(2013) Serge Muyldermans   Annual Review of Biochemistry

Small-Molecule Inhibitors of Lethal Factor Protease Activity Protect against Anthrax Infection

(2013) Mahtab Moayeri et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Single VHH-Based Toxin-Neutralizing Agent and an Effector Antibody Protect Mice against Challenge with Shiga Toxins 1 and 2

(2013) Jacqueline M. Tremblay et al.   INFECTION AND IMMUNITY

Stepwise Engineering of Heterodimeric Single Domain Camelid VHH Antibodies That Passively Protect Mice from Ricin Toxin

(2013) David J. Vance et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nanobodies and their potential applications

(2013) Gholamreza Hassanzadeh-Ghassabeh et al.   Nanomedicine

Mapping the Epitopes of a Neutralizing Antibody Fragment Directed against the Lethal Factor of Bacillus anthracis and Cross-Reacting with the Homologous Edema Factor

(2013) Philippe Thullier et al.   PLoS One

A Novel Strategy for Development of Recombinant Antitoxin Therapeutics Tested in a Mouse Botulism Model

(2012) Jean Mukherjee et al.   PLoS One

Idiotypes as immunogens: facing the challenge of inducing strong therapeutic immune responses against the variable region of immunoglobulins

(2012) Alejandro López-Requena et al.   Frontiers in Oncology

Lactobacilli producing bispecific llama-derived anti-rotavirus proteins in vivo for rotavirus-induced diarrhea

(2011) Neha Pant et al.   Future Microbiology

Mouse Monoclonal Antibodies to Anthrax Edema Factor Protect against Infection

(2011) Clinton E. Leysath et al.   INFECTION AND IMMUNITY

Llama-Derived Single Domain Antibodies to Build Multivalent, Superpotent and Broadened Neutralizing Anti-Viral Molecules

(2011) Anna Hultberg et al.   PLoS One

Monoclonal Antibody Therapies against Anthrax

(2011) Zhaochun Chen et al.   Toxins

Anthrax Toxin Targeting of Myeloid Cells through the CMG2 Receptor Is Essential for Establishment of Bacillus anthracis Infections in Mice

(2010) Shihui Liu et al.   Cell Host & Microbe

Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers

(2010) Geoffrey K Feld et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Camelid single domain antibodies (VHHs) as neuronal cell intrabody binding agents and inhibitors of Clostridium botulinum neurotoxin (BoNT) proteases

(2010) Jacqueline M. Tremblay et al.   TOXICON

Novel Chimpanzee/Human Monoclonal Antibodies That Neutralize Anthrax Lethal Factor, and Evidence for Possible Synergy with Anti-Protective Antigen Antibody

(2009) Z. Chen et al.   INFECTION AND IMMUNITY