Mechanisms of Ricin Toxin Neutralization Revealed through Engineered Homodimeric and Heterodimeric Camelid Antibodies

Intra-Spike Crosslinking Overcomes Antibody Evasion by HIV-1

(2015) Rachel P. Galimidi et al.   CELL

A Heterodimer of a VHH (Variable Domains of Camelid Heavy Chain-only) Antibody That Inhibits Anthrax Toxin Cell Binding Linked to a VHH Antibody That Blocks Oligomer Formation Is Highly Protective in an Anthrax Spore Challenge Model

(2015) Mahtab Moayeri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combination of two candidate subunit vaccine antigens elicits protective immunity to ricin and anthrax toxin in mice

(2015) David J. Vance et al.   VACCINE

Heat-Labile Enterotoxin IIa, a Platform To Deliver Heterologous Proteins into Neurons

(2015) Chen Chen et al.   mBio

Selection of Nanobodies that Block the Enzymatic and Cytotoxic Activities of the Binary Clostridium Difficile Toxin CDT

(2015) Mandy Unger et al.   Scientific Reports

Chimeric Plantibody Passively Protects Mice against Aerosolized Ricin Challenge

(2014) Erin K. Sully et al.   Clinical and Vaccine Immunology

Adenovirus Vector Expressing Stx1/Stx2-Neutralizing Agent Protects Piglets Infected with Escherichia coli O157:H7 against Fatal Systemic Intoxication

(2014) Abhineet S. Sheoran et al.   INFECTION AND IMMUNITY

A Novel Multivalent, Single-Domain Antibody Targeting TcdA and TcdB Prevents Fulminant Clostridium difficile Infection in Mice

(2014) Zhiyong Yang et al.   JOURNAL OF INFECTIOUS DISEASES

Crystal Structures of Ricin Toxin's Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-Neutralizing Single-Chain Antibodies

(2014) Michael J. Rudolph et al.   JOURNAL OF MOLECULAR BIOLOGY

Differential Neutralizing Activities of a Single Domain Camelid Antibody (VHH) Specific for Ricin Toxin’s Binding Subunit (RTB)

(2014) Cristina Herrera et al.   PLoS One

Prolonged Prophylactic Protection from Botulism with a Single Adenovirus Treatment Promoting Serum Expression of a VHH-Based Antitoxin Protein

(2014) Jean Mukherjee et al.   PLoS One

A tripartite cocktail of chimeric monoclonal antibodies passively protects mice against ricin, staphylococcal enterotoxin B and Clostridium perfringens epsilon toxin

(2014) Erin K. Sully et al.   TOXICON

Antibody-Mediated Inhibition of Ricin Toxin Retrograde Transport

(2014) A. Yermakova et al.   mBio

Nanobodies: Natural Single-Domain Antibodies

(2013) Serge Muyldermans   Annual Review of Biochemistry

Disease-Enhancing Antibodies Improve the Efficacy of Bacterial Toxin-Neutralizing Antibodies

(2013) Siu-Kei Chow et al.   Cell Host & Microbe

Retrograde transport of protein toxins through the Golgi apparatus

(2013) Kirsten Sandvig et al.   HISTOCHEMISTRY AND CELL BIOLOGY

A Single VHH-Based Toxin-Neutralizing Agent and an Effector Antibody Protect Mice against Challenge with Shiga Toxins 1 and 2

(2013) Jacqueline M. Tremblay et al.   INFECTION AND IMMUNITY

Structural Basis for Antibody Recognition in the Receptor-binding Domains of Toxins A and B fromClostridium difficile

(2013) Tomohiko Murase et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stepwise Engineering of Heterodimeric Single Domain Camelid VHH Antibodies That Passively Protect Mice from Ricin Toxin

(2013) David J. Vance et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Current biodefense vaccine programs and challenges

(2013) Daniel N. Wolfe et al.   Human Vaccines & Immunotherapeutics

Antibodies for biodefense

(2012) Jeffrey W. Froude et al.   mAbs

A Novel Strategy for Development of Recombinant Antitoxin Therapeutics Tested in a Mouse Botulism Model

(2012) Jean Mukherjee et al.   PLoS One

Protective immunity to ricin toxin conferred by antibodies against the toxin's binding subunit (RTB)

(2011) Anastasiya Yermakova et al.   VACCINE

Plant-based expression of a partially humanized neutralizing monoclonal IgG directed against an immunodominant epitope on the ricin toxin A subunit

(2011) Joanne M. O’Hara et al.   VACCINE

Probing the binding mechanism and affinity of tanezumab, a recombinant humanized anti-NGF monoclonal antibody, using a repertoire of biosensors

(2008) Yasmina Noubia Abdiche et al.   PROTEIN SCIENCE