Isoform- and cell-state-specific lipidation of ApoE in astrocytes

ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism

(2021) Guoyuan Qi et al.   Cell Reports

APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia

(2021) Grzegorz Sienski et al.   Science Translational Medicine

An integrative multi-omics approach reveals new central nervous system pathway alterations in Alzheimer’s disease

(2021) Christopher Clark et al.   Alzheimers Research & Therapy

APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes

(2021) Sherida M. de Leeuw et al.   Stem Cell Reports

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

(2020) Julia Marschallinger et al.   NATURE NEUROSCIENCE

Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

(2020) Eric M. Reiman et al.   Nature Communications

Lipid Droplets in Neurodegenerative Disorders

(2020) Brandon C. Farmer et al.   Frontiers in Neuroscience

Corrigendum to “Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line” [Stem Cell Res. 34/1873–5061 (2019) 101349–55]

(2020) Benjamin Schmid et al.   Stem Cell Research

Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line

(2019) Benjamin Schmid et al.   Stem Cell Research

Apolipoprotein E4 Alters Astrocyte Fatty Acid Metabolism and Lipid Droplet Formation

(2019) Brandon Farmer et al.   Cells

Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity

(2019) Maria S. Ioannou et al.   CELL

Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer

(2019) Andrew M. Petros et al.   JOURNAL OF MEDICINAL CHEMISTRY

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

(2019) Yu Yamazaki et al.   Nature Reviews Neurology

ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes

(2019) Varun Rawat et al.   JOURNAL OF NEUROSCIENCE

SR-B1: A Unique Multifunctional Receptor for Cholesterol Influx and Efflux

(2018) Wen-Jun Shen et al.   Annual Review of Physiology

HDL Mimetic Peptide 4F Mitigates Aβ-Induced Inhibition of ApoE Secretion and Lipidation in Primary Astrocytes and Microglia

(2018) Dustin Chernick et al.   JOURNAL OF NEUROCHEMISTRY

PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation

(2018) Seung-Won Choi et al.   MOLECULAR CELL

APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes

(2017) Jing Zhao et al.   HUMAN MOLECULAR GENETICS

Comprehensive analysis of phospholipids in the brain, heart, kidney, and liver: brain phospholipids are least enriched with polyunsaturated fatty acids

(2017) Jaewoo Choi et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

PI(4,5)P2 Is Translocated by ABCA1 to the Cell Surface Where It Mediates Apolipoprotein A1 Binding and Nascent HDL AssemblyNovelty and Significance

(2016) Kailash Gulshan et al.   CIRCULATION RESEARCH

A protocol for the systematic and quantitative measurement of protein–lipid interactions using the liposome-microarray-based assay

(2016) Antoine-Emmanuel Saliba et al.   Nature Protocols

Establishment of human iPSC-based models for the study and targeting of glioma initiating cells

(2016) Ignacio Sancho-Martinez et al.   Nature Communications

Orchestrating high-throughput genomic analysis with Bioconductor

(2015) Wolfgang Huber et al.   NATURE METHODS

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

A quantitative liposome microarray to systematically characterize protein-lipid interactions

(2013) Antoine-Emmanuel Saliba et al.   NATURE METHODS

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions

(2011) J. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanism of Apolipoprotein E Binding to Lipoprotein Particles†

(2009) David Nguyen et al.   BIOCHEMISTRY

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Genetic profiling of human cell lines used as in vitro model to study cardiovascular pathophysiology and pharmacotoxicology

(2008) Elise Jeannesson et al.   CELL BIOLOGY AND TOXICOLOGY

The Effect of T0901317 on ATP-binding Cassette Transporter A1 and Niemann-Pick Type C1 in ApoE???/??? Mice

(2008) Xiao-yan Dai et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Apoprotein E as a lipid transport and signaling protein in the blood, liver, and artery wall

(2008) Godfrey S. Getz et al.   JOURNAL OF LIPID RESEARCH

Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels

(2008) D. R. Riddell et al.   JOURNAL OF NEUROSCIENCE