The 3′ Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies’ association with histone locus bodies

Reconstitution of 3′ end processing of mammalian pre-mRNA reveals a central role of RBBP6

(2022) Moritz Schmidt et al.   GENES & DEVELOPMENT

RBBP6 activates the pre-mRNA 3′ end processing machinery in humans

(2022) Vytaute Boreikaite et al.   GENES & DEVELOPMENT

RNA polymerase II condensate formation and association with Cajal and histone locus bodies in living human cells

(2021) Takashi Imada et al.   GENES TO CELLS

Superresolution light microscopy of the Drosophila histone locus body reveals a core–shell organization associated with expression of replication–dependent histone genes

(2021) James P. Kemp et al.   MOLECULAR BIOLOGY OF THE CELL

The role of Mediator and Little Elongation Complex in transcription termination

(2020) Hidehisa Takahashi et al.   Nature Communications

CDK11 is required for transcription of replication-dependent histone genes

(2020) Pavla Gajdušková et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CDK-Regulated Phase Separation Seeded by Histone Genes Ensures Precise Growth and Function of Histone Locus Bodies

(2020) Woonyung Hur et al.   DEVELOPMENTAL CELL

Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination

(2020) Kai-Lieh Huang et al.   MOLECULAR CELL

Termination of Transcription by RNA Polymerase II: BOOM!

(2020) Joshua D. Eaton et al.   TRENDS IN GENETICS

Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation

(2019) Leighton Core et al.   GENES & DEVELOPMENT

Assembling nuclear domains: Lessons from DNA repair

(2019) Benjamin Schrank et al.   JOURNAL OF CELL BIOLOGY

4C-seq from start to end: a detailed protocol for sample preparation and data analysis

(2019) Peter H.L. Krijger et al.   METHODS

CUT&Tag for efficient epigenomic profiling of small samples and single cells

(2019) Hatice S. Kaya-Okur et al.   Nature Communications

An improved auxin-inducible degron system preserves native protein levels and enables rapid and specific protein depletion

(2019) Kizhakke Mattada Sathyan et al.   GENES & DEVELOPMENT

A unified allosteric/torpedo mechanism for transcriptional termination on human protein-coding genes

(2019) Joshua D. Eaton et al.   GENES & DEVELOPMENT

Control of RNA Pol II Speed by PNUTS-PP1 and Spt5 Dephosphorylation Facilitates Termination by a “Sitting Duck Torpedo” Mechanism

(2019) Michael A. Cortazar et al.   MOLECULAR CELL

Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity

(2018) Joshua D. Eaton et al.   GENES & DEVELOPMENT

Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation

(2018) Tomohiro Yamazaki et al.   MOLECULAR CELL

The Sm-core mediates the retention of partially-assembled spliceosomal snRNPs in Cajal bodies until their full maturation

(2018) Adriana Roithová et al.   NUCLEIC ACIDS RESEARCH

Protein composition of catalytically active U7-dependent processing complexes assembled on histone pre-mRNA containing biotin and a photo-cleavable linker

(2018) Aleksandra Skrajna et al.   NUCLEIC ACIDS RESEARCH

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

Protein Phase Separation: A New Phase in Cell Biology

(2018) Steven Boeynaems et al.   TRENDS IN CELL BIOLOGY

Phase Separation and Transcription Regulation: Are Super-Enhancers and Locus Control Regions Primary Sites of Transcription Complex Assembly?

(2018) Aishwarya Gurumurthy et al.   BIOESSAYS

Membraneless nuclear organelles and the search for phases within phases

(2018) Iain A. Sawyer et al.   Wiley Interdisciplinary Reviews-RNA

Biotinylation by antibody recognition—a method for proximity labeling

(2017) Daniel Z Bar et al.   NATURE METHODS

Transcription regulation by the Mediator complex

(2017) Julie Soutourina   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Coordinating cell cycle-regulated histone gene expression through assembly and function of the Histone Locus Body

(2017) Robert J. Duronio et al.   RNA Biology

The Mediator Complex: At the Nexus of RNA Polymerase II Transcription

(2017) Célia Jeronimo et al.   TRENDS IN CELL BIOLOGY

Regulation of expression of human RNA polymerase II-transcribed snRNA genes

(2017) Joana Guiro et al.   Open Biology

Cajal body function in genome organization and transcriptome diversity

(2016) Iain A. Sawyer et al.   BIOESSAYS

Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers

(2016) Yi Lin et al.   CELL

TBP loading by AF4 through SL1 is the major rate-limiting step in MLL fusion-dependent transcription

(2016) Hiroshi Okuda et al.   CELL CYCLE

Cycling in the nucleus: regulation of RNA 3′ processing and nuclear organization of replication-dependent histone genes

(2016) Valentina Romeo et al.   CURRENT OPINION IN CELL BIOLOGY

Concentrating pre-mRNA processing factors in the histone locus body facilitates efficient histone mRNA biogenesis

(2016) Deirdre C. Tatomer et al.   JOURNAL OF CELL BIOLOGY

Eukaryotic Transcription Regulation: Getting to the Heart of the Matter: Commentary on Mediator Architecture and RNA Polymerase II Function by Plaschka et al

(2016) Sohail Malik   JOURNAL OF MOLECULAR BIOLOGY

Base-pair-resolution genome-wide mapping of active RNA polymerases using precision nuclear run-on (PRO-seq)

(2016) Dig Bijay Mahat et al.   Nature Protocols

YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression

(2016) Shawn M. Lyons et al.   NUCLEIC ACIDS RESEARCH

Cajal bodies and snRNPs - friends with benefits

(2016) David Staněk   RNA Biology

Specific genomic cues regulate Cajal body assembly

(2016) Iain A. Sawyer et al.   RNA Biology

TUT7 catalyzes the uridylation of the 3′ end for rapid degradation of histone mRNA

(2016) Patrick E. Lackey et al.   RNA

Cajal bodies are linked to genome conformation

(2016) Qiuyan Wang et al.   Nature Communications

The Mediator complex: a central integrator of transcription

(2015) Benjamin L. Allen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Getting up to speed with transcription elongation by RNA polymerase II

(2015) Iris Jonkers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Coilin: The first 25 years

(2015) Martin Machyna et al.   RNA Biology

EnD-Seq and AppEnD: sequencing 3′ ends to identify nontemplated tails and degradation intermediates

(2015) Joshua D. Welch et al.   RNA

MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex

(2015) Hidehisa Takahashi et al.   Nature Communications

FLASH and NPAT positive but not Coilin positive Cajal bodies correlate with cell ploidy

(2014) Lucilla Bongiorno-Borbone et al.   CELL CYCLE

Regulation of RNA Polymerase II Termination by Phosphorylation of Gdown1

(2014) Jiannan Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CstF64: Cell Cycle Regulation and Functional Role in 3' End Processing of Replication-Dependent Histone mRNAs

(2014) V. Romeo et al.   MOLECULAR AND CELLULAR BIOLOGY

The Coilin Interactome Identifies Hundreds of Small Noncoding RNAs that Traffic through Cajal Bodies

(2014) Martin Machyna et al.   MOLECULAR CELL

DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes

(2014) Junichi Yamamoto et al.   Nature Communications

CBC–ARS2 stimulates 3′-end maturation of multiple RNA families and favors cap-proximal processing

(2013) Marie Hallais et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Mediator complex and transcription elongation

(2012) Ronald C. Conaway et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The integrator complex is required for integrity of Cajal bodies

(2012) H. Takata et al.   JOURNAL OF CELL SCIENCE

snRNA 3' End Formation Requires Heterodimeric Association of Integrator Subunits

(2012) T. R. Albrecht et al.   MOLECULAR AND CELLULAR BIOLOGY

A Complex Containing the CPSF73 Endonuclease and Other Polyadenylation Factors Associates with U7 snRNP and Is Recruited to Histone Pre-mRNA for 3'-End Processing

(2012) X.-C. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

RNA Polymerase II Pausing Downstream of Core Histone Genes Is Different from Genes Producing Polyadenylated Transcripts

(2012) Krishanpal Anamika et al.   PLoS One

Cajal bodies: where form meets function

(2012) Martin Machyna et al.   Wiley Interdisciplinary Reviews-RNA

Human Mediator Subunit MED26 Functions as a Docking Site for Transcription Elongation Factors

(2011) Hidehisa Takahashi et al.   CELL

Drosophilahistone locus bodies form by hierarchical recruitment of components

(2011) Anne E. White et al.   JOURNAL OF CELL BIOLOGY

snRNA 3′ end formation: the dawn of the Integrator complex

(2010) Jiandong Chen et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Cajal Body and Histone Locus Body

(2010) Z. Nizami et al.   Cold Spring Harbor Perspectives in Biology

WRAP53 Is Essential for Cajal Body Formation and for Targeting the Survival of Motor Neuron Complex to Cajal Bodies

(2010) Salah Mahmoudi et al.   PLOS BIOLOGY

Transcription termination by nuclear RNA polymerases

(2009) P. Richard et al.   GENES & DEVELOPMENT

Coilin Is Essential for Cajal Body Organization in Drosophila melanogaster

(2009) Ji-Long Liu et al.   MOLECULAR BIOLOGY OF THE CELL

A Conserved WD40 Protein Binds the Cajal Body Localization Signal of scaRNP Particles

(2009) Kazimierz T. Tycowski et al.   MOLECULAR CELL

The RNA Polymerase II Trigger Loop Functions in Substrate Selection and Is Directly Targeted by α-Amanitin

(2008) Craig D. Kaplan et al.   MOLECULAR CELL