RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype
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Title
RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype
Authors
Keywords
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Journal
Nature Communications
Volume 10, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-10-11
DOI
10.1038/s41467-019-12529-3
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Note: Only part of the references are listed.- Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγ Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer
- (2019) Yan Zhang et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2018) Bo Wang et al. Nature Reviews Endocrinology
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- (2018) Dabin Liu et al. Science Translational Medicine
- Insensitivity to atorvastatin is associated with increased accumulation of intracellular lipid droplets and fatty acid metabolism in breast cancer cells
- (2018) Barbara Lettiero et al. Scientific Reports
- The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery
- (2018) Yun Xia et al. CELL
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- (2018) Natalia Mast et al. DRUG METABOLISM AND DISPOSITION
- Molecular alterations in triple-negative breast cancer—the road to new treatment strategies
- (2017) Carsten Denkert et al. LANCET
- Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor
- (2017) Maud Voisin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells
- (2017) Amy E. Baek et al. Nature Communications
- An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers
- (2016) Genaro R. Villa et al. CANCER CELL
- Statins increase hepatic cholesterol synthesis and stimulate fecal cholesterol elimination in mice
- (2016) Marleen Schonewille et al. JOURNAL OF LIPID RESEARCH
- Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer
- (2016) Roman Camarda et al. NATURE MEDICINE
- ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer
- (2016) Junjian Wang et al. NATURE MEDICINE
- ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer
- (2016) Geneviève Deblois et al. Nature Communications
- Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions
- (2016) C. Vernieri et al. Cancer Discovery
- Intratumor cholesteryl ester accumulation is associated with human breast cancer proliferation and aggressive potential: a molecular and clinicopathological study
- (2015) David de Gonzalo-Calvo et al. BMC CANCER
- Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress
- (2015) Zachary T. Schug et al. CANCER CELL
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- (2015) Luciana Benevides et al. CANCER RESEARCH
- A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins
- (2015) Joseph L. Goldstein et al. CELL
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- (2015) Fabio R. Santori et al. Cell Metabolism
- Global Transcriptional Changes Following Statin Treatment in Breast Cancer
- (2015) O. Bjarnadottir et al. CLINICAL CANCER RESEARCH
- IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis
- (2015) Seth B. Coffelt et al. NATURE
- Sterol metabolism controls T H 17 differentiation by generating endogenous RORγ agonists
- (2015) Xiao Hu et al. Nature Chemical Biology
- Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion
- (2015) Van T. M. Nguyen et al. Nature Communications
- Immediate Utility of Two Approved Agents to Target Both the Metabolic Mevalonate Pathway and Its Restorative Feedback Loop
- (2014) Aleksandra Pandyra et al. CANCER RESEARCH
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- (2014) Shuhua Yue et al. Cell Metabolism
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- (2014) Sheng Xiao et al. IMMUNITY
- Statins and breast cancer prognosis: evidence and opportunities
- (2014) Thomas P Ahern et al. LANCET ONCOLOGY
- Fatostatin Displays High Antitumor Activity in Prostate Cancer by Blocking SREBP-Regulated Metabolic Pathways and Androgen Receptor Signaling
- (2014) X. Li et al. MOLECULAR CANCER THERAPEUTICS
- REV-ERB and ROR nuclear receptors as drug targets
- (2014) Douglas J. Kojetin et al. NATURE REVIEWS DRUG DISCOVERY
- Oxysterols are agonist ligands of ROR t and drive Th17 cell differentiation
- (2014) P. Soroosh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Retinoic Acid-Related Orphan Receptor γ (RORγ): A Novel Participant in the Diurnal Regulation of Hepatic Gluconeogenesis and Insulin Sensitivity
- (2014) Yukimasa Takeda et al. PLoS Genetics
- Targeting HMG-CoA reductase with statins in a window-of-opportunity breast cancer trial
- (2013) Olöf Bjarnadottir et al. BREAST CANCER RESEARCH AND TREATMENT
- Interleukin-17-producing cell infiltration in the breast cancer tumour microenvironment is a poor prognostic factor
- (2013) Wen-Chung Chen et al. HISTOPATHOLOGY
- Comparative metabolomics of estrogen receptor positive and estrogen receptor negative breast cancer: alterations in glutamine and beta-alanine metabolism
- (2013) Jan Budczies et al. Journal of Proteomics
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- (2013) E. R. Nelson et al. SCIENCE
- COMPADRE: an R and web resource for pathway activity analysis by component decompositions
- (2012) Roberto-Rafael Ramos-Rodriguez et al. BIOINFORMATICS
- Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue – a GC-TOFMS based metabolomics study
- (2012) Jan Budczies et al. BMC GENOMICS
- Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway
- (2012) William A. Freed-Pastor et al. CELL
- Targeting tumor cell metabolism with statins
- (2012) J W Clendening et al. ONCOGENE
- The volatile compound BinBase mass spectral database
- (2011) Kirsten Skogerson et al. BMC BIOINFORMATICS
- TGF- Receptor II Loss Promotes Mammary Carcinoma Progression by Th17-Dependent Mechanisms
- (2011) S. V. Novitskiy et al. Cancer Discovery
- Dysregulation of the mevalonate pathway promotes transformation
- (2010) J. W. Clendening et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- FiehnLib: Mass Spectral and Retention Index Libraries for Metabolomics Based on Quadrupole and Time-of-Flight Gas Chromatography/Mass Spectrometry
- (2009) Tobias Kind et al. ANALYTICAL CHEMISTRY
- ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks
- (2009) Gabriela Bindea et al. BIOINFORMATICS
- Fast and accurate short read alignment with Burrows-Wheeler transform
- (2009) H. Li et al. BIOINFORMATICS
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