Article
Oncology
Yingfang Fan, Tian Tao, Zhixing Guo, Kenneth Kin Wah To, Da Chen, Shaocong Wu, Chuan Yang, Jinsui Li, Min Luo, Fang Wang, Liwu Fu
Summary: The study demonstrates that lazertinib effectively reverses MDR by inhibiting drug efflux activities of ABCB1 and ABCG2, leading to increased intracellular accumulation of transporter substrate anticancer drugs. Additionally, lazertinib competitively binds to the ATP-binding site of the transporters and stimulates their ATPase activity, showing potential for overcoming MDR in cancer cells overexpressing ABCB1/ABCG2.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Article
Biochemistry & Molecular Biology
Costanza E. Maurici, Robin Colenbier, Britta Wylleman, Luigi Brancato, Eke van Zwol, Johan Van den Bossche, Jean-Pierre Timmermans, Elisa Giovannetti, Marina G. M. C. Mori da Cunha, Johannes Bogers
Summary: The study found that hyperthermia not only directly inhibits the proliferation of PDAC cells, but also enhances the effectiveness of chemotherapy drugs, which has a positive impact on the treatment of PDAC patients.
Article
Pharmacology & Pharmacy
Changlu Li, Chunling Zhang, Yanfei Wang, Alaa Yousef Ghidan, Ranganathan Babujanarthanam
Summary: The study demonstrates that the combination of nobiletin and docetaxel enhances apoptosis in colorectal cancer cells by inhibiting PI3K/AKT phosphorylation and regulating the expression of apoptosis-related genes, offering potential for nobiletin in chemosensitization of HCT-116.
LATIN AMERICAN JOURNAL OF PHARMACY
(2021)
Article
Biochemistry & Molecular Biology
Dhanamjai Penta, Priya Mondal, Jagadish Natesh, Syed Musthapa Meeran
Summary: The study demonstrates that diindolylmethane can enhance the efficacy of Centchroman in treating breast cancer by modulating drug efflux transporters, inhibiting cell proliferation, inducing apoptosis, and hindering stemness of cancer cells.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Chung-Pu Wu, Tai-Ho Hung, Sabrina Lusvarghi, Yi-Hsuan Chu, Sung-Han Hsiao, Yang-Hui Huang, Yu-Tzu Chang, Suresh V. Ambudkar
Summary: The study found that Almonertinib can inhibit the drug transport activity of ABCBl at submicromolar concentrations, but not affect ABCG2, and resensitize multidrug-resistant cancer cells overexpressing ABCB1 to chemotherapeutic drugs.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xing-Duo Dong, Meng Zhang, Chao-Yun Cai, Qiu-Xu Teng, Jing-Quan Wang, Yi-Ge Fu, Qingbin Cui, Ketankumar Patel, Dong-Tao Wang, Zhe-Sheng Chen
Summary: This study investigated the potential drug resistance mechanism of the KRAS-G12C inhibitor ARS-1620 associated with ABCB1. The findings indicated that ARS-1620 could be competitively pumped out by ABCB1 in cancer cells and significantly stimulated the ATPase activity of ABCB1. These findings suggest that the potential influence of ARS-1620-related cancer therapy on ABCB1-overexpressing cancer cells should be considered in future clinical applications.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Eunju Kim, Yoon-Jin Kim, Zhiwei Ji, Jin Muk Kang, Marvin Wirianto, Keshav Raj Paudel, Joshua A. Smith, Kaori Ono, Jin-Ah Kim, Kristin Eckel-Mahan, Xiaobo Zhou, Hyun Kyoung Lee, Ji Young Yoo, Seung-Hee Yoo, Zheng Chen
Summary: This study identified the anti-TNBC mechanism of ROR-NOB through suppression of NF-kappa B signaling, suggesting novel preventive and chemotherapeutic strategies against this devastating disease.
CELL DEATH & DISEASE
(2022)
Article
Pharmacology & Pharmacy
C. Li, Chunling Zhang, Yanfei Wang, Alaa Yousef Ghidan, T. M. Antary
Summary: Nobiletin, derived from citrus peel, has shown various pharmacological roles, including anti-inflammatory, anti-tumor, and neuroprotective properties. This study found that combining nobiletin with docetaxel enhances apoptosis in colorectal cancer cells by increasing reactive oxygen species generation, damaging mitochondrial membrane potential, and upregulating pro-apoptotic gene expression.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Maria Ovejero-Sanchez, Gloria Asensio-Juarez, Myriam Gonzalez, Pilar Puebla, Miguel Vicente-Manzanares, Rafael Pelaez, Rogelio Gonzalez-Sarmiento, Ana Belen Herrero
Summary: This study synthesized and characterized a new microtubule-destabilizing agent, PILA9, which showed strong cytotoxicity against OC cells. Additionally, the combination of microtubule-destabilizing agents with Panobinostat synergistically enhanced cytotoxicity, potentially through inducing alpha-tubulin acetylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Wenbin Xu, Shangdan Xie, Xin Chen, Shuya Pan, Hongfei Qian, Xueqiong Zhu
Summary: This study demonstrated that quercetin has inhibitory effects on cervical cancer cells and acts synergistically with cisplatin, enhancing the antitumor effect of cisplatin by inhibiting proliferation, migration, and invasion, and promoting apoptosis through downregulating MMP2, ezrin, METTL3, and P-Gp expression.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Letter
Chemistry, Medicinal
Alberto Boretti
Summary: Quercetin has a wide range of potential health benefits as it can act as a supplement or treatment for various conditions. It possesses antioxidant and anti-inflammatory properties, making it a potential cancer chemopreventive and chemotherapeutic agent that can kill cancer cells and possess senolytic properties. While clinical trials are needed for specific drug uses, it can be used as a general chemo-preventive supplement without contraindications.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Chung-Pu Wu, Cheng-Yu Hung, Sabrina Lusvarghi, Yen-Fu Chang, Sung-Han Hsiao, Yang-Hui Huang, Tai-Ho Hung, Jau-Song Yu, Suresh. V. Ambudkar
Summary: The study revealed that the multidrug efflux transporters ABCB1 and ABCG2 play a crucial role in reducing the sensitivity of human cancer cells to citarinostat by decreasing its activity against HDAC6 and intracellular accumulation of the drug. Co-administration of citarinostat with inhibitors of ABCB1 and ABCG2 may optimize its therapeutic application in the clinic.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Changfu Liu, Wenge Xing, Haipeng Yu, Weihao Zhang, Tongguo Si
Summary: The findings suggest that overexpression of ABCB1 and ABCG2 may restrict the efficacy of Gedatolisib in colorectal cancer cells, while co-administration with ABC transporter inhibitors may improve the potency of Gedatolisib.
CANCER CELL INTERNATIONAL
(2021)
Article
Biotechnology & Applied Microbiology
Yun Qu, Zachary S. Dunn, Xianhui Chen, Melanie MacMullan, Gunce Cinay, Hsuan-yao Wang, Jiangyue Liu, Fangheng Hu, Pin Wang
Summary: CAR T cell therapy has shown unprecedented benefits in certain leukemias and lymphomas, but faces challenges in solid tumors. The overexpression of ADA, with modifications such as albumin-binding or collagen-binding domains, enhances CAR T cell efficacy and resistance to exhaustion. These genetic modifications have the potential to improve the therapeutic potential of CAR T cells in solid tumor treatment.
HUMAN GENE THERAPY
(2022)
Article
Pharmacology & Pharmacy
Shengping Ji, Yuqian Ma, Xiaoyan Xing, Binbin Ge, Yutian Li, Xinyue Xu, Jiliang Song, Mei Xiao, Feng Gao, Wenyan Jiang, Chunyan Fang, Xuejian Wang
Summary: The study revealed that overexpression of CD13 leads to multidrug resistance in hepatocellular carcinoma, and the CD13 inhibitor ubenimex can reverse this effect, showing potential as a treatment strategy in combination with chemotherapy agents.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Yantao Li, Jiajun Huang, Wanjun Lin, Zhongwen Yuan, Senling Feng, Ying Xie, Wenzhe Ma
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2016)
Article
Pharmacology & Pharmacy
Sen-Ling Feng, Zhong-Wen Yuan, Xiao-Jun Yao, Wen-Zhe Ma, Liang Liu, Zhong-Qiu Liu, Ying Xie
PHARMACOLOGICAL RESEARCH
(2016)
Article
Pharmacology & Pharmacy
Wanjun Lin, Jiajun Huang, Xiaolin Liao, Zhongwen Yuan, Senling Feng, Ying Xie, Wenzhe Ma
PHARMACOLOGICAL RESEARCH
(2016)
Article
Pharmacology & Pharmacy
Zhong-Wen Yuan, Ya-Zhuo Li, Zhong-Qiu Liu, Sen-ling Feng, Hua Zhou, Chang-Xiao Liu, Liang Liu, Ying Xie
PHARMACOLOGICAL RESEARCH
(2018)
Article
Multidisciplinary Sciences
Wanjun Lin, Jiajun Huang, Zhongwen Yuan, Senling Feng, Ying Xie, Wenzhe Ma
SCIENTIFIC REPORTS
(2017)
Article
Plant Sciences
Sen-Ling Feng, Hai-Bin Luo, Liang Cai, Jie Zhang, Dan Wang, Ying-Jiang Chen, Huan-Xing Zhan, Zhi-Hong Jiang, Ying Xie
JOURNAL OF GINSENG RESEARCH
(2020)
Article
Pharmacology & Pharmacy
Senling Feng, Huifang Zhou, Deyan Wu, Dechong Zheng, Biao Qu, Ruiming Liu, Chen Zhang, Zhe Li, Ying Xie, Hai-Bin Luo
ACTA PHARMACEUTICA SINICA B
(2020)
Article
Plant Sciences
Feng Sen-Ling, Tian Yun, Huo Shuai, Qu Biao, Liu Rui-Ming, Xu Peng, Li Ya-Zhuo, Xie Ying
Article
Plant Sciences
Rui-Ming Liu, Peng Xu, Qi Chen, Sen-ling Feng, Ying Xie
Article
Plant Sciences
Ying Xie, Sen-Ling Feng, Chu-Tian Mai, Yan-Fang Zheng, Hui Wang, Zhong-Qiu Liu, Hua Zhou, Liang Liu
Summary: The study demonstrates that silybin can ameliorate dyslipidemia and arthritis in AIA rats through modulating lipid metabolism and suppressing the up-regulated LXR alpha, highlighting the potential of LXR alpha inhibition as a therapeutic target for rheumatoid arthritis.
Article
Plant Sciences
Ying Xie, Chu-Tian Mai, De-Chong Zheng, Yu-Fei He, Sen-Lin Feng, Ya-Zhou Li, Chang-Xiao Liu, Hua Zhou, Liang Liu
Summary: The study revealed the synergistic anti-arthritic effects of the five herbs in WTD, with Radix Aconite (AC) as the principal anti-inflammatory component. Assistant herbs Herba Ephedrae (EP) and Radix Astragali (AS) intensified the anti-arthritic effects of AC by regulating NF-kappa B and Nrf2 pathways. WTD achieved the best effects in alleviating the symptoms of rheumatoid arthritis through these pathways.
Article
Pharmacology & Pharmacy
Senling Feng, Yuting Li, Hanhui Huang, Hongliang Huang, Yingying Duan, Zhongwen Yuan, Wenting Zhu, Zhengrong Mei, Lianxiang Luo, Pengke Yan
Summary: Cisplatin is an effective chemotherapy drug, but drug resistance is a clinical concern. This study found that isoorientin can reverse drug resistance in lung cancer by promoting ferroptosis through the SIRT6/Nrf2/GPX4 signaling pathway, providing a theoretical basis for its potential clinical application.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Sen Ling Feng, Jing Zhang, Hongliu Jin, Wen Ting Zhu, Zhongwen Yuan
Summary: This network pharmacology study identified quercetin, kaempferol, and tetramethoxyluteolin as the main active compounds in Hypericum japonicum, which showed potential in promoting recovery from cholestatic hepatitis. Key targets associated with the effects included PTGS2, BCL2, CYP7A1, and FXR genes.
MEDICAL SCIENCE MONITOR
(2021)