Mycobacterium tuberculosis PPE51 Inhibits Autophagy by Suppressing Toll-Like Receptor 2-Dependent Signaling

Targeting Autophagy as a Strategy for Developing New Vaccines and Host-Directed Therapeutics Against Mycobacteria

(2021) Emily J. Strong et al.   Frontiers in Microbiology

Mycobacterium tuberculosis RipA Dampens TLR4-Mediated Host Protective Response Using a Multi-Pronged Approach Involving Autophagy, Apoptosis, Metabolic Repurposing, and Immune Modulation

(2021) Mohd Shariq et al.   Frontiers in Immunology

M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival

(2021) Pupu Ge et al.   Autophagy

Mycobacterium tuberculosis Protein PE6 (Rv0335c), a Novel TLR4 Agonist, Evokes an Inflammatory Response and Modulates the Cell Death Pathways in Macrophages to Enhance Intracellular Survival

(2021) Neha Sharma et al.   Frontiers in Immunology

Mycobacterium tuberculosis PE_PGRS20 and PE_PGRS47 Proteins Inhibit Autophagy by Interaction with Rab1A

(2021) Emily J. Strong et al.   mSphere

PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis

(2020) Qinglan Wang et al.   SCIENCE

PPE51 Is Involved in the Uptake of Disaccharides by Mycobacterium tuberculosis

(2020) Małgorzata Korycka-Machała et al.   Cells

Identification of autophagy inhibiting factors of Mycobacterium tuberculosis by high throughput loss of function screening

(2020) Emily J Strong et al.   INFECTION AND IMMUNITY

A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy

(2019) Qiyao Chai et al.   Nature Communications

An autophagy-inducing and TLR-2 activating BCG vaccine induces a robust protection against tuberculosis in mice

(2019) Arshad Khan et al.   npj Vaccines

Therapeutic host-directed strategies to improve outcome in tuberculosis

(2019) C. Young et al.   Mucosal Immunology

Autophagy and Macrophage Functions: Inflammatory Response and Phagocytosis

(2019) Ming-Yue Wu et al.   Cells

Host Directed Therapies for Tuberculosis: Futures Strategies for an Ancient Disease

(2018) Ivana Palucci et al.   CHEMOTHERAPY

Identification and Evaluation of Novel Protective Antigens for the Development of a Candidate Tuberculosis Subunit Vaccine

(2018) Elena Stylianou et al.   INFECTION AND IMMUNITY

Mycobacterium tuberculosis acyl carrier protein inhibits macrophage apoptotic death by modulating the reactive oxygen species/c-Jun N-terminal kinase pathway

(2018) Seungwha Paik et al.   MICROBES AND INFECTION

Genetic and metabolic regulation of Mycobacterium tuberculosis acid growth arrest

(2018) Jacob J. Baker et al.   Scientific Reports

Mycobacterium tuberculosis PPE44 (Rv2770c) is involved in response to multiple stresses and promotes the macrophage expression of IL-12 p40 and IL-6 via the p38, ERK, and NF-κB signaling axis

(2017) Zhaoxiao Yu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mycobacterium tuberculosisis protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA

(2017) Stefan Köster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive definition of human immunodominant CD8 antigens in tuberculosis

(2017) Deborah A. Lewinsohn et al.   npj Vaccines

Mycobacterium tuberculosis PE_PGRS41 Enhances the Intracellular Survival of M. smegmatis within Macrophages Via Blocking Innate Immunity and Inhibition of Host Defense

(2017) Wanyan Deng et al.   Scientific Reports

iLIR database: A web resource for LIR motif-containing proteins in eukaryotes

(2016) Anne-Claire Jacomin et al.   Autophagy

Mycobacterium tuberculosis EIS gene inhibits macrophage autophagy through up-regulation of IL-10 by increasing the acetylation of histone H3

(2016) Liang Duan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis

(2016) Hongjie Pan et al.   BMC BIOCHEMISTRY

A unique PE_PGRS protein inhibiting host cell cytosolic defenses and sustaining full virulence ofMycobacterium marinumin multiple hosts

(2016) Vipul K. Singh et al.   CELLULAR MICROBIOLOGY

Mycobacterium tuberculosis EspB protein suppresses interferon-γ-induced autophagy in murine macrophages

(2016) DanDan Huang et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Preparation and Preclinical Evaluation of Inhalable Particles Containing Rapamycin and Anti-Tuberculosis Agents for Induction of Autophagy

(2016) Anuradha Gupta et al.   PHARMACEUTICAL RESEARCH

Recombinant Lipoprotein Rv1016c Derived from Mycobacterium tuberculosis Is a TLR-2 Ligand that Induces Macrophages Apoptosis and Inhibits MHC II Antigen Processing

(2016) Haibo Su et al.   Frontiers in Cellular and Infection Microbiology

Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47

(2016) Neeraj K. Saini et al.   Nature Microbiology

PE_PGRS33 Contributes to Mycobacterium tuberculosis Entry in Macrophages through Interaction with TLR2

(2016) Ivana Palucci et al.   PLoS One

The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

(2015) Robert O. Watson et al.   Cell Host & Microbe

Sensing ofMycobacterium tuberculosisand consequences to both host and bacillus

(2015) Chelsea E. Stamm et al.   IMMUNOLOGICAL REVIEWS

PPE57 induces activation of macrophages and drives Th1-type immune responses through TLR2

(2015) Ying Xu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Autophagy is not the answer

(2015) Samuel M. Behar et al.   NATURE

Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection

(2015) Jacqueline M. Kimmey et al.   NATURE

PPE26 induces TLR2-dependent activation of macrophages and drives Th1-type T-cell immunity by triggering the cross-talk of multiple pathways involved in the host response

(2015) Haibo Su et al.   Oncotarget

Reactive oxygen species and mitochondria: A nexus of cellular homeostasis

(2015) Joe Dan Dunn et al.   Redox Biology

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

(2014) Daniel J. Klionsky et al.   Autophagy

Compensatory activation of ERK1/2 inAtg5-deficient mouse embryo fibroblasts suppresses oxidative stress-induced cell death

(2014) Jong-Ok Pyo et al.   Autophagy

Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages

(2014) Alfred J Zullo et al.   BMC BIOCHEMISTRY

TLR2 engagement on CD4+T cells enhances effector functions and protective responses toMycobacterium tuberculosis

(2014) Scott M. Reba et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Slow growth ofMycobacterium tuberculosisat acidic pH is regulated byphoPRand host-associated carbon sources

(2014) Jacob J. Baker et al.   MOLECULAR MICROBIOLOGY

Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway

(2012) Robert O. Watson et al.   CELL

Mycobacterial Induction of Autophagy Varies by Species and Occurs Independently of Mammalian Target of Rapamycin Inhibition

(2012) Alfred J. Zullo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation

(2012) E. F. Castillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo

(2011) Kristen L. Meerbrey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-apoptosis and cell survival: A review

(2010) Liam Portt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors

(2010) Clifford V. Harding et al.   NATURE REVIEWS MICROBIOLOGY

Mycobacterium tuberculosis Eis Regulates Autophagy, Inflammation, and Cell Death through Redox-dependent Signaling

(2010) Dong-Min Shin et al.   PLoS Pathogens

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PPE18 of Mycobacterium tuberculosis Interacts with TLR2 and Activates IL-10 Induction in Macrophage

(2009) S. Nair et al.   JOURNAL OF IMMUNOLOGY

Mycobacterial PE, PPE and ESX clusters: novel insights into the secretion of these most unusual protein families

(2009) Daria Bottai et al.   MOLECULAR MICROBIOLOGY

Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells

(2009) Chinnaswamy Jagannath et al.   NATURE MEDICINE