Mycobacterium tuberculosis Protein PE6 (Rv0335c), a Novel TLR4 Agonist, Evokes an Inflammatory Response and Modulates the Cell Death Pathways in Macrophages to Enhance Intracellular Survival

Global Tuberculosis Report 2020 – Reflections on the Global TB burden, treatment and prevention efforts

(2021) Jeremiah Chakaya et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Teleological cooption of Mycobacterium tuberculosis PE/PPE proteins as porins: Role in molecular immigration and emigration

(2021) Aquib Ehtram et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Mycobacterium tuberculosis RipA Dampens TLR4-Mediated Host Protective Response Using a Multi-Pronged Approach Involving Autophagy, Apoptosis, Metabolic Repurposing, and Immune Modulation

(2021) Mohd Shariq et al.   Frontiers in Immunology

Revisiting BCG to control tuberculosis: mucosal delivery and delipidation?

(2020) Javaid Ahmad Sheikh et al.   LANCET INFECTIOUS DISEASES

PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis

(2020) Qinglan Wang et al.   SCIENCE

Comprehensive analysis of iron utilization by Mycobacterium tuberculosis

(2020) Lei Zhang et al.   PLoS Pathogens

Programmatic versus personalised approaches to managing the global epidemic of multidrug-resistant tuberculosis

(2020) Jeremiah Muhwa Chakaya et al.   Lancet Respiratory Medicine

Protein promiscuity in drug discovery, drug-repurposing and antibiotic resistance

(2020) Munishwar N. Gupta et al.   BIOCHIMIE

Intrinsic disorder in proteins: Relevance to protein assemblies, drug design and host-pathogen interactions

(2020) Tom L. Blundell et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Performance and Its Limits in Rigid Body Protein-Protein Docking

(2020) Israel T. Desta et al.   STRUCTURE

Immunodominant Mycobacterium tuberculosis Protein Rv1507A Elicits Th1 Response and Modulates Host Macrophage Effector Functions

(2020) Simran Kaur Arora et al.   Frontiers in Immunology

Identification of immunogenic T-cell peptides of Mycobacterium tuberculosis PE_PGRS33 protein

(2020) David Ortega-Tirado et al.   MOLECULAR IMMUNOLOGY

Mycobacterium smegmatis Bacteria Expressing Mycobacterium tuberculosis-Specific Rv1954A Induce Macrophage Activation and Modulate the Immune Response

(2020) Simran Kaur Arora et al.   Frontiers in Cellular and Infection Microbiology

Post translational modifications in tuberculosis: ubiquitination paradox

(2020) Mohd Shariq et al.   Autophagy

Disorder‐to‐order transition in PE–PPE proteins of Mycobacterium tuberculosis augments the pro‐pathogen immune response

(2019) Javeed Ahmad et al.   FEBS Open Bio

Contrasting Function of Structured N-Terminal and Unstructured C-Terminal Segments of Mycobacterium tuberculosis PPE37 Protein

(2018) Javeed Ahmad et al.   mBio

The PGRS Domain of Mycobacterium tuberculosis PE_PGRS Protein Rv0297 Is Involved in Endoplasmic Reticulum Stress-Mediated Apoptosis through Toll-Like Receptor 4

(2018) Sonam Grover et al.   mBio

Mycobacterium tuberculosis PPE44 (Rv2770c) is involved in response to multiple stresses and promotes the macrophage expression of IL-12 p40 and IL-6 via the p38, ERK, and NF-κB signaling axis

(2017) Zhaoxiao Yu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Structural basis of the PE–PPE protein interaction inMycobacterium tuberculosis

(2017) Xin Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ClusPro web server for protein–protein docking

(2017) Dima Kozakov et al.   Nature Protocols

PPE Surface Proteins Are Required for Heme Utilization by Mycobacterium tuberculosis

(2017) Avishek Mitra et al.   mBio

The PPE2 protein of Mycobacterium tuberculosis translocates to host nucleus and inhibits nitric oxide production

(2017) Khalid Hussain Bhat et al.   Scientific Reports

New findings of Toll-like receptors involved in Mycobacterium tuberculosis infection

(2017) Majid Faridgohar et al.   Pathogens and Global Health

Mycobacterium tuberculosis PE27 activates dendritic cells and contributes to Th1-polarized memory immune responses during in vivo infection

(2016) Woo Sik Kim et al.   IMMUNOBIOLOGY

Bacterial Pathogens versus Autophagy: Implications for Therapeutic Interventions

(2016) Jacqueline M. Kimmey et al.   TRENDS IN MOLECULAR MEDICINE

Mycobacterium tuberculosis Co-operonic PE32/PPE65 Proteins Alter Host Immune Responses by Hampering Th1 Response

(2016) Mohd Khubaib et al.   Frontiers in Microbiology

Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47

(2016) Neeraj K. Saini et al.   Nature Microbiology

PE11, a PE/PPE family protein of Mycobacterium tuberculosis is involved in cell wall remodeling and virulence

(2016) Parul Singh et al.   Scientific Reports

TheMycobacterium tuberculosisprotein pair PE9 (Rv1088)-PE10 (Rv1089) forms heterodimers and induces macrophage apoptosis through Toll-like receptor 4

(2015) Bhavana Tiwari et al.   CELLULAR MICROBIOLOGY

Mycobacterium tuberculosis Resists Stress by Regulating PE19 Expression

(2015) Pavithra Ramakrishnan et al.   INFECTION AND IMMUNITY

NPDock: a web server for protein–nucleic acid docking

(2015) Irina Tuszynska et al.   NUCLEIC ACIDS RESEARCH

An overview to understand the role of PE_PGRS family proteins inMycobacterium tuberculosisH37Rv and their potential as new drug targets

(2014) Laxman S. Meena   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Comparative Analyses of Nonpathogenic, Opportunistic, and Totally Pathogenic Mycobacteria Reveal Genomic and Biochemical Variabilities and Highlight the Survival Attributes of Mycobacterium tuberculosis

(2014) Syed Asad Rahman et al.   mBio

Mycobacterium tuberculosis PE25/PPE41 protein complex induces necrosis in macrophages: Role in virulence and disease reactivation?

(2014) Smanla Tundup et al.   FEBS Open Bio

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

The ULK1 complex

(2013) Pui-Mun Wong et al.   Autophagy

The ESX-3 Secretion System Is Necessary for Iron and Zinc Homeostasis in Mycobacterium tuberculosis

(2013) Agnese Serafini et al.   PLoS One

ESX-1 dependent impairment of autophagic flux byMycobacterium tuberculosisin human dendritic cells

(2012) Alessandra Romagnoli et al.   Autophagy

Host Cell Autophagy Activated by Antibiotics Is Required for Their Effective Antimycobacterial Drug Action

(2012) Jwa-Jin Kim et al.   Cell Host & Microbe

The Mycobacterium tuberculosis PE Proteins Rv0285 and Rv1386 Modulate Innate Immunity and Mediate Bacillary Survival in Macrophages

(2012) Bhavana Mishra Tiwari et al.   PLoS One

The PE/PPE multigene family codes for virulence factors and is a possible source of mycobacterial antigenic variation: Perhaps more?

(2011) Yusuf Akhter et al.   BIOCHIMIE

Iron acquisition, assimilation and regulation in mycobacteria

(2011) Sharmistha Banerjee et al.   INFECTION GENETICS AND EVOLUTION

Sequence Determinants of Compaction in Intrinsically Disordered Proteins

(2010) Joseph A. Marsh et al.   BIOPHYSICAL JOURNAL

Endoplasmic reticulum stress response is involved inMycobacterium tuberculosisprotein ESAT-6-mediated apoptosis

(2010) Hong-Hee Choi et al.   FEBS LETTERS

PE_PGRS Antigens of Mycobacterium tuberculosis Induce Maturation and Activation of Human Dendritic Cells

(2010) K. Bansal et al.   JOURNAL OF IMMUNOLOGY

Induction of cell death after localization to the host cell mitochondria by the Mycobacterium tuberculosis PE_PGRS33 protein

(2010) N. Cadieux et al.   MICROBIOLOGY-SGM

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Mycobacterium tuberculosis Eis Regulates Autophagy, Inflammation, and Cell Death through Redox-dependent Signaling

(2010) Dong-Min Shin et al.   PLoS Pathogens

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

Genomic fluidity and pathogenic bacteria: applications in diagnostics, epidemiology and intervention

(2008) Niyaz Ahmed et al.   NATURE REVIEWS MICROBIOLOGY

Mycobacterium tuberculosis38-kDa Lipoprotein is Apoptogenic for Human Monocyte-derived Macrophages

(2008) A. Sanchez et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY