Mycobacterium tuberculosis RipA Dampens TLR4-Mediated Host Protective Response Using a Multi-Pronged Approach Involving Autophagy, Apoptosis, Metabolic Repurposing, and Immune Modulation

Peptidoglycan Hydrolases RipA and Ami1 Are Critical for Replication and Persistence of Mycobacterium tuberculosis in the Host

(2020) Claire Healy et al.   mBio

Protein promiscuity in drug discovery, drug-repurposing and antibiotic resistance

(2020) Munishwar N. Gupta et al.   BIOCHIMIE

An M. tuberculosis Metabolic Enzyme Moonlights as an Anti-Inflammatory Effector Protein

(2020) Tina Truong et al.   Cell Host & Microbe

Intrinsic disorder in proteins: Relevance to protein assemblies, drug design and host-pathogen interactions

(2020) Tom L. Blundell et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Immunodominant Mycobacterium tuberculosis Protein Rv1507A Elicits Th1 Response and Modulates Host Macrophage Effector Functions

(2020) Simran Kaur Arora et al.   Frontiers in Immunology

Relevance of the Warburg Effect in Tuberculosis for Host-Directed Therapy

(2020) Bridgette M. Cumming et al.   Frontiers in Cellular and Infection Microbiology

PGRS Domain of Rv0297 of Mycobacterium tuberculosis Is Involved in Modulation of Macrophage Functions to Favor Bacterial Persistence

(2020) Tarina Sharma et al.   Frontiers in Cellular and Infection Microbiology

Mycobacterial Control of Host Mitochondria: Bioenergetic and Metabolic Changes Shaping Cell Fate and Infection Outcome

(2020) Krishnaveni Mohareer et al.   Frontiers in Cellular and Infection Microbiology

Post translational modifications in tuberculosis: ubiquitination paradox

(2020) Mohd Shariq et al.   Autophagy

MmpL3 is a lipid transporter that binds trehalose monomycolate and phosphatidylethanolamine

(2019) Chih-Chia Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy

(2019) Qiyao Chai et al.   Nature Communications

Mycobacterium tuberculosis LprE Suppresses TLR2-Dependent Cathelicidin and Autophagy Expression to Enhance Bacterial Survival in Macrophages

(2019) Avinash Padhi et al.   JOURNAL OF IMMUNOLOGY

Phylogenetic and Biochemical Analyses of Mycobacterial l,d-Transpeptidases Reveal a Distinct Enzyme Class That Is Preferentially Acylated by Meropenem

(2019) Trevor A. Zandi et al.   ACS Infectious Diseases

Compromised Metabolic Reprogramming Is an Early Indicator of CD8+ T Cell Dysfunction during Chronic Mycobacterium tuberculosis Infection

(2019) Shannon L. Russell et al.   Cell Reports

Effects of Mycobacterium tuberculosis Mutant Strain Hsp16.3 Gene on Murine RAW 264.7 Macrophage Autophagy

(2018) Li Yang et al.   DNA AND CELL BIOLOGY

Metabolic reprogramming of host cells upon bacterial infection: Why shift to a Warburg-like metabolism?

(2018) Pedro Escoll et al.   FEBS Journal

Physicochemical Properties of the Mammalian Molecular Chaperone HSP60

(2018) Ryuichi Ishida et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resistin inhibits neuronal autophagy through Toll-like receptor 4

(2018) Jie Miao et al.   JOURNAL OF ENDOCRINOLOGY

Pectolinarigenin Induced Cell Cycle Arrest, Autophagy, and Apoptosis in Gastric Cancer Cell via PI3K/AKT/mTOR Signaling Pathway

(2018) Ho Lee et al.   Nutrients

TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia

(2018) Ji-Won Lee et al.   Autophagy

The ClusPro web server for protein–protein docking

(2017) Dima Kozakov et al.   Nature Protocols

Mycobacterium tuberculosis PE_PGRS41 Enhances the Intracellular Survival of M. smegmatis within Macrophages Via Blocking Innate Immunity and Inhibition of Host Defense

(2017) Wanyan Deng et al.   Scientific Reports

The Complex Link between Apoptosis and Autophagy: a Promising New Role for RB

(2016) JOÃO M.A. DELOU et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

Deletion of nuoG from the Vaccine Candidate Mycobacterium bovis BCG Δ ureC :: hly Improves Protection against Tuberculosis

(2016) Martin Gengenbacher et al.   mBio

Interaction of Mycobacterium tuberculosis Virulence Factor RipA with Chaperone MoxR1 Is Required for Transport through the TAT Secretion System

(2016) Manish Bhuwan et al.   mBio

Autophagy-Related Proteins Target Ubiquitin-Free Mycobacterial Compartment to Promote Killing in Macrophages

(2016) Aïcha Bah et al.   Frontiers in Cellular and Infection Microbiology

The innate immune response in human tuberculosis

(2015) Thomas R. Lerner et al.   CELLULAR MICROBIOLOGY

Macrophage defense mechanisms against intracellular bacteria

(2015) Günter Weiss et al.   IMMUNOLOGICAL REVIEWS

Immunologic manifestations of autophagy

(2015) Vojo Deretic et al.   JOURNAL OF CLINICAL INVESTIGATION

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

Exploiting host immunity: the Salmonella paradigm

(2015) Judith Behnsen et al.   TRENDS IN IMMUNOLOGY

Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A

(2015) Pui-Mun Wong et al.   Nature Communications

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Development of a New Generation of Vectors for Gene Expression, Gene Replacement, and Protein-Protein Interaction Studies in Mycobacteria

(2013) Amit Parikh et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

(2013) Sander Pronk et al.   BIOINFORMATICS

Autophagy in Mycobacterium tuberculosis infection: A passepartout to flush the intruder out?

(2013) Delia Goletti et al.   CYTOKINE & GROWTH FACTOR REVIEWS

How good is automated protein docking?

(2013) Dima Kozakov et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Autophagy as an innate defense against mycobacteria

(2013) Eun-Kyeong Jo   Pathogens and Disease

Roles of Autophagy in Elimination of Intracellular Bacterial Pathogens

(2013) Eun-Kyeong Jo et al.   Frontiers in Immunology

ESX-1 dependent impairment of autophagic flux byMycobacterium tuberculosisin human dendritic cells

(2012) Alessandra Romagnoli et al.   Autophagy

Maturation of autophagosomes and endosomes: A key role for Rab7

(2012) Juha M.T. Hyttinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Comparative genomic and proteomic analyses of PE/PPE multigene family of Mycobacterium tuberculosis H37Rv and H37Ra reveal novel and interesting differences with implications in virulence

(2012) Sakshi Kohli et al.   NUCLEIC ACIDS RESEARCH

BAT3 Regulates Mycobacterium tuberculosis Protein ESAT-6-Mediated Apoptosis of Macrophages

(2012) Ajay Grover et al.   PLoS One

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

(2012) U. Ohto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation

(2012) E. F. Castillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccines against Tuberculosis: Where Are We and Where Do We Need to Go?

(2012) Tom H. M. Ottenhoff et al.   PLoS Pathogens

Lipids, apoptosis, and cross-presentation: links in the chain of host defense against Mycobacterium tuberculosis

(2011) Samuel M. Behar et al.   MICROBES AND INFECTION

Immunity to Francisella

(2011) Siobhán C. Cowley et al.   Frontiers in Microbiology

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Mycobacterium tuberculosis Eis Regulates Autophagy, Inflammation, and Cell Death through Redox-dependent Signaling

(2010) Dong-Min Shin et al.   PLoS Pathogens

Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells

(2009) Chinnaswamy Jagannath et al.   NATURE MEDICINE

The NF- B Family of Transcription Factors and Its Regulation

(2009) A. Oeckinghaus et al.   Cold Spring Harbor Perspectives in Biology

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

MARCO, TLR2, and CD14 Are Required for Macrophage Cytokine Responses to Mycobacterial Trehalose Dimycolate and Mycobacterium tuberculosis

(2009) Dawn M. E. Bowdish et al.   PLoS Pathogens

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

Genomic fluidity and pathogenic bacteria: applications in diagnostics, epidemiology and intervention

(2008) Niyaz Ahmed et al.   NATURE REVIEWS MICROBIOLOGY

A Mycobacterial Enzyme Essential for Cell Division Synergizes with Resuscitation-Promoting Factor

(2008) Erik C. Hett et al.   PLoS Pathogens