Characterization of HIV-1 Infection in Microglia-Containing Human Cerebral Organoids

Human microglial models to study HIV infection and neuropathogenesis: a literature overview and comparative analyses

(2022) Stephanie B. H. Gumbs et al.   JOURNAL OF NEUROVIROLOGY

Astrocytes are HIV reservoirs in the brain: a cell type with poor HIV‐infectivity and replication but efficient cell‐to‐cell viral transfer

(2021) Valdebenito Silvana et al.   JOURNAL OF NEUROCHEMISTRY

Central Nervous System (CNS) Viral Seeding by Mature Monocytes and Potential Therapies To Reduce CNS Viral Reservoirs in the cART Era

(2021) Rosiris León-Rivera et al.   mBio

Integrated analysis of multimodal single-cell data

(2021) Yuhan Hao et al.   CELL

Applications of Brain Organoids for Infectious Diseases

(2021) Wenqiang Fan et al.   JOURNAL OF MOLECULAR BIOLOGY

HIV-Associated Neurotoxicity: The Interplay of Host and Viral Proteins

(2021) Sushama Jadhav et al.   MEDIATORS OF INFLAMMATION

Next-Generation Human Cerebral Organoids as Powerful Tools To Advance NeuroHIV Research

(2021) Thomas A. Premeaux et al.   mBio

Brain organoid: a 3D technology for investigating cellular composition and interactions in human neurological development and disease models in vitro

(2021) Oluwafemi Solomon Agboola et al.   Stem Cell Research & Therapy

Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology

(2021) Ranjie Xu et al.   Stem Cell Reports

Advances in SIV/SHIV Non-Human Primate Models of NeuroAIDS

(2021) Sonia Moretti et al.   Pathogens

Productive HIV infection in astrocytes can be established via a non-classical mechanism

(2020) Guan-Han Li et al.   AIDS

Neuroinflammation and EIF2 Signaling Persist despite Antiretroviral Treatment in an hiPSC Tri-culture Model of HIV Infection

(2020) Sean K. Ryan et al.   Stem Cell Reports

Deconstructing and reconstructing the human brain with regionally specified brain organoids

(2020) Yangfei Xiang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

HIV infects astrocytes in vivo and egresses from the brain to the periphery

(2020) Victoria Lutgen et al.   PLoS Pathogens

Robust production of uniform human cerebral organoids from pluripotent stem cells

(2020) Adam A Sivitilli et al.   Life Science Alliance

Important role of microglia in HIV-1 associated neurocognitive disorders and the molecular pathways implicated in its pathogenesis

(2020) A Borrajo et al.   ANNALS OF MEDICINE

Modeling HIV-1 neuropathogenesis using three-dimensional human brain organoids (hBORGs) with HIV-1 infected microglia

(2020) Roberta S. dos Reis et al.   Scientific Reports

Comparative analysis of human microglial models for studies of HIV replication and pathogenesis

(2020) Mohammad A. Rai et al.   Retrovirology

A core transcriptional signature of human microglia: Derivation and utility in describing region-dependent alterations associated with Alzheimer's disease

(2019) Anirudh Patir et al.   GLIA

Correction to: Astrocytes as an HIV CNS reservoir: highlights and reflections of an NIMH-sponsored symposium

(2019) Lena Al-Harthi et al.   JOURNAL OF NEUROVIROLOGY

Functionalization of Brain Region-specific Spheroids with Isogenic Microglia-like Cells

(2019) Liqing Song et al.   Scientific Reports

Brain Organoids as Tools for Modeling Human Neurodevelopmental Disorders

(2019) Jason W. Adams et al.   PHYSIOLOGY

Myeloid and CD4 T Cells Comprise the Latent Reservoir in Antiretroviral Therapy-Suppressed SIVmac251-Infected Macaques

(2019) Celina M. Abreu et al.   mBio

Organoid single-cell genomic atlas uncovers human-specific features of brain development

(2019) Sabina Kanton et al.   NATURE

Microglial Cells: The Main HIV-1 Reservoir in the Brain

(2019) Clementine Wallet et al.   Frontiers in Cellular and Infection Microbiology

Brain macrophages harbor latent, infectious simian immunodeficiency virus

(2019) Celina Abreu et al.   AIDS

Cross-talk between microglia and neurons regulates HIV latency

(2019) David Alvarez-Carbonell et al.   PLoS Pathogens

Ultradeep single-molecule real-time sequencing of HIV envelope reveals complete compartmentalization of highly macrophage-tropic R5 proviral variants in brain and CXCR4-using variants in immune and peripheral tissues

(2018) Robin L. Brese et al.   JOURNAL OF NEUROVIROLOGY

Optimizing animal models for HIV-associated CNS dysfunction and CNS reservoir research

(2018) Jeymohan Joseph   JOURNAL OF NEUROVIROLOGY

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Generation of human brain region–specific organoids using a miniaturized spinning bioreactor

(2018) Xuyu Qian et al.   Nature Protocols

Macrophages but not Astrocytes Harbor HIV DNA in the Brains of HIV-1-Infected Aviremic Individuals on Suppressive Antiretroviral Therapy

(2018) Allen Ko et al.   Journal of Neuroimmune Pharmacology

Brain is a potential sanctuary for subtype C HIV-1 irrespective of ART treatment outcome

(2018) For Yue Tso et al.   PLoS One

Microglia innately develop within cerebral organoids

(2018) Paul R. Ormel et al.   Nature Communications

Microglia Increase Inflammatory Responses in iPSC-Derived Human BrainSpheres

(2018) Celina Monteiro Abreu et al.   Frontiers in Microbiology

An SIV/macaque model targeted to study HIV-associated neurocognitive disorders

(2017) Sarah E. Beck et al.   JOURNAL OF NEUROVIROLOGY

Humanized mice: models for evaluating NeuroHIV and cure strategies

(2017) Jenna B. Honeycutt et al.   JOURNAL OF NEUROVIROLOGY

Cell diversity and network dynamics in photosensitive human brain organoids

(2017) Giorgia Quadrato et al.   NATURE

Guided self-organization and cortical plate formation in human brain organoids

(2017) Madeline A Lancaster et al.   NATURE BIOTECHNOLOGY

Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations

(2017) Susanne C van den Brink et al.   NATURE METHODS

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

(2017) Edsel M. Abud et al.   NEURON

Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells

(2017) Steven A. Sloan et al.   NEURON

Brain Macrophages in Simian Immunodeficiency Virus-Infected, Antiretroviral-Suppressed Macaques: a Functional Latent Reservoir

(2017) Claudia R. Avalos et al.   mBio

Astrocytes Resist HIV-1 Fusion but Engulf Infected Macrophage Material

(2017) Rebecca A. Russell et al.   Cell Reports

A combinational CRISPR/Cas9 gene-editing approach can halt HIV replication and prevent viral escape

(2017) Robert Jan Lebbink et al.   Scientific Reports

HIV-infected macrophages and microglia that survive acute infection become viral reservoirs by a mechanism involving Bim

(2017) Paul Castellano et al.   Scientific Reports

Autoantibody pathogenicity in a multifocal motor neuropathy induced pluripotent stem cell-derived model

(2016) Oliver Harschnitz et al.   ANNALS OF NEUROLOGY

Characterizing primary human microglia: A comparative study with myeloid subsets and culture models

(2016) J. Melief et al.   GLIA

Quantitation of Productively Infected Monocytes and Macrophages of Simian Immunodeficiency Virus-Infected Macaques

(2016) Claudia R. Avalos et al.   JOURNAL OF VIROLOGY

A Single-Cell Transcriptome Atlas of the Human Pancreas

(2016) Mauro J. Muraro et al.   Cell Systems

Cell-to-cell contact facilitates HIV transmission from lymphocytes to astrocytes via CXCR4

(2015) Guan-Han Li et al.   AIDS

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

Human cerebral organoids recapitulate gene expression programs of fetal neocortex development

(2015) J. Gray Camp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell–cell contact viral transfer contributes to HIV infection and persistence in astrocytes

(2014) Xiaoyu Luo et al.   JOURNAL OF NEUROVIROLOGY

Validation of noise models for single-cell transcriptomics

(2014) Dominic Grün et al.   NATURE METHODS

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

HIV-1 Entry and Trans-Infection of Astrocytes Involves CD81 Vesicles

(2014) Lachlan R. Gray et al.   PLoS One

Endocytosis-mediated HIV-1 entry and its significance in the elusive behavior of the virus in astrocytes

(2014) Ashok Chauhan et al.   VIROLOGY

HIV-associated neurocognitive disorder

(2013) David B Clifford et al.   LANCET INFECTIOUS DISEASES

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

HIV-1-Related Central Nervous System Disease: Current Issues in Pathogenesis, Diagnosis, and Treatment

(2013) S. Spudich et al.   Cold Spring Harbor Perspectives in Medicine

Modeling HIV-associated neurocognitive disorders in mice: new approaches in the changing face of HIV neuropathogenesis

(2012) L. B. Jaeger et al.   Disease Models & Mechanisms

Brain Cell Reservoirs of Latent Virus in Presymptomatic HIV-Infected Individuals

(2011) Katherine A. Thompson et al.   AMERICAN JOURNAL OF PATHOLOGY

Cognitive dysfunction in HIV patients despite long-standing suppression of viremia

(2010) Samanta Simioni et al.   AIDS

HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

(2010) R. K. Heaton et al.   NEUROLOGY

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

Pathogenesis of HIV in the Central Nervous System

(2010) Victor Valcour et al.   Current HIV/AIDS Reports

Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia

(2009) Melissa J. Churchill et al.   ANNALS OF NEUROLOGY