Central Nervous System (CNS) Viral Seeding by Mature Monocytes and Potential Therapies To Reduce CNS Viral Reservoirs in the cART Era

Simian Immunodeficiency Virus-Infected Memory CD4+ T Cells Infiltrate to the Site of Infected Macrophages in the Neuroparenchyma of a Chronic Macaque Model of Neurological Complications of AIDS

(2020) Cheri A. Lee et al.   mBio

Interactions of Monocytes, HIV, and ART Identified by an Innovative scRNAseq Pipeline: Pathways to Reservoirs and HIV-Associated Comorbidities

(2020) Rosiris León-Rivera et al.   mBio

HIV-1 reservoirs in urethral macrophages of patients under suppressive antiretroviral therapy

(2019) Yonatan Ganor et al.   Nature Microbiology

HIV-1 is rarely detected in blood and colon myeloid cells during viral-suppressive antiretroviral therapy

(2019) Amélie Cattin et al.   AIDS

Infectious virus persists in CD4+ T cells and macrophages in ART-suppressed SIV-infected Macaques

(2019) Celina M. Abreu et al.   JOURNAL OF VIROLOGY

Myeloid and CD4 T Cells Comprise the Latent Reservoir in Antiretroviral Therapy-Suppressed SIVmac251-Infected Macaques

(2019) Celina M. Abreu et al.   mBio

Nef-induced CCL2 Expression Contributes to HIV/SIV Brain Invasion and Neuronal Dysfunction

(2019) Michael H. Lehmann et al.   Frontiers in Immunology

Improved Cognitive Performance and Reduced Monocyte Activation in Virally Suppressed Chronic HIV Following Dual CCR2 and CCR5 Antagonism

(2018) Michelle L. D’Antoni et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

T cells establish and maintain CNS viral infection in HIV-infected humanized mice

(2018) Jenna B. Honeycutt et al.   JOURNAL OF CLINICAL INVESTIGATION

CCR2 on Peripheral Blood CD14+CD16+ Monocytes Correlates with Neuronal Damage, HIV-Associated Neurocognitive Disorders, and Peripheral HIV DNA: reseeding of CNS reservoirs?

(2018) Mike Veenstra et al.   Journal of Neuroimmune Pharmacology

Associations between HIV-1 DNA copy number, proviral transcriptional activity, and plasma viremia in individuals off or on suppressive antiretroviral therapy

(2018) Feiyu Hong et al.   VIROLOGY

EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment

(2018) Chao-Jiang Gu et al.   PLoS Pathogens

Macrophages but not Astrocytes Harbor HIV DNA in the Brains of HIV-1-Infected Aviremic Individuals on Suppressive Antiretroviral Therapy

(2018) Allen Ko et al.   Journal of Neuroimmune Pharmacology

HIV-Nef Protein Persists in the Lungs of Aviremic HIV Patients and Induces Endothelial Cell Death

(2018) Sarvesh Chelvanambi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Frontline Science: CXCR7 mediates CD14 + CD16 + monocyte transmigration across the blood brain barrier: a potential therapeutic target for NeuroAIDS

(2017) Mike Veenstra et al.   JOURNAL OF LEUKOCYTE BIOLOGY

HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy

(2017) Jenna B Honeycutt et al.   NATURE MEDICINE

Clinical Relevance of Total HIV DNA in Peripheral Blood Mononuclear Cell Compartments as a Biomarker of HIV-Associated Neurocognitive Disorders (HAND)

(2017) Vurayai Ruhanya et al.   Viruses-Basel

Brain Macrophages in Simian Immunodeficiency Virus-Infected, Antiretroviral-Suppressed Macaques: a Functional Latent Reservoir

(2017) Claudia R. Avalos et al.   mBio

Mechanisms of CNS Viral Seeding by HIV + CD14 + CD16 + Monocytes: Establishment and Reseeding of Viral Reservoirs Contributing to HIV-Associated Neurocognitive Disorders

(2017) Mike Veenstra et al.   mBio

HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study

(2017) Timothy J. Henrich et al.   PLOS MEDICINE

Sensitive quantification of the HIV-1 reservoir in gut-associated lymphoid tissue

(2017) Sara Morón-López et al.   PLoS One

HIV-infected macrophages and microglia that survive acute infection become viral reservoirs by a mechanism involving Bim

(2017) Paul Castellano et al.   Scientific Reports

Macrophages sustain HIV replication in vivo independently of T cells

(2016) Jenna B. Honeycutt et al.   JOURNAL OF CLINICAL INVESTIGATION

Quantitation of Productively Infected Monocytes and Macrophages of Simian Immunodeficiency Virus-Infected Macaques

(2016) Claudia R. Avalos et al.   JOURNAL OF VIROLOGY

HIV DNA Is Frequently Present within Pathologic Tissues Evaluated at Autopsy from Combined Antiretroviral Therapy-Treated Patients with Undetectable Viral Loads

(2016) Susanna L. Lamers et al.   JOURNAL OF VIROLOGY

Transient Migration of Large Numbers of CD14++ CD16+ Monocytes to the Draining Lymph Node after Onset of Inflammation

(2016) Hege Lund et al.   Frontiers in Immunology

Dopamine Increases CD14+CD16+ Monocyte Migration and Adhesion in the Context of Substance Abuse and HIV Neuropathogenesis

(2015) Jacqueline S. Coley et al.   PLoS One

Antiretroviral-Free HIV-1 Remission and Viral Rebound After Allogeneic Stem Cell Transplantation

(2014) Timothy J. Henrich et al.   ANNALS OF INTERNAL MEDICINE

The dual CCR5 and CCR2 inhibitor cenicriviroc does not redistribute HIV into extracellular space: implications for plasma viral load and intracellular DNA decline

(2014) V. G. Kramer et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

JAM-A and ALCAM are therapeutic targets to inhibit diapedesis across the BBB of CD14+ CD16+ monocytes in HIV-infected individuals

(2014) Dionna W. Williams et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cenicriviroc blocks HIV entry but does not lead to redistribution of HIV into extracellular space like maraviroc

(2014) Victor Kramer et al.   Journal of the International AIDS Society

CD4 Depletion in SIV-Infected Macaques Results in Macrophage and Microglia Infection with Rapid Turnover of Infected Cells

(2014) Luca Micci et al.   PLoS Pathogens

Anti-α4 Antibody Treatment Blocks Virus Traffic to the Brain and Gut Early, and Stabilizes CNS Injury Late in Infection

(2014) Jennifer H. Campbell et al.   PLoS Pathogens

Elevated sCD163 in plasma but not cerebrospinal fluid is a marker of neurocognitive impairment in HIV infection

(2013) Tricia H. Burdo et al.   AIDS

Drug Induced Increases in CNS Dopamine Alter Monocyte, Macrophage and T Cell Functions: Implications for HAND

(2013) Peter J. Gaskill et al.   Journal of Neuroimmune Pharmacology

Detection of anti-tat antibodies in CSF of individuals with HIV-associated neurocognitive disorders

(2013) M. Bachani et al.   JOURNAL OF NEUROVIROLOGY

Cytokines in CSF correlate with HIV-associated neurocognitive disorders in the post-HAART era in China

(2013) Lin Yuan et al.   JOURNAL OF NEUROVIROLOGY

Highly Precise Measurement of HIV DNA by Droplet Digital PCR

(2013) Matthew C. Strain et al.   PLoS One

Mechanisms of HIV Entry into the CNS: Increased Sensitivity of HIV Infected CD14+CD16+ Monocytes to CCL2 and Key Roles of CCR2, JAM-A, and ALCAM in Diapedesis

(2013) Dionna W. Williams et al.   PLoS One

Monocyte Activation Markers in Cerebrospinal Fluid Associated With Impaired Neurocognitive Testing in Advanced HIV Infection

(2012) Anupa Kamat et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Neurovirological Correlation With HIV-Associated Neurocognitive Disorders and Encephalitis in a HAART-Era Cohort

(2012) Benjamin B. Gelman et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Central Nervous System Viral Invasion and Inflammation During Acute HIV Infection

(2012) Victor Valcour et al.   JOURNAL OF INFECTIOUS DISEASES

Cognitive Performance Related to HIV-1-Infected Monocytes

(2012) Ian Kusao et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

Persistence of HIV-associated cognitive impairment, inflammation, and neuronal injury in era of highly active antiretroviral treatment

(2011) Jarek Harezlak et al.   AIDS

Prevalence of non-confounded HIV-associated neurocognitive impairment in the context of plasma HIV RNA suppression

(2011) Lucette A. Cysique et al.   JOURNAL OF NEUROVIROLOGY

Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication

(2010) Tae-Wook Chun et al.   AIDS

HIV Type 1 Nef Is Released from Infected Cells in CD45+ Microvesicles and Is Present in the Plasma of HIV-Infected Individuals

(2010) A.D. Raymond et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Characterization of monocyte maturation/differentiation that facilitates their transmigration across the blood–brain barrier and infection by HIV: Implications for NeuroAIDS

(2010) Clarisa M. Buckner et al.   CELLULAR IMMUNOLOGY

CD163/CD16 Coexpression by Circulating Monocytes/Macrophages in HIV: Potential Biomarkers for HIV Infection and AIDS Progression

(2008) Tracy Fischer-Smith et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

HIV-1 Infection of Bone Marrow Hematopoietic Progenitor Cells and Their Role in Trafficking and Viral Dissemination

(2008) Aikaterini Alexaki et al.   PLoS Pathogens