An SIV/macaque model targeted to study HIV-associated neurocognitive disorders

A humanized mouse-based HIV-1 viral outgrowth assay with higher sensitivity than in vitro qVOA in detecting latently infected cells from individuals on ART with undetectable viral loads

(2017) Paige Charlins et al.   VIROLOGY

Inflammatory Function of CX3CR1 + CD8 + T Cells in Treated HIV Infection Is Modulated by Platelet Interactions

(2016) Joseph C. Mudd et al.   JOURNAL OF INFECTIOUS DISEASES

Central nervous system-specific consequences of simian immunodeficiency virus Gag escape from major histocompatibility complex class I-mediated control

(2016) Sarah E. Beck et al.   JOURNAL OF NEUROVIROLOGY

Quantitation of Productively Infected Monocytes and Macrophages of Simian Immunodeficiency Virus-Infected Macaques

(2016) Claudia R. Avalos et al.   JOURNAL OF VIROLOGY

HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment

(2016) Deanna Saylor et al.   Nature Reviews Neurology

Paving the path to HIV neurotherapy: Predicting SIV CNS disease

(2015) Sarah E. Beck et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A Murine Viral Outgrowth Assay to Detect Residual HIV Type 1 in Patients With Undetectable Viral Loads

(2015) Kelly A. Metcalf Pate et al.   JOURNAL OF INFECTIOUS DISEASES

Persistent Peripheral Nervous System Damage in Simian Immunodeficiency Virus—Infected Macaques Receiving Antiretroviral Therapy

(2015) Jamie L. Dorsey et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuroinflammation and Virus Replication in the Spinal Cord of Simian Immunodeficiency Virus–Infected Macaques

(2015) Lisa M. Mangus et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Macaque species susceptibility to simian immunodeficiency virus: increased incidence of SIV central nervous system disease in pigtailed macaques versus rhesus macaques

(2015) Sarah E. Beck et al.   JOURNAL OF NEUROVIROLOGY

Loss of Corneal Sensory Nerve Fibers in SIV-Infected Macaques

(2014) Jamie L. Dorsey et al.   AMERICAN JOURNAL OF PATHOLOGY

Human Dermal CD14 + Cells Are a Transient Population of Monocyte-Derived Macrophages

(2014) Naomi McGovern et al.   IMMUNITY

Characterization of Platelet-Monocyte Complexes in HIV-1-Infected Individuals: Possible Role in HIV-Associated Neuroinflammation

(2014) M. V. Singh et al.   JOURNAL OF IMMUNOLOGY

Combination fluconazole/paroxetine treatment is neuroprotective despite ongoing neuroinflammation and viral replication in an SIV model of HIV neurological disease

(2014) Kelly A. Meulendyke et al.   JOURNAL OF NEUROVIROLOGY

Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system

(2014) Cagla Akay et al.   JOURNAL OF NEUROVIROLOGY

Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys

(2014) James B. Whitney et al.   NATURE

Neuroprotective maraviroc monotherapy in simian immunodeficiency virus-infected macaques

(2013) Kathleen M. Kelly et al.   AIDS

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

(2013) Ya-Chi Ho et al.   CELL

14-3-3 Protein in CSF Reflects SIV-Mediated Pre-Synaptic Damage

(2013) Kristi Helke et al.   CURRENT HIV RESEARCH

Monocyte subset accumulation in the human heart following acute myocardial infarction and the role of the spleen as monocyte reservoir

(2013) A. M. van der Laan et al.   EUROPEAN HEART JOURNAL

Platelet Activation and Platelet-Monocyte Aggregate Formation Contribute to Decreased Platelet Count During Acute Simian Immunodeficiency Virus Infection in Pig-tailed Macaques

(2013) Kelly A. Metcalf Pate et al.   JOURNAL OF INFECTIOUS DISEASES

Genome-wide association study of neurocognitive impairment and dementia in HIV-infected adults

(2012) Andrew J. Levine et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Early Emergence and Selection of a SIV-LTR C/EBP Site Variant in SIV-Infected Macaques That Increases Virus Infectivity

(2012) Shruthi Ravimohan et al.   PLoS One

Macrophage-Mediated Dorsal Root Ganglion Damage Precedes Altered Nerve Conduction in SIV-Infected Macaques

(2011) Victoria A. Laast et al.   AMERICAN JOURNAL OF PATHOLOGY

Neurocognitive dysfunction in the highly active antiretroviral therapy era

(2011) Nomvuyo Z. Mothobi et al.   CURRENT OPINION IN INFECTIOUS DISEASES

CD8+ lymphocyte depletion without SIV infection does not produce metabolic changes or pathological abnormalities in the rhesus macaque brain

(2011) E.-M. Ratai et al.   JOURNAL OF MEDICAL PRIMATOLOGY

Monocyte Mobilization, Activation Markers, and Unique Macrophage Populations in the Brain: Observations from SIV Infected Monkeys Are Informative with Regard to Pathogenic Mechanisms of HIV Infection in Humans

(2011) Kenneth Williams et al.   Journal of Neuroimmune Pharmacology

Replication-Competent Simian Immunodeficiency Virus (SIV) Gag Escape Mutations Archived in Latent Reservoirs during Antiretroviral Treatment of SIV-Infected Macaques

(2011) S. E. Queen et al.   JOURNAL OF VIROLOGY

Simian Immunodeficiency Virus–Infected Macaques Treated with Highly Active Antiretroviral Therapy Have Reduced Central Nervous System Viral Replication and Inflammation but Persistence of Viral DNA

(2010) M. Christine Zink et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

(2010) R. K. Heaton et al.   NEUROLOGY

A Simian Immunodeficiency Virus-Infected Macaque Model To Study Viral Reservoirs That Persist during Highly Active Antiretroviral Therapy

(2009) J. B. Dinoso et al.   JOURNAL OF VIROLOGY

Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

(2009) F. K. Swirski et al.   SCIENCE

Natural Host Genetic Resistance to Lentiviral CNS Disease: A Neuroprotective MHC Class I Allele in SIV-Infected Macaques

(2008) Joseph L. Mankowski et al.   PLoS One

Inflammatory and Coagulation Biomarkers and Mortality in Patients with HIV Infection

(2008) Lewis H Kuller et al.   PLOS MEDICINE