The amoeboid state as part of the epithelial-to-mesenchymal transition programme

Belumosudil for Chronic Graft-versus-Host Disease (cGVHD) After 2 or More Prior Lines of Therapy: The ROCKstar Study

(2021) Corey S Cutler et al.   BLOOD

A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma

(2021) Oscar Maiques et al.   BRITISH JOURNAL OF CANCER

RASSF1C oncogene elicits amoeboid invasion, cancer stemness, and extracellular vesicle release via a SRC/Rho axis

(2021) Maria Laura Tognoli et al.   EMBO JOURNAL

Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance

(2020) Jose L. Orgaz et al.   CANCER CELL

AVID200, first-in-class TGF-beta 1 and 3 selective and potent inhibitor: Safety and biomarker results of a phase I monotherapy dose-escalation study in patients with advanced solid tumors.

(2020) Timothy A Yap et al.   JOURNAL OF CLINICAL ONCOLOGY

Biomarkers and overall survival in patients with advanced hepatocellular carcinoma treated with TGF-βRI inhibitor galunisertib

(2020) Gianluigi Giannelli et al.   PLoS One

High-throughput transcriptomic and proteomic profiling of mesenchymal-amoeboid transition in 3D collagen

(2020) Vladimír Čermák et al.   Scientific Data

Targeting Rho GTPase Signaling Networks in Cancer

(2020) Natasha S. Clayton et al.   Frontiers in Cell and Developmental Biology

Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids

(2020) Nikos Koundouros et al.   CELL

First-in-Human Study of AT13148, a Dual ROCK-AKT Inhibitor in Patients with Solid Tumors

(2020) Robert McLeod et al.   CLINICAL CANCER RESEARCH

An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells

(2020) Shogo Kumagai et al.   IMMUNITY

Small Molecule NF-κB Pathway Inhibitors in Clinic

(2020) Venkataramanan Ramadass et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Innovative Potential of Statins in Cancer: New Targets for New Therapies

(2020) Elisabetta Di Bello et al.   Frontiers in Chemistry

CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function, migration, and invasion

(2020) Aaron J. Farrugia et al.   JOURNAL OF CELL BIOLOGY

Targeting STAT3 in Cancer Immunotherapy

(2020) Sailan Zou et al.   Molecular Cancer

WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion

(2020) Irene Rodriguez-Hernandez et al.   Nature Communications

E-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow

(2020) Cecilia Grimaldi et al.   Nature Communications

Membrane Tension Gates ERK-Mediated Regulation of Pluripotent Cell Fate

(2020) Henry De Belly et al.   Cell Stem Cell

Cell migration: implications for repair and regeneration in joint disease

(2019) Feini Qu et al.   Nature Reviews Rheumatology

HIF Inhibitors: Status of Current Clinical Development

(2019) Jaleh Fallah et al.   Current Oncology Reports

Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment

(2019) Mirella Georgouli et al.   CELL

SMAD signaling promotes melanoma metastasis independently of phenotype switching

(2019) Eylul Tuncer et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression Profiling of Circulating Tumor Cells in Pancreatic Ductal Adenocarcinoma Patients: Biomarkers Predicting Overall Survival

(2019) Consuelo Amantini et al.   Frontiers in Oncology

Downregulation of Epidermal Growth Factor Receptor in hepatocellular carcinoma facilitates Transforming Growth Factor-β-induced epithelial to amoeboid transition

(2019) Judit López-Luque et al.   CANCER LETTERS

Mechanisms of 3D cell migration

(2019) Kenneth M. Yamada et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin

(2019) Koen Schipper et al.   Nature Communications

Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer

(2019) Haisheng Zhang et al.   Cancer Discovery

ROCK2 Confers Acquired Gemcitabine Resistance in Pancreatic Cancer Cells by Upregulating Transcription Factor ZEB1

(2019) Yang Zhou et al.   Cancers

Current perspectives on statins as potential anti-cancer therapeutics: clinical outcomes and underlying molecular mechanisms

(2019) Ali Fatehi Hassanabad   Translational Lung Cancer Research

Vascular Stem/Progenitor Cell Migration and Differentiation in Atherosclerosis

(2018) Baoqi Yu et al.   ANTIOXIDANTS & REDOX SIGNALING

The stiff RhoAd from mevalonate to mutant p53

(2018) Giovanni Sorrentino et al.   CELL DEATH AND DIFFERENTIATION

Regulation of neural crest development by the formin family protein Daam1

(2018) Olga Ossipova et al.   GENESIS

Bone marrow-derived mesenchymal stem cells promote invasiveness and transendothelial migration of osteosarcoma cells via a mesenchymal to amoeboid transition

(2018) Laura Pietrovito et al.   Molecular Oncology

An overview of mammographic density and its association with breast cancer

(2018) Shayan Shaghayeq Nazari et al.   Breast Cancer

Targeting IKKβ in Cancer: Challenges and Opportunities for the Therapeutic Utilisation of IKKβ Inhibitors

(2018) Jack Prescott et al.   Cells

Targeting Eph/ephrin system in cancer therapy

(2017) Alessio Lodola et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Mechanoreciprocity in cell migration

(2017) Sjoerd van Helvert et al.   NATURE CELL BIOLOGY

Rho-associated kinase is a therapeutic target in neuroblastoma

(2017) Cecilia Dyberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of ERα induces amoeboid-like migration of breast cancer cells by downregulating vinculin

(2017) Yuan Gao et al.   Nature Communications

Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells

(2017) A J Rice et al.   Oncogenesis

Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic cells and increase endothelial permeability: their emerging role in tumor heterogeneity

(2017) Odessa Schillaci et al.   Scientific Reports

Steering cell migration by alternating blebs and actin-rich protrusions

(2016) Alba Diz-Muñoz et al.   BMC BIOLOGY

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

The Actin Cortex: A Bridge between Cell Shape and Function

(2016) Kevin J. Chalut et al.   DEVELOPMENTAL CELL

Modes of invasion during tumour dissemination

(2016) Pahini Pandya et al.   Molecular Oncology

ODZ1 allows glioblastoma to sustain invasiveness through a Myc-dependent transcriptional upregulation of RhoA

(2016) A Talamillo et al.   ONCOGENE

The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination

(2016) E Crosas-Molist et al.   ONCOGENE

IL-1 drives breast cancer growth and bone metastasis in vivo

(2016) Ingunn Holen et al.   Oncotarget

Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis

(2016) Sandra Kümper et al.   eLife

Twist1-positive epithelial cells retain adhesive and proliferative capacity throughout dissemination

(2016) Eliah R. Shamir et al.   Biology Open

Rho Kinase Inhibitors Block Melanoma Cell Migration and Inhibit Metastasis

(2015) Amine Sadok et al.   CANCER RESEARCH

Cortical Contractility Triggers a Stochastic Switch to Fast Amoeboid Cell Motility

(2015) Verena Ruprecht et al.   CELL

Confinement and Low Adhesion Induce Fast Amoeboid Migration of Slow Mesenchymal Cells

(2015) Yan-Jun Liu et al.   CELL

Rho-Signaling-Directed YAP/TAZ Activity Underlies the Long-Term Survival and Expansion of Human Embryonic Stem Cells

(2015) Masatoshi Ohgushi et al.   Cell Stem Cell

Interleukin-6 as a Therapeutic Target

(2015) J.-F. Rossi et al.   CLINICAL CANCER RESEARCH

TGF-β-Induced Transcription Sustains Amoeboid Melanoma Migration and Dissemination

(2015) Gaia Cantelli et al.   CURRENT BIOLOGY

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Competition for actin between two distinct F-actin networks defines a bistable switch for cell polarization

(2015) Alexis J. Lomakin et al.   NATURE CELL BIOLOGY

Targeting the TGFβ pathway for cancer therapy

(2015) Cindy Neuzillet et al.   PHARMACOLOGY & THERAPEUTICS

Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression

(2015) Xin Ye et al.   TRENDS IN CELL BIOLOGY

Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer

(2015) Derek C. Marshall et al.   PLoS One

Interleukin-1α neutralisation in patients with cancer

(2014) Charles Anthony Dinarello   LANCET ONCOLOGY

Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma

(2014) Miwako Kakiuchi et al.   NATURE GENETICS

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Direct in Vivo RNAi Screen Unveils Myosin IIa as a Tumor Suppressor of Squamous Cell Carcinomas

(2014) D. Schramek et al.   SCIENCE

Diverse matrix metalloproteinase functions regulate cancer amoeboid migration

(2014) Jose L. Orgaz et al.   Nature Communications

Metastasis of aggressive amoeboid sarcoma cells is dependent on Rho/ROCK/MLC signaling

(2013) Jan Kosla et al.   Cell Communication and Signaling

The role and regulation of blebs in cell migration

(2013) Ewa K Paluch et al.   CURRENT OPINION IN CELL BIOLOGY

E-cadherin-integrin crosstalk in cancer invasion and metastasis

(2013) M. Canel et al.   JOURNAL OF CELL SCIENCE

EphA2-mediated mesenchymal–amoeboid transition induced by endothelial progenitor cells enhances metastatic spread due to cancer-associated fibroblasts

(2012) Elisa Giannoni et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cancer Associated Fibroblasts Exploit Reactive Oxygen Species Through a Proinflammatory Signature Leading to Epithelial Mesenchymal Transition and Stemness

(2011) Elisa Giannoni et al.   ANTIOXIDANTS & REDOX SIGNALING

Rho Kinase Regulates the Survival and Transformation of Cells Bearing Oncogenic Forms of KIT, FLT3, and BCR-ABL

(2011) Raghuveer Singh Mali et al.   CANCER CELL

ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma

(2011) Victoria Sanz-Moreno et al.   CANCER CELL

Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance

(2011) Ron C.J. Schackmann et al.   JOURNAL OF CLINICAL INVESTIGATION

RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation

(2011) Fernando Calvo et al.   NATURE CELL BIOLOGY

Adult Skeletal Muscle Stem Cell Migration Is Mediated by a Blebbing/Amoeboid Mechanism

(2011) Anthony Otto et al.   REJUVENATION RESEARCH

Ovarian Cancer Spheroids Use Myosin-Generated Force to Clear the Mesothelium

(2011) Marcin P. Iwanicki et al.   Cancer Discovery

A prospective phase II study of 2-methoxyestradiol administered in combination with bevacizumab in patients with metastatic carcinoid tumors

(2010) Matthew H. Kulke et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Blebbing confers resistance against cell lysis

(2010) E B Babiychuk et al.   CELL DEATH AND DIFFERENTIATION

Dictyostelium amoebae and neutrophils can swim

(2010) N. P. Barry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-muscle myosin II regulates survival threshold of pluripotent stem cells

(2010) Andrea Walker et al.   Nature Communications

Crossing the endothelium

(2010) Julia Woodward   Cell Adhesion & Migration

EphA2 Reexpression Prompts Invasion of Melanoma Cells Shifting from Mesenchymal to Amoeboid-like Motility Style

(2009) M. Parri et al.   CANCER RESEARCH

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement

(2008) Victoria Sanz-Moreno et al.   CELL

DOCK10-Mediated Cdc42 Activation Is Necessary for Amoeboid Invasion of Melanoma Cells

(2008) Gilles Gadea et al.   CURRENT BIOLOGY

Interstitial leukocyte migration and immune function

(2008) Peter Friedl et al.   NATURE IMMUNOLOGY