Occurrence of early afterdepolarization under healthy or hypertrophic cardiomyopathy conditions in the human ventricular endocardial myocyte: In silico study using 109 torsadogenic or non-torsadogenic compounds

Inflammation as a Risk Factor in Cardiotoxicity: An Important Consideration for Screening During Drug Development

(2021) Chiara Campana et al.   Frontiers in Pharmacology

Multi-scale approaches for the simulation of cardiac electrophysiology: II - tissue-level structure and function

(2020) Alan P. Benson et al.   METHODS

Multi-scale approaches for the simulation of cardiac electrophysiology: I - sub-cellular and stochastic calcium dynamics from cell to organ

(2020) Michael A. Colman et al.   METHODS

Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk Assessment

(2020) Xin Zhou et al.   Frontiers in Pharmacology

Human Purkinje in silico model enables mechanistic investigations into automaticity and pro-arrhythmic abnormalities

(2020) Cristian Trovato et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiomyocyte calcium handling in health and disease: Insights from in vitro and in silico studies

(2020) Henry Sutanto et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

In-Silico Classifiers for the Assessment of Drug Proarrhythmicity

(2020) Jordi Llopis Lorente et al.   Journal of Chemical Information and Modeling

Teaching cardiac excitation-contraction coupling using a mathematical computer simulation model of human ventricular myocytes

(2020) Young Keul Jeon et al.   ADVANCES IN PHYSIOLOGY EDUCATION

Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior

(2020) András Varró et al.   PHYSIOLOGICAL REVIEWS

Drug‐induced Shortening of the Electromechanical Window is an Effective Biomarker for in Silico Prediction of Clinical Risk of Arrhythmias

(2019) Elisa Passini et al.   BRITISH JOURNAL OF PHARMACOLOGY

General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy

(2019) Zhihua Li et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Relationship of clinical adverse event reports to models of arrhythmia risk

(2019) Nicholas Ether et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Improving prediction of torsadogenic risk in the CiPA in silico model by appropriately accounting for clinical exposure

(2019) Derek J. Leishman   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block

(2019) Jakub Tomek et al.   eLife

Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative

(2018) Zhihua Li et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Altered Ca2+ and Na+ Homeostasis in Human Hypertrophic Cardiomyopathy: Implications for Arrhythmogenesis

(2018) Raffaele Coppini et al.   Frontiers in Physiology

Impact of disease state on arrhythmic event detection by action potential modelling in cardiac safety pharmacology

(2018) Bernard Christophe et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Cardiologist's point of view: Novel ECG biomarkers and in silico models for proarrhythmic risk prediction: Are we ready?

(2017) Jay W. Mason   JOURNAL OF ELECTROCARDIOLOGY

Significance of integrated in silico transmural ventricular wedge preparation models of human non-failing and failing hearts for safety evaluation of drug candidates

(2017) Taeko Kubo et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Early afterdepolarisation tendency as a simulated pro-arrhythmic risk indicator

(2017) Beth McMillan et al.   Toxicology Research

Novel Two-Step Classifier for Torsades de Pointes Risk Stratification from Direct Features

(2017) Jaimit Parikh et al.   Frontiers in Pharmacology

Uncertainty Quantification Reveals the Importance of Data Variability and Experimental Design Considerations for in Silico Proarrhythmia Risk Assessment

(2017) Kelly C. Chang et al.   Frontiers in Physiology

Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment

(2017) Sara Dutta et al.   Frontiers in Physiology

Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity

(2017) Elisa Passini et al.   Frontiers in Physiology

Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy

(2016) Elisa Passini et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Evolution of strategies to improve preclinical cardiac safety testing

(2016) Gary Gintant et al.   NATURE REVIEWS DRUG DISCOVERY

Comprehensive in vitro Proarrhythmia Assay (C i PA): Pending issues for successful validation and implementation

(2016) Icilio Cavero et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Simulation of early after-depolarisation in non-failing human ventricular myocytes: Can this help cardiac safety pharmacology?

(2014) Bernard Christophe   Pharmacological Reports

EAD and DAD mechanisms analyzed by developing a new human ventricular cell model

(2014) K. Asakura et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium

(2013) Philip T. Sager et al.   AMERICAN HEART JOURNAL

Early afterdepolarizations in cardiac myocytes: beyond reduced repolarization reserve

(2013) Zhilin Qu et al.   CARDIOVASCULAR RESEARCH

Epidemiology of symptomatic drug-induced long QT syndrome and torsade de pointes in Germany

(2013) G. Sarganas et al.   EUROPACE

Transmural Dispersion of Repolarization as a Preclinical Marker of Drug-induced Proarrhythmia

(2012) Tamer H. Said et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk

(2011) Gary R. Mirams et al.   CARDIOVASCULAR RESEARCH

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

(2011) Thomas O'Hara et al.   PLoS Computational Biology

Early afterdepolarizations and cardiac arrhythmias

(2010) James N. Weiss et al.   HEART RHYTHM

Oscillations of cardiac wave length and proarrhythmia

(2010) L. M. Hondeghem et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The thorough QT/QTc study 4 years after the implementation of the ICH E14 guidance

(2009) B Darpo   BRITISH JOURNAL OF PHARMACOLOGY

International Life Sciences Institute (Health and Environmental Sciences Institute, HESI) initiative on moving towards better predictors of drug-induced torsades de pointes

(2008) A S Bass et al.   BRITISH JOURNAL OF PHARMACOLOGY

Clinical characteristics of patients with drug-induced QT interval prolongation and torsade de pointes: identification of risk factors

(2008) Konstantinos P. Letsas et al.   Clinical Research in Cardiology