High Level of Uric Acid Promotes Atherosclerosis by Targeting NRF2-Mediated Autophagy Dysfunction and Ferroptosis

Cellular degradation systems in ferroptosis

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Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects

(2021) Wen-Qi Ma et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ferroptosis and cardiovascular disease: role of free radical-induced lipid peroxidation

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Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway

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ELAVL1 is transcriptionally activated by FOXC1 and promotes ferroptosis in myocardial ischemia/reperfusion injury by regulating autophagy

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Autophagy is required for proper cysteine homeostasis in pancreatic cancer through regulation of SLC7A11

(2021) Subhadip Mukhopadhyay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High uric acid induces liver fat accumulation via ROS/JNK/AP-1 signaling

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Macrophage SR-BI modulates autophagy via VPS34 complex and PPARα transcription of Tfeb in atherosclerosis

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Autophagy blockage promotes the pyroptosis of ox-LDL-treated macrophages by modulating the p62/Nrf2/ARE axis

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Ferritinophagy and ferroptosis in the management of metabolic diseases

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GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis

(2021) Qiujie Wang et al.   Cell Death & Disease

Ferritinophagy and ferroptosis in cardiovascular disease: Mechanisms and potential applications

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Verification of ferroptosis and pyroptosis and identification of PTGS2 as the hub gene in human coronary artery atherosclerosis

(2021) Yaqing Zhou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Etomidate Attenuates the Ferroptosis in Myocardial Ischemia/Reperfusion Rat Model Via Nrf2 Pathway

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Ferroptosis: the potential value target in atherosclerosis

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Efficacy and Safety of Text Messages Targeting Adherence to Cardiovascular Medications in Secondary Prevention: TXT2HEART Colombia Randomized Controlled Trial

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Kaempferol Ameliorates Oxygen-Glucose Deprivation/Reoxygenation-Induced Neuronal Ferroptosis by Activating Nrf2/SLC7A11/GPX4 Axis

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Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases

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Serum Uric Acid Revealed a U-Shaped Relationship With All-Cause Mortality and Cardiovascular Mortality in High Atherosclerosis Risk Patients: The ASSURE Study

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The Link Between Ferroptosis and Cardiovascular Diseases: A Novel Target for Treatment

(2021) Huilin Hu et al.   Frontiers in Cardiovascular Medicine

Tanshinone IIA protects human coronary artery endothelial cells from ferroptosis by activating the NRF2 pathway

(2021) Lina He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Melatonin protects against PM2.5-induced lung injury by inhibiting ferroptosis of lung epithelial cells in a Nrf2-dependent manner

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Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation

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Lysine oxidase exposes a dependency on the thioredoxin antioxidant pathway in triple-negative breast cancer cells

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Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell

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Ferroptotic Cell Death: New Regulatory Mechanisms for Metabolic Diseases

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Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity

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Vitamin D3-VDR-PTPN6 axis mediated autophagy contributes to the inhibition of macrophage foam cell formation

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Ferroptosis: machinery and regulation

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Nrf2 and STAT3 Alleviates Ferroptosis-Mediated IIR-ALI by Regulating SLC7A11

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Nitro-oleic acid, a ligand of CD36, reduces cholesterol accumulation by modulating oxidized-LDL uptake and cholesterol efflux in RAW264.7 macrophages

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Sociodemographic Disparities in Influenza Vaccination Among Adults With Atherosclerotic Cardiovascular Disease in the United States

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The Metabolic Underpinnings of Ferroptosis

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Ferroptosis: molecular mechanisms and health implications

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High uric acid promotes dysfunction in pancreatic β cells by blocking IRS2/AKT signalling

(2020) Yaqiu Hu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Uric Acid and Cardiovascular Disease: An Update From Molecular Mechanism to Clinical Perspective

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NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

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Ferroptosis as a target for protection against cardiomyopathy

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Uricase and Horseradish Peroxidase Hybrid CaHPO4 Nanoflower Integrated with Transcutaneous Patches for Treatment of Hyperuricemia

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Macrophage Death as a Pharmacological Target in Atherosclerosis

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The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

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Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes

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Heme oxygenase-1 mediates BAY 11–7085 induced ferroptosis

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Elevated serum uric acid increases risks for developing high LDL cholesterol and hypertriglyceridemia: A five-year cohort study in Japan

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Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells

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The autophagy receptor SQSTM1/p62 mediates anti-inflammatory actions of the selective NR3C1/glucocorticoid receptor modulator compound A (CpdA) in macrophages

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Nrf2 Activation Provides Atheroprotection in Diabetic Mice Through Concerted Upregulation of Antioxidant, Anti-inflammatory, and Autophagy Mechanisms

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Hyperuricemia and endothelial function: From molecular background to clinical perspectives

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Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

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SIRT6 reduces macrophage foam cell formation by inducing autophagy and cholesterol efflux under ox-LDL condition

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Unexpected effect of urate on hydrogen peroxide-induced oxidative damage in embryonic chicken cardiac cells

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Asymptomatic Hyperuricemia Without Comorbidities Predicts Cardiometabolic DiseasesNovelty and Significance

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Uric Acid Is a Strong Risk Marker for Developing Hypertension From PrehypertensionNovelty and Significance

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NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression

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“Metabolically Healthy” Obesity and Hyperuricemia Increase Risk for Hypertension and Diabetes: 5-year Japanese Cohort Study

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Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis

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Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

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Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis

(2017) Jong-Lyel Roh et al.   Redox Biology

Transcriptional Regulation by Nrf2

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Elevated serum uric acid and risk of cardiovascular or all-cause mortality in people with suspected or definite coronary artery disease: A meta-analysis

(2016) Ruijuan Wang et al.   ATHEROSCLEROSIS

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Mst1 participates in the atherosclerosis progression through macrophage autophagy inhibition and macrophage apoptosis enhancement

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Hyperuricemia and the risk for coronary heart disease morbidity and mortality a systematic review and dose-response meta-analysis

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Serum uric acid is associated with mortality and heart failure hospitalizations in patients with complicated myocardial infarction: findings from the High-Risk Myocardial Infarction Database Initiative

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p62 links autophagy and Nrf2 signaling

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Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Prevalence of Hyperuricemia and Gout in Mainland China from 2000 to 2014: A Systematic Review and Meta-Analysis

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Oxidative stress and autophagy: the clash between damage and metabolic needs

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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis

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Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice

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