Article
Cardiac & Cardiovascular Systems
Shiwani Mahajan, Gowtham R. Grandhi, Javier Valero-Elizondo, Reed Mszar, Rohan Khera, Isaac Acquah, Tamer Yahya, Salim S. Virani, Ron Blankstein, Michael J. Blaha, Miguel Cainzos-Achirica, Khurram Nasir
Summary: The study found that about 1 in 7 American adults with ASCVD experience food insecurity, with more than 1 in 2 adults reporting food insecurity among vulnerable sociodemographic subgroups. Individuals with ASCVD who are younger, female, non-Hispanic Black or Hispanic, have private or no insurance, divorced/widowed/separated, and have low family income are more likely to be food insecure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Medicine, General & Internal
Kaja Z. LeWinn, Leonardo Trasande, Andrew Law, Courtney K. Blackwell, Traci A. Bekelman, Jessica A. Arizaga, Alexis A. Sullivan, Theresa M. Bastain, Carrie V. Breton, Margaret R. Karagas, Amy J. Elliott, Catherine J. Karr, Kecia N. Carroll, Anne L. Dunlop, Lisa A. Croen, Amy E. Margolis, Akram N. Alshawabkeh, Jose F. Cordero, Anne Marie Singh, Christine M. Seroogy, Daniel J. Jackson, Robert A. Wood, Tina V. Hartert, Young Shin Kim, Cristiane S. Duarte, Julie B. Schweitzer, Barry M. Lester, Cynthia T. Mcevoy, Thomas G. O'Connor, Emily Oken, Nicole Bornkamp, Eric D. Brown, Christina A. Porucznik, Assiamira Ferrara, Carlos A. Camargo, Qi Zhao, Jody M. Ganiban, Lisa P. Jacobson
Summary: The findings of this cohort study of US families reveal that families with lower socioeconomic status and young children faced more burdens during the pandemic. Recovery efforts and future planning should prioritize populations that are more vulnerable to public health crises.
Article
Immunology
Peng-jun Lu, Anup Srivastav, Kushagra Vashist, Carla L. Black, Jennifer L. Kriss, Mei-Chuan Hung, Lu Meng, Tianyi Zhou, David Yankey, Nina B. Masters, Hannah E. Fast, Hilda Razzaghi, James A. Singleton
Summary: The CDC recommends a COVID-19 vaccine booster dose for all adults >18 years of age. Analysis of data from the National Immunization Survey-Adult COVID Module showed that booster dose coverage among fully vaccinated adults increased from 25.7% in November 2021 to 63.4% in March 2022. Disparities in coverage were observed among different racial/ethnic groups and other factors. Tailored strategies are needed to educate the public and reduce disparities in COVID-19 vaccination coverage.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Immunology
Morgan Gurel-Headley, Mariam Mamisashvili, Sheena CarlLee, Sharon Reece, Christina Chapman, Shashank Kraleti, Jennifer A. A. Andersen, James P. P. Selig, Don E. E. Willis, Ji Li, Pearl A. A. McElfish
Summary: This study investigates the relationship between influenza vaccination and healthcare access, as well as the impact of discrimination on vaccine uptake. The study finds that age, race/ethnicity, education, healthcare coverage, primary care provider, forgoing medical care due to cost, and routine doctor checkups are significant factors influencing 5-year influenza vaccination rates. In contrast to previous studies, discrimination scores do not significantly correlate with regular influenza vaccination. Respondents who cannot afford medical care are less likely to report vaccination every year, indicating a complex association between affordability and influenza vaccination. Future research should focus on examining the relationship between influenza vaccination uptake, racial discrimination, and forgoing care due to cost to improve vaccination resources and messaging.
Article
Oncology
Javier Valero-Elizondo, Fouad Chouairi, Rohan Khera, Gowtham R. Grandhi, Anshul Saxena, Haider J. Warraich, Salim S. Virani, Nihar R. Desai, Farzan Sasangohar, Harlan M. Krumholz, Nestor F. Esnaola, Khurram Nasir
Summary: Financial toxicity (FT) is more prevalent among patients with ASCVD compared to those with cancer, with the highest burden observed in individuals with both conditions.
JACC: CARDIOONCOLOGY
(2021)
Article
Health Care Sciences & Services
Nell J. Marshall, Jennifer L. Lee, Jessica Schroeder, Wei-Nchih Lee, Jermyn See, Mohammad Madjid, Mrudula R. Munagala, John D. Piette, Litjen Tan, Orly Vardeny, Michael Greenberg, Jan Liska, Monica Mercer, Sandrine Samson
Summary: This personalized, evidence-based digital intervention proved effective in increasing vaccination rates among individuals with high-risk cardiovascular diseases. White and Asian individuals were more likely to get vaccinated, while the intervention had less impact on people of color.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Bhav Jain, Joseph Alexander Paguio, Jasper Seth Yao, Urvish Jain, Edward Christopher Dee, Leo Anthony Celi, Bisola Ojikutu
Summary: The study shows that there are variations in the rates of influenza vaccination among adults in different areas of the United States, with higher rates in urban areas. Regardless of age, gender, and race, the influenza vaccination rates exhibit a declining trend from large metropolitan areas to rural areas.
AMERICAN JOURNAL OF PUBLIC HEALTH
(2022)
Article
Immunology
Anup Srivastav, Peng-jun Lu, Ashley Amaya, Jill A. Dever, Marshica Stanley, Jessica L. Franks, Paul J. Scanlon, Allison M. Fisher, Stacie M. Greby, Kimberly H. Nguyen, Carla L. Black
Summary: This study investigated the prevalence of vaccine hesitancy among adults regarding influenza vaccination and examined the association between hesitancy beliefs and sociodemographic factors as well as early-season vaccination. The results showed that 40% of adults in the United States were hesitant to receive an influenza vaccination, and hesitancy was negatively correlated with vaccination rate. These findings are important for implementing targeted interventions to improve influenza vaccination coverage.
Article
Immunology
Joseph Alexander Paguio, Bisola O. Ojikutu, Pia Gabrielle Alfonso, Jasper Seth Yao, Troy B. Amen, Edward Christopher Dee, Gerome Escota
Summary: This study explores the association between self-reported measures of culturally competent care and influenza vaccination rates in the United States. The findings suggest that individuals who experience culturally competent care, characterized by respect, clear communication, and cultural understanding, are more likely to receive the annual influenza vaccine. The study highlights the importance of evaluating vaccination outcomes among patients who receive culturally competent care.
Article
Medicine, General & Internal
Jiang-Shui Wang, Peng-Fei Xia, Meng-Nan Ma, Yue Li, Ting-Ting Geng, Yan-Bo Zhang, Zhou-Zheng Tu, Limiao Jiang, Li-Rong Zhou, Bing-Fei Zhang, Wen-Wei Tong, Zhilei Shan, Gang Liu, Kun Yang, An Pan
Summary: Understanding the trends in the prevalence of metabolically healthy obesity (MHO) among US adults from 1999 to 2018 can help with stratification and management of obesity and inform policy efforts.
Article
Immunology
Brandon M. Imp, Tory Levine, Derek D. Satre, Jacek Skarbinski, Mitchell N. Luu, Stacy A. Sterling, Michael J. Silverberg
Summary: In this study, it was found that people living with HIV (PWH) had a nearly 50% higher uptake of influenza vaccination compared to people without HIV (PWoH) in Kaiser Permanente Northern California. Factors associated with lower vaccination rates were also identified, particularly among PWH with more complex health needs. These findings may inform outreach strategies to increase influenza vaccination in PWH.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Health Care Sciences & Services
Matthew T. Mefford, Ran Liu, Katia Bruxvoort, Lei Qian, Jonathan M. Doris, Sandra Y. Koyama, Hung Fu Tseng, Kristi Reynolds
Summary: The study found that influenza vaccination in heart failure patients was associated with a lower risk of mortality and cardiovascular mortality during the influenza season, but a higher risk of hospitalization. There was no significant association between influenza vaccination and all-cause mortality during the non-influenza season.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Matthew F. Daley, Liza M. Reifler, Jo Ann Shoup, Jason M. Glanz, Allison L. Naleway, Jennifer C. Nelson, Joshua T. B. Williams, Huong Q. Mclean, Gabriela Vazquez-Benitez, Kristin Goddard, Bruno J. Lewin, Eric S. Weintraub, Michael M. Mcneil, Hilda Razzaghi, James A. Singleton
Summary: This study assessed the contribution of vaccine-related attitudes to racial and ethnic disparities in influenza vaccination coverage among pregnant women in the United States. The results showed that vaccine-related attitudes played a significant role in the observed differences among racial and ethnic groups.
PREVENTIVE MEDICINE
(2023)
Article
Critical Care Medicine
Jennifer Richmond, Megan Hollister Murray, Cato M. Milder, Jeffrey D. Blume, Melinda C. Aldrich
Summary: This study identified factors contributing to racial disparities in lung cancer stage of diagnosis among low-income adults. Individual-level and area-level factors were found to be associated with distant stage diagnosis. The predictive power of the model slightly improved when psychosocial factors were considered. Interventions on both structural and individual-level factors are necessary to reduce racial disparities in lung cancer stage at presentation.
Article
Medicine, General & Internal
Erica Kornblith, Amber Bahorik, John Boscardin, Feng Xia, Deborah E. Barnes, Kristine Yaffe
Summary: This study investigated dementia incidence among older veterans in the US based on race and ethnicity, revealing significant differences in dementia rates among different racial and ethnic groups. The findings suggest a need for further research to understand the underlying mechanisms responsible for these disparities.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Editorial Material
Medicine, General & Internal
Carlos del Rio, Saad B. Omer, Preeti N. Malani
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Virology
Nusrat Homaira, Michael Binks, Gregory Walker, Natasha Larter, Katrina Clark, Megan Campbell, Lisa McHugh, Nancy Briggs, Joyce Nyiro, Sacha Stelzer-Braid, Nan Hu, Kristine Macartney, Tom Snelling, Saad B. Omer, William Rawlinson, Ross Andrews, Adam Jaffe
Summary: This study investigated the transfer of RSV antibodies from Australian First Nations mothers to infants, finding that one-third of the pairs had impaired transfer of antibodies. The majority of infants were born full term, with 56% being male, and the levels of RSV antibodies in maternal and cord blood were similar.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eddy Perez-Then, Carolina Lucas, Valter Silva Monteiro, Marija Miric, Vivian Brache, Leila Cochon, Chantal B. F. Vogels, Amyn A. Malik, Elena De la Cruz, Aidelis Jorge, Margarita De los Santos, Patricia Leon, Mallery Breban, Kendall Billig, Inci Yildirim, Claire Pearson, Randy Downing, Emily Gagnon, Anthony Muyombwe, Jafar Razeq, Melissa Campbell, Albert Ko, Saad B. Omer, Nathan D. Grubaugh, Sten H. Vermund, Akiko Iwasaki
Summary: The study found that a BNT162b2 mRNA vaccine booster can enhance neutralizing antibodies against the Omicron variant in individuals who received two doses of the CoronaVac vaccine, but antibody titers remain lower compared to the ancestral virus and the Delta variant.
Review
Psychology, Developmental
Jad A. Elharake, Faris Akbar, Amyn A. Malik, Walter Gilliam, Saad B. Omer
Summary: The COVID-19 pandemic has significantly impacted the mental health of children and college students, leading to increased anxiety, depression, fatigue, and distress. Factors such as living in rural areas, low family socioeconomic status, and having a connection to healthcare workers have been associated with worse mental health outcomes. Future strategies should prioritize social contacts to support students at higher risk of social isolation during the pandemic.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2023)
Article
Immunology
Kavin M. Patel, Mehr Shafiq, Amyn A. Malik, Ayse Cobanoglu, Madeline Klotz, John Eric Humphries, Aiden Lee, Thomas Murray, David Wilkinson, Inci Yildirim, Jad A. Elharake, Rachel Diaz, Rosalia Rojas, Anael Kuperwajs Cohen, Saad B. Omer, Walter S. Gilliam
Summary: Child care providers who did not receive the COVID-19 vaccine were also less likely to use nonpharmaceutical interventions. Mandatory vaccination may be necessary for pandemic control.
Article
Biochemistry & Molecular Biology
Alice Lu-Culligan, Alexandra Tabachnikova, Eddy Perez-Then, Maria Tokuyama, Hannah J. Lee, Carolina Lucas, Valter Silva Monteiro, Marija Miric, Vivian Brache, Leila Cochon, M. Catherine Muenker, Subhasis Mohanty, Jiefang Huang, Insoo Kang, Charles Dela Cruz, Shelli Farhadian, Melissa Campbell, Inci Yildirim, Albert C. Shaw, Shuangge Ma, Sten H. Vermund, Albert Ko, Saad B. Omer, Akiko Iwasaki
Summary: This study found that COVID-19 mRNA vaccination during early pregnancy does not lead to birth defects or growth abnormalities in mice, and does not cause overt maternal illness. Furthermore, it was observed that there is transplacental transfer of antibodies in the later stages of pregnancy after early immunization. Additionally, no increased levels of anti-syncytin-1 antibodies were detected in vaccinated adults.
Editorial Material
Medicine, General & Internal
Douglas J. Opel, Noel T. Brewer, Alison M. Buttenheim, Timothy Callaghan, Richard M. Carpiano, Chelsea Clinton, Jad A. Elharake, Lisa C. Flowers, Alison P. Galvani, Peter J. Hotez, Jason L. Schwartz, Regina M. Benjamin, Arthur Caplan, Renee DiResta, Rekha Lakshmanan, Yvonne A. Maldonado, Michelle M. Mello, Wendy E. Parmet, Daniel A. Salmon, Joshua M. Sharfstein, Saad B. Omer
Article
Multidisciplinary Sciences
Maike Winters, Amyn A. Malik, Saad B. Omer
Summary: Amidst an unprecedented Monkeypox outbreak, a study was conducted to measure knowledge, attitudes, practices, and vaccination intentions among the U.S. adult population. The results revealed low levels of self-assessed knowledge, vaccination intentions, and the influence of COVID-19 vaccination status, indicating a lack of clear communication.
Article
Immunology
Matthew Z. Dudley, Erin E. Barnett, Alex Paulenich, Saad B. Omer, Holly Schuh, Tina M. Proveaux, Alison M. Buttenheim, Nicola P. Klein, Paul Delamater, SarahAnn M. McFadden, Kavin M. Patel, Daniel A. Salmon
Summary: In October 2021, Emergency Use Authorization was granted for COVID-19 vaccines for children aged 5-11. California plans to mandate COVID-19 vaccination for school children once the vaccines receive full FDA approval. A survey conducted in California found that 26% of parents did not intend to vaccinate their child against COVID-19, indicating skepticism and potential pushback. However, 17% of parents were unsure, suggesting that public health messaging could influence vaccine confidence and uptake. Research and outreach efforts should target hesitant parents.
Article
Evolutionary Biology
Mary E. Petrone, Carolina Lucas, Bridget Menasche, Mallery Breban, Inci Yildirim, Melissa Campbell, Saad B. Omer, Edward C. Holmes, Albert Ko, Nathan D. Grubaugh, Akiko Iwasaki, Craig B. Wilen, Chantal B. F. Vogels, Joseph R. Fauver
Summary: Developing a timely and effective response to emerging SARS-CoV-2 variants of concern is crucial for public health. Global health surveillance relies not only on genomic data but also on methods that utilize genomic data to estimate the epidemiological dynamics of emerging lineages. In this study, the differences in reporting delays among SARS-CoV-2 VOCs were analyzed, indicating that these delays may have delayed the global response to the Mu variant. The nonsystematic biases in the reporting of genomic data could impede the assessment of future emerging variants.
GENOME BIOLOGY AND EVOLUTION
(2023)
Article
Immunology
Adeel A. Butt, Peng Yan, Obaid S. Shaikh, Saad B. Omer, Florian B. Mayr, Victor B. Talisa
Summary: In previously uninfected, nonhospitalized, high-risk persons with COVID-19, the use of molnupiravir does not significantly reduce the rate of hospitalization or death within 30 days of diagnosis. However, asymptomatic patients might experience a benefit.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Editorial Material
Medicine, General & Internal
Richard M. Carpiano, Timothy Callaghan, Renee DiResta, Noel Brewer, Chelsea Clinton, Alison P. Galvani, Rekha Lakshmanan, Wendy E. Parmet, Saad B. Omer, Alison M. Buttenheim, Regina M. Benjamin, Arthur Caplan, Jad A. Elharake, Lisa C. Flowers, Yvonne A. Maldonado, Michelle M. Mello, Douglas J. Opel, Daniel A. Salmon, Jason L. Schwartz, Joshua M. Sharfstein, Peter J. Hotez
Article
Cell Biology
Bruno Andraus Filardi, Valter Silva Monteiro, Pedro Vellosa Schwartzmann, Vivian do Prado Martins, Luis Eduardo Rosa Zucca, Gabriela Crispim Baiocchi, Amyn A. Malik, Julio Silva, Anne M. Hahn, Nicholas F. G. Chen, Kien Pham, Eddy Perez-Then, Marija Miric, Vivian Brache, Leila Cochon, Rafael A. Larocca, Roberto Della Rosa Mendez, Douglas Bardini Silveira, Aguinaldo Roberto Pinto, Julio Croda, Inci Yildirim, Saad B. Omer, Albert I. Ko, Sten H. Vermund, Nathan D. Grubaugh, Akiko Iwasaki, Carolina Lucas
Summary: The emergence of the SARS-CoV-2 Omicron sublineages resulted in increased transmission rates and reduced vaccine protection. Homologous CoronaVac booster doses showed lower efficiency in enhancing immune response compared to heterologous BNT162b2 or ChAdOx1 boosters, especially in individuals over 50 years old. These findings emphasize the potential benefits of heterologous vaccination strategies for older adults fully vaccinated with CoronaVac during the Omicron wave.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Anis Barmada, Jon Klein, Anjali Ramaswamy, Nina N. Brodsky, Jillian R. Jaycox, Hassan Sheikha, Kate M. Jones, Victoria Habet, Melissa Campbell, Tomokazu S. Sumida, Amy Kontorovich, Dusan Bogunovic, Carlos R. Oliveira, Jeremy Steele, E. Kevin Hall, Mario Pena-Hernandez, Valter Monteiro, Carolina Lucas, Aaron M. Ring, Saad B. Omer, Akiko Iwasaki, Inci Yildirim, Carrie L. Lucas
Summary: A study found that rare immune-mediated cardiac tissue inflammation can occur after SARS-CoV-2 mRNA vaccination. Contrary to early hypotheses, the underlying mechanisms of this pathology do not involve hypersensitivity myocarditis or hyperimmune humoral response. Instead, elevated levels of inflammatory cytokines, chemokines, and matrix metalloproteases were observed, along with expansion of activated T cells and NK cells, and inflammation and fibrosis in monocytes. These findings provide insights into the cytokine-dependent pathology of vaccine-associated myopericarditis and have implications for vaccine development and clinical care.
SCIENCE IMMUNOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Nour J. Youssef, Nadim K. Tfaily, Mohammad Bahij M. Moumneh, Celina F. Boutros, Jad A. Elharake, Amyn A. Malik, SarahAnn M. McFadden, Bayan Galal, Inci Yildirim, Kaveh Khoshnood, Saad B. Omer, Ziad A. Memish, Ghassan S. Dbaibo
Summary: Lebanese healthcare workers show relatively high acceptance of the COVID-19 vaccine, but there are still barriers such as concerns about insufficient research. The WHO and healthcare providers are the most trusted sources of COVID-19 information. These findings are important for informing Lebanese health authorities in improving vaccine uptake.
JOURNAL OF EPIDEMIOLOGY AND GLOBAL HEALTH
(2023)