High uric acid promotes dysfunction in pancreatic β cells by blocking IRS2/AKT signalling

Serum uric acid levels and cardiovascular mortality in a general Japanese population: the Hisayama Study

(2020) Satoko Sakata et al.   HYPERTENSION RESEARCH

Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells

(2019) Elizabeth Haythorne et al.   Nature Communications

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

(2019) Daehwan Kim et al.   NATURE BIOTECHNOLOGY

High Uric Acid Inhibits Cardiomyocyte Viability Through the ERK/P38 Pathway via Oxidative Stress

(2018) Zhi Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Knockout of the urate oxidase gene provides a stable mouse model of hyperuricemia associated with metabolic disorders

(2018) Jie Lu et al.   KIDNEY INTERNATIONAL

The association between elevated serum uric acid levels and islet β-cell function indexes in newly diagnosed type 2 diabetes mellitus: a cross-sectional study

(2018) Yimeng Hu et al.   PeerJ

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Metformin ameliorates high uric acid-induced insulin resistance in skeletal muscle cells

(2017) Huier Yuan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Uric acid increases cellular and humoral alloimmunity in primary human peripheral blood mononuclear cells

(2017) Theodoros Eleftheriadis et al.   NEPHROLOGY

Soluble Uric Acid Activates the NLRP3 Inflammasome

(2017) Tarcio Teodoro Braga et al.   Scientific Reports

Beta-cell mitochondrial carriers and the diabetogenic stress response

(2016) Thierry Brun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

High Uric Acid Activates the ROS-AMPK Pathway, Impairs CD68 Expression and Inhibits OxLDL-Induced Foam-Cell Formation in a Human Monocytic Cell Line, THP-1

(2016) Chaohuan Luo et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease

(2016) Laetitia Koppe et al.   JOURNAL OF CLINICAL INVESTIGATION

High serum uric acid levels increase the risk of metabolic syndrome in elderly women: The PRO.V.A study

(2016) A. Zurlo et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

High uric acid directly inhibits insulin signalling and induces insulin resistance

(2014) Yuzhang Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense

(2014) Y Itahana et al.   ONCOGENE

Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9

(2014) Brian J DeBosch et al.   Nature Communications

The Association between Serum Uric Acid and Residualβ-Cell Function in Type 2 Diabetes

(2014) Wei Tang et al.   Journal of Diabetes Research

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Metabolic Signaling in Fuel-Induced Insulin Secretion

(2013) Marc Prentki et al.   Cell Metabolism

Uric acid transporter ABCG2 is increased in the intestine of the 5/6 nephrectomy rat model of chronic kidney disease

(2013) Hirofumi Yano et al.   Clinical and Experimental Nephrology

Sugar, Uric Acid, and the Etiology of Diabetes and Obesity

(2013) R. J. Johnson et al.   DIABETES

Uric acid induces oxidative stress and growth inhibition by activating adenosine monophosphate-activated protein kinase and extracellular signal-regulated kinase signal pathways in pancreatic β cells

(2013) Yongneng Zhang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Hyperuricemia Causes Pancreatic β-Cell Death and Dysfunction through NF-κB Signaling Pathway

(2013) Lu Jia et al.   PLoS One

Diabetes Mellitus and the β Cell: The Last Ten Years

(2012) Frances M. Ashcroft et al.   CELL

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Protective effects of cortex fraxini coumarines against oxonate-induced hyperuricemia and renal dysfunction in mice

(2011) Jian-Mei Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

High serum uric acid level and low urine pH as predictors of metabolic syndrome: a retrospective cohort study in a Japanese urban population

(2011) Shigeko Hara et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Pro-inflammatory and oxidative effects of noncrystalline uric acid in human mesangial cells: contribution to hyperuricemic glomerular damage

(2010) M. S. Convento et al.   UROLOGICAL RESEARCH

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Association Between Serum Uric Acid and Development of Type 2 Diabetes

(2009) S. Kodama et al.   DIABETES CARE

Genetic and biochemical pathways of β-cell failure in type 2 diabetes

(2009) C. Talchai et al.   DIABETES OBESITY & METABOLISM