Ion flux-independent NMDA receptor signaling

Non-ionotropic NMDA receptor signaling gates bidirectional structural plasticity of dendritic spines

(2021) Ivar S. Stein et al.   Cell Reports

Conformational rearrangement of the NMDA receptor amino-terminal domain during activation and allosteric modulation

(2021) Vojtech Vyklicky et al.   Nature Communications

The role of NMDA receptor and neuroligin rare variants in synaptic dysfunction underlying neurodevelopmental disorders

(2021) Marta Mota Vieira et al.   CURRENT OPINION IN NEUROBIOLOGY

PSD-95 protects synapses from β-amyloid

(2021) Kim Dore et al.   Cell Reports

NMDA receptors elicit flux-independent intracellular Ca2+ signals via metabotropic glutamate receptors and flux-dependent nitric oxide release in human brain microvascular endothelial cells

(2021) Sharon Negri et al.   CELL CALCIUM

Nonionotropic Action of Endothelial NMDA Receptors on Blood–Brain Barrier Permeability via Rho/ROCK-Mediated Phosphorylation of Myosin

(2020) Anupriya Mehra et al.   JOURNAL OF NEUROSCIENCE

Elevated PSD-95 Blocks Ion-flux Independent LTD: A Potential New Role for PSD-95 in Synaptic Plasticity

(2020) Kim Dore et al.   NEUROSCIENCE

Tripartite signalling by NMDA receptors

(2020) Vishaal Rajani et al.   Molecular Brain

The C‐terminal domains of the NMDA receptor: How intrinsically disordered tails affect signalling, plasticity, and disease

(2020) Xavier L. Warnet et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Molecular Mechanisms of Non-ionotropic NMDA Receptor Signaling in Dendritic Spine Shrinkage

(2020) Ivar S. Stein et al.   JOURNAL OF NEUROSCIENCE

Architecture and function of NMDA receptors: an evolutionary perspective

(2020) David Stroebel et al.   JOURNAL OF PHYSIOLOGY-LONDON

Dissociation of functional and structural plasticity of dendritic spines during NMDAR and mGluR-dependent long-term synaptic depression in wild-type and fragile X model mice

(2020) Aurore Thomazeau et al.   MOLECULAR PSYCHIATRY

Superoxide and Non-ionotropic Signaling in Neuronal Excitotoxicity

(2020) Jiejie Wang et al.   Frontiers in Neuroscience

Regulation of membrane NMDA receptors by dynamics and protein interactions

(2020) Mar Petit-Pedrol et al.   JOURNAL OF CELL BIOLOGY

Targeting the Synapse in Alzheimer’s Disease

(2019) Johanna Jackson et al.   Frontiers in Neuroscience

The origin of NMDA receptor hypofunction in schizophrenia

(2019) Kazu Nakazawa et al.   PHARMACOLOGY & THERAPEUTICS

Ion occupancy of the channel pore is critical for triggering excitation-transcription (ET) coupling

(2019) Evrim Servili et al.   CELL CALCIUM

Suppression of Presynaptic Glutamate Release by Postsynaptic Metabotropic NMDA Receptor Signalling to Pannexin-1

(2019) Jennifer Bialecki et al.   JOURNAL OF NEUROSCIENCE

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

(2018) Steven J. Forrester et al.   CIRCULATION RESEARCH

Long-Term Depression Is Independent of GluN2 Subunit Composition

(2018) Jonathan M. Wong et al.   JOURNAL OF NEUROSCIENCE

Dendritic Spine Elimination: Molecular Mechanisms and Implications

(2018) Ivar S. Stein et al.   NEUROSCIENTIST

Excitotoxic superoxide production and neuronal death require both ionotropic and non-ionotropic NMDA receptor signaling

(2018) Angela M. Minnella et al.   Scientific Reports

NMDA receptors: linking physiological output to biophysical operation

(2017) Gary J. Iacobucci et al.   NATURE REVIEWS NEUROSCIENCE

Differential Regulation of Evoked and Spontaneous Release by Presynaptic NMDA Receptors

(2017) Therése Abrahamsson et al.   NEURON

Modulating synaptic NMDA receptors

(2017) Kenneth R. Tovar et al.   NEUROPHARMACOLOGY

A non-ionotropic activity of NMDA receptors contributes to glycine-induced neuroprotection in cerebral ischemia-reperfusion injury

(2017) Juan Chen et al.   Scientific Reports

Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology

(2017) Kevin K. Ogden et al.   PLoS Genetics

Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses

(2017) Joana S Ferreira et al.   eLife

Postsynaptic, not presynaptic NMDA receptors are required for spike-timing-dependent LTD induction

(2016) Brett C Carter et al.   NATURE NEUROSCIENCE

Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity

(2016) Nicholas L Weilinger et al.   NATURE NEUROSCIENCE

Emerging roles of GluN3-containing NMDA receptors in the CNS

(2016) Isabel Pérez-Otaño et al.   NATURE REVIEWS NEUROSCIENCE

Non-canonical Signaling, the Hidden Life of Ligand-Gated Ion Channels

(2016) Sergio Valbuena et al.   NEURON

NMDA Receptor-Dependent LTD Requires Transient Synaptic Incorporation of Ca 2+ -Permeable AMPARs Mediated by AKAP150-Anchored PKA and Calcineurin

(2016) Jennifer L. Sanderson et al.   NEURON

Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression

(2016) B. Li et al.   SCIENCE

Tissue-type plasminogen activator controls neuronal death by raising surface dynamics of extrasynaptic NMDA receptors

(2016) Flavie Lesept et al.   Cell Death & Disease

Glycine Potentiates AMPA Receptor Function through Metabotropic Activation of GluN2A-Containing NMDA Receptors

(2016) Li-Jun Li et al.   Frontiers in Molecular Neuroscience

NMDA receptor subunit mutations in neurodevelopmental disorders

(2015) Nail Burnashev et al.   CURRENT OPINION IN PHARMACOLOGY

Dynamic Regulation ofN-Methyl-d-aspartate (NMDA) and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors by Posttranslational Modifications

(2015) Marc P. Lussier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-Ionotropic NMDA Receptor Signaling Drives Activity-Induced Dendritic Spine Shrinkage

(2015) I. S. Stein et al.   JOURNAL OF NEUROSCIENCE

In vivo magnetic resonance studies reveal neuroanatomical and neurochemical abnormalities in the serine racemase knockout mouse model of schizophrenia

(2015) Matthew D. Puhl et al.   NEUROBIOLOGY OF DISEASE

A Temporary Gating of Actin Remodeling during Synaptic Plasticity Consists of the Interplay between the Kinase and Structural Functions of CaMKII

(2015) Karam Kim et al.   NEURON

A Metabotropic-Like Flux-Independent NMDA Receptor Regulates Ca2+ Exit from Endoplasmic Reticulum and Mitochondrial Membrane Potential in Cultured Astrocytes

(2015) Pavel Montes de Oca Balderas et al.   PLoS One

Agonist binding to the NMDA receptor drives movement of its cytoplasmic domain without ion flow

(2015) Kim Dore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational signaling required for synaptic plasticity by the NMDA receptor complex

(2015) Jonathan Aow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss

(2015) J H Birnbaum et al.   Cell Death & Disease

Ionotropic NMDA Receptor Signaling Is Required for the Induction of Long-Term Depression in the Mouse Hippocampal CA1 Region

(2014) W. E. Babiec et al.   JOURNAL OF NEUROSCIENCE

CAPON-nNOS coupling can serve as a target for developing new anxiolytics

(2014) Li-Juan Zhu et al.   NATURE MEDICINE

Structural and Molecular Remodeling of Dendritic Spine Substructures during Long-Term Potentiation

(2014) Miquel Bosch et al.   NEURON

Autonomous CaMKII Mediates Both LTP and LTD Using a Mechanism for Differential Substrate Site Selection

(2014) Steven J. Coultrap et al.   Cell Reports

LTP-Induced Long-Term Stabilization of Individual Nascent Dendritic Spines

(2013) T. C. Hill et al.   JOURNAL OF NEUROSCIENCE

The nNOS-p38MAPK Pathway Is Mediated by NOS1AP during Neuronal Death

(2013) L.-L. Li et al.   JOURNAL OF NEUROSCIENCE

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

NMDA-Receptor Activation but Not Ion Flux Is Required for Amyloid-Beta Induced Synaptic Depression

(2013) Albert Tamburri et al.   PLoS One

Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression

(2013) S. Nabavi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabotropic NMDA receptor function is required for  -amyloid-induced synaptic depression

(2013) H. W. Kessels et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction

(2013) D. T. Balu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a single amino acid in GluN1 that is critical for glycine-primed internalization of NMDA receptors

(2013) Lu Han et al.   Molecular Brain

Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists

(2012) Thomas Papouin et al.   CELL

βCaMKII Regulates Actin Assembly and Structure

(2009) Hugo Sanabria et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of CaMKII in single dendritic spines during long-term potentiation

(2009) Seok-Jin R. Lee et al.   NATURE

Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior

(2008) A C Basu et al.   MOLECULAR PSYCHIATRY