NMDA receptors: linking physiological output to biophysical operation

Semiclosed Conformations of the Ligand-Binding Domains of NMDA Receptors during Stationary Gating

(2016) Jian Dai et al.   BIOPHYSICAL JOURNAL

Structural basis of kainate subtype glutamate receptor desensitization

(2016) Joel R. Meyerson et al.   NATURE

Activation of NMDA receptors and the mechanism of inhibition by ifenprodil

(2016) Nami Tajima et al.   NATURE

Emergence of ion channel modal gating from independent subunit kinetics

(2016) Brendan A. Bicknell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiological Roles of Non-Neuronal NMDA Receptors

(2016) Adam D. Hogan-Cann et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Conformational Transitions in the Glycine-Bound GluN1 NMDA Receptor LBD via Single-Molecule FRET

(2015) David R. Cooper et al.   BIOPHYSICAL JOURNAL

The NMDA receptor ‘glycine modulatory site’ in schizophrenia: d-serine, glycine, and beyond

(2015) Darrick T Balu et al.   CURRENT OPINION IN PHARMACOLOGY

Kinetic Contributions to Gating by Interactions Unique toN-methyl-d-aspartate (NMDA) Receptors

(2015) William F. Borschel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subtype-dependentN-Methyl-d-aspartate Receptor Amino-terminal Domain Conformations and Modulation by Spermine

(2015) Rita E. Sirrieh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A conserved structural mechanism of NMDA receptor inhibition: A comparison of ifenprodil and zinc

(2015) Rita E. Sirrieh et al.   JOURNAL OF GENERAL PHYSIOLOGY

Glycine-dependent activation of NMDA receptors

(2015) Kirstie A. Cummings et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structural dynamics of potassium-channel gating revealed by single-molecule FRET

(2015) Shizhen Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Presynaptic NMDA receptors: Roles and rules

(2015) G. Bouvier et al.   NEUROSCIENCE

Agonist binding to the NMDA receptor drives movement of its cytoplasmic domain without ion flow

(2015) Kim Dore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational signaling required for synaptic plasticity by the NMDA receptor complex

(2015) Jonathan Aow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural dynamics of potassium-channel gating revealed by single-molecule FRET

(2015) Shizhen Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Glutamate Receptor Antagonists as Fast-Acting Therapeutic Alternatives for the Treatment of Depression: Ketamine and Other Compounds

(2014) Mark J. Niciu et al.   Annual Review of Pharmacology and Toxicology

Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States

(2014) Katharina L. Dürr et al.   CELL

Separate Intramolecular Targets for Protein Kinase A ControlN-Methyl-d-aspartate Receptor Gating and Ca2+Permeability

(2014) Teresa K. Aman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Dynamics of the Glycine-binding Domain of theN-Methyl-d-Aspartate Receptor

(2014) Drew M. Dolino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular bases of NMDA receptor subtype-dependent properties

(2014) Nathan G. Glasgow et al.   JOURNAL OF PHYSIOLOGY-LONDON

Giant nonlinear response from plasmonic metasurfaces coupled to intersubband transitions

(2014) Jongwon Lee et al.   NATURE

Structural mechanism of glutamate receptor activation and desensitization

(2014) Joel R. Meyerson et al.   NATURE

Mechanical coupling maintains the fidelity of NMDA receptor–mediated currents

(2014) Rashek Kazi et al.   NATURE NEUROSCIENCE

Zinc Dynamics and Action at Excitatory Synapses

(2014) Angela Maria Vergnano et al.   NEURON

Distinct Functional and Pharmacological Properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA Receptors

(2014) Kasper B. Hansen et al.   NEURON

Crystal structure of a heterotetrameric NMDA receptor ion channel

(2014) E. Karakas et al.   SCIENCE

An NMDA Receptor Gating Mechanism Developed from MD Simulations Reveals Molecular Details Underlying Subunit-Specific Contributions

(2013) Jian Dai et al.   BIOPHYSICAL JOURNAL

Amino-terminal Domain Tetramer Organization and Structural Effects of Zinc Binding in theN-Methyl-d-aspartate (NMDA) Receptor

(2013) Rita E. Sirrieh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic and Structural Determinants of NMDA Receptor Voltage-Dependent Gating and Slow Mg2+ Unblock

(2013) R. J. Clarke et al.   JOURNAL OF NEUROSCIENCE

Asynchronous Movements Prior to Pore Opening in NMDA Receptors

(2013) R. Kazi et al.   JOURNAL OF NEUROSCIENCE

Triheteromeric NMDA Receptors at Hippocampal Synapses

(2013) K. R. Tovar et al.   JOURNAL OF NEUROSCIENCE

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Modal gating of GluN1/GluN2D NMDA receptors

(2013) Katie M. Vance et al.   NEUROPHARMACOLOGY

Conformational Analysis of NMDA Receptor GluN1, GluN2, and GluN3 Ligand-Binding Domains Reveals Subtype-Specific Characteristics

(2013) Yongneng Yao et al.   STRUCTURE

Mechanisms of glycine release, which build up synaptic and extrasynaptic glycine levels: The role of synaptic and non-synaptic glycine transporters

(2012) Laszlo G. Harsing et al.   BRAIN RESEARCH BULLETIN

Gating reaction mechanism of neuronal NMDA receptors

(2012) William F. Borschel et al.   JOURNAL OF NEUROPHYSIOLOGY

Opposing Roles of Synaptic and Extrasynaptic NMDA Receptor Signaling in Cocultured Striatal and Cortical Neurons

(2012) A. M. Kaufman et al.   JOURNAL OF NEUROSCIENCE

GluN1 splice variant control of GluN1/GluN2D NMDA receptors

(2012) Katie M. Vance et al.   JOURNAL OF PHYSIOLOGY-LONDON

A single GluN2 subunit residue controls NMDA receptor channel properties via intersubunit interaction

(2012) Beth Siegler Retchless et al.   NATURE NEUROSCIENCE

Synaptic Energy Use and Supply

(2012) Julia J. Harris et al.   NEURON

GluN3 subunit-containing NMDA receptors: not just one-trick ponies

(2012) Svenja Pachernegg et al.   TRENDS IN NEUROSCIENCES

Zinc Effects on NMDA Receptor Gating Kinetics

(2011) Stacy A. Amico-Ruvio et al.   BIOPHYSICAL JOURNAL

Conformational Changes at the Agonist Binding Domain of theN-Methyl-d-Aspartic Acid Receptor

(2011) Anu Rambhadran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit

(2011) Chihiro Nozaki et al.   NATURE NEUROSCIENCE

NMDA receptor activation requires remodelling of intersubunit contacts within ligand-binding heterodimers

(2011) William F. Borschel et al.   Nature Communications

Stationary Gating of GluN1/GluN2B Receptors in Intact Membrane Patches

(2010) Stacy A. Amico-Ruvio et al.   BIOPHYSICAL JOURNAL

Impaired Glial Glutamate Uptake Induces Extrasynaptic Glutamate Spillover in the Spinal Sensory Synapses of Neuropathic Rats

(2010) Hui Nie et al.   JOURNAL OF NEUROPHYSIOLOGY

NMDA Receptors with Locked Glutamate-Binding Clefts Open with High Efficacy

(2010) C. L. Kussius et al.   JOURNAL OF NEUROSCIENCE

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

Dynamic and specific interaction between synaptic NR2-NMDA receptor and PDZ proteins

(2010) L. Bard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-channel properties ofN-methyl-D-aspartate receptors containing chimaeric GluN2A/GluN2D subunits

(2009) Timothy O'Leary et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit

(2009) Erkan Karakas et al.   EMBO JOURNAL

Control of NMDA Receptor Function by the NR2 Subunit Amino-Terminal Domain

(2009) H. Yuan et al.   JOURNAL OF NEUROSCIENCE

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

(2009) Alexander I. Sobolevsky et al.   NATURE

Kinetic basis of partial agonism at NMDA receptors

(2009) Cassandra L Kussius et al.   NATURE NEUROSCIENCE

Zinc in the physiology and pathology of the CNS

(2009) Stefano L. Sensi et al.   NATURE REVIEWS NEUROSCIENCE

Rapid Functional Maturation of Nascent Dendritic Spines

(2009) Karen Zito et al.   NEURON

Neto1 Is a Novel CUB-Domain NMDA Receptor–Interacting Protein Required for Synaptic Plasticity and Learning

(2009) David Ng et al.   PLOS BIOLOGY

A quantitative method to assess extrasynaptic NMDA receptor function in the protective effect of synaptic activity against neurotoxicity

(2008) C Peter Bengtson et al.   BMC NEUROSCIENCE

Activation of recombinant NR1/NR2C NMDA receptors

(2008) Shashank M. Dravid et al.   JOURNAL OF PHYSIOLOGY-LONDON

Distinct gating modes determine the biphasic relaxation of NMDA receptor currents

(2008) Wei Zhang et al.   NATURE NEUROSCIENCE

Zinc inhibition of rat NR1/NR2AN-methyl-d-aspartate receptors

(2007) Kevin Erreger et al.   JOURNAL OF PHYSIOLOGY-LONDON