NMDA receptors elicit flux-independent intracellular Ca2+ signals via metabotropic glutamate receptors and flux-dependent nitric oxide release in human brain microvascular endothelial cells
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Title
NMDA receptors elicit flux-independent intracellular Ca2+ signals via metabotropic glutamate receptors and flux-dependent nitric oxide release in human brain microvascular endothelial cells
Authors
Keywords
NMDA receptors, Brain microvascular endothelial cells, Flux-dependent, Flux-independent, mGluRs, Ca, signaling
Journal
CELL CALCIUM
Volume 99, Issue -, Pages 102454
Publisher
Elsevier BV
Online
2021-08-17
DOI
10.1016/j.ceca.2021.102454
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Note: Only part of the references are listed.- Endothelial signaling at the core of neurovascular coupling: The emerging role of endothelial inward-rectifier K+ (Kir2.1) channels and N-methyl-d-aspartate receptors in the regulation of cerebral blood flow
- (2021) Sharon Negri et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Nonionotropic Action of Endothelial NMDA Receptors on Blood–Brain Barrier Permeability via Rho/ROCK-Mediated Phosphorylation of Myosin
- (2020) Anupriya Mehra et al. JOURNAL OF NEUROSCIENCE
- Caveolae in CNS arterioles mediate neurovascular coupling
- (2020) Brian W. Chow et al. NATURE
- STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons
- (2020) Joanna Gruszczynska-Biegala et al. Cells
- Mechanisms underlying selective coupling of endothelial Ca 2+ signals with eNOS versus IK/SK channels in systemic and pulmonary arteries
- (2020) Matteo Ottolini et al. JOURNAL OF PHYSIOLOGY-LONDON
- Nicotinic acid adenine dinucleotide phosphate activates two‐pore channel TPC1 to mediate lysosomal Ca 2+ release in endothelial colony‐forming cells
- (2020) Francesco Moccia et al. JOURNAL OF CELLULAR PHYSIOLOGY
- NMDA Receptors in Astrocytes
- (2019) Alexei Verkhratsky et al. NEUROCHEMICAL RESEARCH
- Endothelial NMDA receptors mediate activity-dependent brain hemodynamic responses in mice
- (2019) Adam D. Hogan-Cann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Histamine induces intracellular Ca 2+ oscillations and nitric oxide release in endothelial cells from brain microvascular circulation
- (2019) Roberto Berra‐Romani et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Arachidonic Acid Evokes an Increase in Intracellular Ca2+ Concentration and Nitric Oxide Production in Endothelial Cells from Human Brain Microcirculation
- (2019) Roberto Berra-Romani et al. Cells
- Group 1 metabotropic glutamate receptors trigger glutamate-induced intracellular Ca2+ signals and nitric oxide release in human brain microvascular endothelial cells
- (2019) Sharon Negri et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Deletion of calcineurin from GFAP‐expressing astrocytes impairs excitability of cerebellar and hippocampal neurons through astroglial Na + /K + ATPase
- (2019) Laura Tapella et al. GLIA
- Circulating tPA contributes to neurovascular coupling by a mechanism involving the endothelial NMDA receptors
- (2019) Antoine Anfray et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Aging Alters Cerebrovascular Endothelial GPCR and K+ Channel Function: Divergent Role of Biological Sex
- (2019) Md A Hakim et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- N-methyl-D-aspartate (NMDA) receptor expression and function is required for early chondrogenesis
- (2019) Csaba Matta et al. Cell Communication and Signaling
- The Role of Endothelial Ca2+ Signaling in Neurovascular Coupling: A View from the Lumen
- (2018) Germano Guerra et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Vascular Compartmentalization of Functional Hyperemia from the Synapse to the Pia
- (2018) Ravi L. Rungta et al. NEURON
- Comparison of a Rat Primary Cell-Based Blood-Brain Barrier Model With Epithelial and Brain Endothelial Cell Lines: Gene Expression and Drug Transport
- (2018) Szilvia Veszelka et al. Frontiers in Molecular Neuroscience
- Muscarinic M5 receptors trigger acetylcholine-induced Ca2+ signals and nitric oxide release in human brain microvascular endothelial cells
- (2018) Estella Zuccolo et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Flux-Independent NMDAR Signaling: Molecular Mediators, Cellular Functions, and Complexities
- (2018) Pavel Montes de Oca Balderas INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Glutamate triggers intracellular Ca2+ oscillations and nitric oxide release by inducing NAADP- and InsP3 -dependent Ca2+ release in mouse brain endothelial cells
- (2018) Estella Zuccolo et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Hippocampal mGluR1-dependent long-term potentiation requires NAADP-mediated acidic store Ca2+ signaling
- (2018) William J. Foster et al. Science Signaling
- Excitotoxic superoxide production and neuronal death require both ionotropic and non-ionotropic NMDA receptor signaling
- (2018) Angela M. Minnella et al. Scientific Reports
- Endolysosomal Ca2+ Signalling and Cancer Hallmarks: Two-Pore Channels on the Move, TRPML1 Lags Behind!
- (2018) Pawan Faris et al. Cancers
- Metabotropic functions of the NMDA receptor and an evolving rationale for exploring NR2A-selective positive allosteric modulators for the treatment of autism spectrum disorder
- (2018) Jessica A. Burket et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Neurovascular-neuroenergetic coupling axis in the brain: master regulation by nitric oxide and consequences in aging and neurodegeneration
- (2017) Cátia F. Lourenço et al. FREE RADICAL BIOLOGY AND MEDICINE
- Unconventional NMDA Receptor Signaling
- (2017) Kim Dore et al. JOURNAL OF NEUROSCIENCE
- Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow
- (2017) Thomas A Longden et al. NATURE NEUROSCIENCE
- Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease
- (2017) Kassandra Kisler et al. NATURE REVIEWS NEUROSCIENCE
- The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease
- (2017) Costantino Iadecola NEURON
- Differential Regulation of Evoked and Spontaneous Release by Presynaptic NMDA Receptors
- (2017) Therése Abrahamsson et al. NEURON
- Targeting Stim and Orai Proteins as an Alternative Approach in Anticancer Therapy
- (2016) Francesco Moccia et al. CURRENT MEDICINAL CHEMISTRY
- Granular Layer Neurons Control Cerebellar Neurovascular Coupling Through an NMDA Receptor/NO-Dependent System
- (2016) Lisa Mapelli et al. JOURNAL OF NEUROSCIENCE
- Spatial Ca2+ profiling: decrypting the universal cytosolic Ca2+ oscillation
- (2016) Krishna Samanta et al. JOURNAL OF PHYSIOLOGY-LONDON
- Exploring the biophysical evidence that mammalian two-pore channels are NAADP-activated calcium-permeable channels
- (2016) Samantha J. Pitt et al. JOURNAL OF PHYSIOLOGY-LONDON
- Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity
- (2016) Nicholas L Weilinger et al. NATURE NEUROSCIENCE
- Emerging roles of GluN3-containing NMDA receptors in the CNS
- (2016) Isabel Pérez-Otaño et al. NATURE REVIEWS NEUROSCIENCE
- ET-1 Stimulates Superoxide Production by eNOS Following Exposure of Vascular Endothelial Cells to Endotoxin
- (2016) Deepak Gopalakrishna et al. SHOCK
- Physiological Roles of Non-Neuronal NMDA Receptors
- (2016) Adam D. Hogan-Cann et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Glutamate induces autophagy via the two-pore channels in neural cells
- (2016) Gustavo J. S. Pereira et al. Oncotarget
- A primer of NAADP-mediated Ca2+ signalling: From sea urchin eggs to mammalian cells
- (2015) Antony Galione CELL CALCIUM
- Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5–Nrf2 pathway
- (2015) D Jimenez-Blasco et al. CELL DEATH AND DIFFERENTIATION
- Non-Ionotropic NMDA Receptor Signaling Drives Activity-Induced Dendritic Spine Shrinkage
- (2015) I. S. Stein et al. JOURNAL OF NEUROSCIENCE
- A Metabotropic-Like Flux-Independent NMDA Receptor Regulates Ca2+ Exit from Endoplasmic Reticulum and Mitochondrial Membrane Potential in Cultured Astrocytes
- (2015) Pavel Montes de Oca Balderas et al. PLoS One
- Agonist binding to the NMDA receptor drives movement of its cytoplasmic domain without ion flow
- (2015) Kim Dore et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Conformational signaling required for synaptic plasticity by the NMDA receptor complex
- (2015) Jonathan Aow et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Stim and Orai proteins in neuronal Ca2+ signaling and excitability
- (2015) Francesco Moccia et al. Frontiers in Cellular Neuroscience
- Coupling Mechanism and Significance of the BOLD Signal: A Status Report
- (2014) Elizabeth M.C. Hillman Annual Review of Neuroscience
- Neurovascular coupling in hippocampus is mediated via diffusion by neuronal-derived nitric oxide
- (2014) Cátia F. Lourenço et al. FREE RADICAL BIOLOGY AND MEDICINE
- Hydrogen Sulfide Epigenetically Attenuates Homocysteine-Induced Mitochondrial Toxicity Mediated Through NMDA Receptor in Mouse Brain Endothelial (bEnd3) Cells
- (2014) Pradip K. Kamat et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Capillary pericytes regulate cerebral blood flow in health and disease
- (2014) Catherine N. Hall et al. NATURE
- NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease
- (2013) Pierre Paoletti et al. NATURE REVIEWS NEUROSCIENCE
- Astrocyte-induced cortical vasodilation is mediated by D-serine and endothelial nitric oxide synthase
- (2013) J. L. L. Stobart et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression
- (2013) S. Nabavi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Endothelial calcium dynamics, connexin channels and blood–brain barrier function
- (2013) Marijke De Bock et al. PROGRESS IN NEUROBIOLOGY
- Ca2+-dependent nitric oxide release in the injured endothelium of excised rat aorta: a promising mechanism applying in vascular prosthetic devices in aging patients
- (2013) Roberto Berra-Romani et al. BMC Surgery
- Inflammatory activation enhances NMDA-triggered Ca2+ signalling and IL-1β secretion in primary cultures of rat astrocytes
- (2012) Franck Gérard et al. BRAIN RESEARCH
- Dynamic remodeling of scaffold interactions in dendritic spines controls synaptic excitability
- (2012) Enora Moutin et al. JOURNAL OF CELL BIOLOGY
- A single GluN2 subunit residue controls NMDA receptor channel properties via intersubunit interaction
- (2012) Beth Siegler Retchless et al. NATURE NEUROSCIENCE
- GluN3 subunit-containing NMDA receptors: not just one-trick ponies
- (2012) Svenja Pachernegg et al. TRENDS IN NEUROSCIENCES
- Molecular mechanisms of endolysosomal Ca2+signalling in health and disease
- (2011) Anthony J. Morgan et al. BIOCHEMICAL JOURNAL
- Distinct pharmacological and functional properties of NMDA receptors in mouse cortical astrocytes
- (2011) Oleg Palygin et al. BRITISH JOURNAL OF PHARMACOLOGY
- Orai1 and CRAC Channel Dependence of VEGF-Activated Ca 2+ Entry and Endothelial Tube Formation
- (2011) Jing Li et al. CIRCULATION RESEARCH
- Coactivation of NMDA Receptors by Glutamate and d-Serine Induces Dilation of Isolated Middle Cerebral Arteries
- (2011) Jillian L LeMaistre et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Pyramidal Neurons Are "Neurogenic Hubs" in the Neurovascular Coupling Response to Whisker Stimulation
- (2011) C. Lecrux et al. JOURNAL OF NEUROSCIENCE
- Addition of NMDA-receptor antagonist MK801 during oxygen/glucose deprivation moderately attenuates the upregulation of glucose uptake after subsequent reoxygenation in brain endothelial cells
- (2011) Winfried Neuhaus et al. NEUROSCIENCE LETTERS
- Purine receptors and Ca2+ signalling in the human blood–brain barrier endothelial cell line hCMEC/D3
- (2011) Willem Bintig et al. Purinergic Signalling
- Endothelial SKCa and IKCa Channels Regulate Brain Parenchymal Arteriolar Diameter and Cortical Cerebral Blood Flow
- (2010) Rachael M Hannah et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- The receptor subunits generating NMDA receptor mediated currents in oligodendrocytes
- (2010) Valeria Burzomato et al. JOURNAL OF PHYSIOLOGY-LONDON
- Glutamate Receptor Ion Channels: Structure, Regulation, and Function
- (2010) S. F. Traynelis et al. PHARMACOLOGICAL REVIEWS
- Oxidative stress upregulates the NMDA receptor on cerebrovascular endothelium
- (2009) Christian Betzen et al. FREE RADICAL BIOLOGY AND MEDICINE
- Phosphorylation-independent Regulation of Metabotropic Glutamate Receptor 5 Desensitization and Internalization by G Protein-coupled Receptor Kinase 2 in Neurons
- (2009) Fabiola M. Ribeiro et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Temperature dependence of N-methyl-d-aspartate receptor channels and N-methyl-d-aspartate receptor excitatory postsynaptic currents
- (2009) M. Korinek et al. NEUROSCIENCE
- Direct Interaction Enables Cross-talk between Ionotropic and Group I Metabotropic Glutamate Receptors
- (2008) Julie Perroy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Activation of recombinant NR1/NR2C NMDA receptors
- (2008) Shashank M. Dravid et al. JOURNAL OF PHYSIOLOGY-LONDON
- Methods for studying store-operated calcium entry
- (2008) Gary S. Bird et al. METHODS
- Shuffling the Deck Anew: How NR3 Tweaks NMDA Receptor Function
- (2008) Nora A. Cavara et al. MOLECULAR NEUROBIOLOGY
- MK801 blocks hypoxic blood–brain-barrier disruption and leukocyte adhesion
- (2008) Christoph R.W. Kuhlmann et al. NEUROSCIENCE LETTERS
- Caveolin-1 expression is essential for N-methyl-d-aspartate receptor-mediated Src and extracellular signal-regulated kinase 1/2 activation and protection of primary neurons from ischemic cell death
- (2007) Brian P. Head et al. FASEB JOURNAL
- Temperature dependence of NR1/NR2B NMDA receptor channels
- (2007) O. Cais et al. NEUROSCIENCE
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