Soluble TREM2: Innocent bystander or active player in neurological diseases?

The role of innate immune genes in Alzheimer's disease

(2021) Ana Griciuc et al.   CURRENT OPINION IN NEUROLOGY

Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia

(2021) Yifei Dong et al.   NATURE NEUROSCIENCE

CSF sTREM2 IS ELEVATED IN A SUBSET IN GRN-RELATED FRONTOTEMPORAL DEMENTIA

(2021) Emma L. van der Ende et al.   NEUROBIOLOGY OF AGING

African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants

(2021) Suzanne E. Schindler et al.   Neurology-Genetics

TREM2 expression in the brain and biological fluids in prion diseases

(2021) Daniela Diaz-Lucena et al.   ACTA NEUROPATHOLOGICA

Alternative Splicing Regulation of Low-Frequency Genetic Variants in Exon 2 of TREM2 in Alzheimer’s Disease by Splicing-Based Aggregation

(2021) Seonggyun Han et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel TREM2 splicing isoform that lacks the V‐set immunoglobulin domain is abundant in the human brain

(2021) Kostantin Kiianitsa et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Microglial activation and tau propagate jointly across Braak stages

(2021) Tharick A. Pascoal et al.   NATURE MEDICINE

Association of Aortic Stiffness With Biomarkers of Neuroinflammation, Synaptic Dysfunction, and Neurodegeneration

(2021) Elizabeth E. Moore et al.   NEUROLOGY

Associations of Sleep Characteristics with Cerebrospinal Fluid sTREM2 in Cognitively Normal Older Adults: the CABLE Study

(2021) He-Ying Hu et al.   NEUROTOXICITY RESEARCH

Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain

(2021) Aleksandra Szykowska et al.   STRUCTURE

The relationship of soluble TREM2 to other biomarkers of sporadic Alzheimer’s disease

(2021) So-Hee Park et al.   Scientific Reports

Large-scale integration of the plasma proteome with genetics and disease

(2021) Egil Ferkingstad et al.   NATURE GENETICS

CHIT1 at Diagnosis Reflects Long‐Term Multiple Sclerosis Disease Activity

(2020) Emanuela Oldoni et al.   ANNALS OF NEUROLOGY

Soluble TREM2 is elevated in Parkinson’s disease subgroups with increased CSF tau

(2020) Edward N Wilson et al.   BRAIN

Soluble TREM2 and Inflammatory Proteins in Alzheimer’s Disease Cerebrospinal Fluid

(2020) Boris-Stephan Rauchmann et al.   JOURNAL OF ALZHEIMERS DISEASE

Increased CSF Soluble TREM2 Concentration in Patients With Neurosyphilis

(2020) Wurong Li et al.   Frontiers in Neurology

Cerebrospinal Fluid YKL-40 and Chitotriosidase Levels in Frontotemporal Dementia Vary by Clinical, Genetic and Pathological Subtype

(2020) Ione O.C. Woollacott et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region

(2020) Kai Schlepckow et al.   EMBO Molecular Medicine

Transcriptomic profiling of microglia and astrocytes throughout aging

(2020) Jie Pan et al.   Journal of Neuroinflammation

Cerebrospinal fluid phospho-tau T217 outperforms T181 as a biomarker for the differential diagnosis of Alzheimer’s disease and PET amyloid-positive patient identification

(2020) Nicolas R. Barthélemy et al.   Alzheimers Research & Therapy

TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

(2020) Francesca Cignarella et al.   ACTA NEUROPATHOLOGICA

Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model

(2020) Shoutang Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TREM2 ectodomain and its soluble form in Alzheimer’s disease

(2020) Jiaolong Yang et al.   Journal of Neuroinflammation

Functional insights from biophysical study of TREM2 interactions with apoE and Aβ 1‐42

(2020) Daniel L. Kober et al.   Alzheimers & Dementia

Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition

(2020) Brittani R. Price et al.   Journal of Neuroinflammation

Cerebrospinal fluid sTREM2 in Alzheimer’s disease: comparisons between clinical presentation and AT classification

(2020) Anne-Brita Knapskog et al.   Scientific Reports

Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

(2019) Marc Suárez-Calvet et al.   Molecular Neurodegeneration

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

(2019) Li Zhong et al.   Nature Communications

TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers

(2019) Jorge L. Del-Aguila et al.   Molecular Neurodegeneration

Exercise as a potential modulator of inflammation in patients with Alzheimer's disease measured in cerebrospinal fluid and plasma

(2019) Camilla Steen Jensen et al.   EXPERIMENTAL GERONTOLOGY

Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease

(2019) Michael Ewers et al.   Science Translational Medicine

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk

(2019) Yuetiva Deming et al.   Science Translational Medicine

Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriers

(2019) Nicholas J. Ashton et al.   Alzheimers Research & Therapy

Analysis of Cerebrospinal Fluid Soluble TREM2 and Polymorphisms in Sporadic Parkinson’s Disease in a Chinese Population

(2019) Guoyou Peng et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Proteolytic ectodomain shedding of membrane proteins in mammals—hardware, concepts, and recent developments

(2018) Stefan F Lichtenthaler et al.   EMBO JOURNAL

Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism

(2018) Wilbur M. Song et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Multiple Sclerosis

(2018) Daniel S. Reich et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inflammatory markers of CHMP2B-mediated frontotemporal dementia

(2018) Peter Roos et al.   JOURNAL OF NEUROIMMUNOLOGY

Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup

(2018) Ione O. C. Woollacott et al.   Alzheimers Research & Therapy

CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline

(2018) Marc Suárez‐Calvet et al.   EMBO Molecular Medicine

CSF soluble TREM2 as a measure of immune response along the Alzheimer's disease continuum

(2018) Boris-Stephan Rauchmann et al.   NEUROBIOLOGY OF AGING

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Soluble TREM2 induces inflammatory responses and enhances microglial survival

(2017) Li Zhong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Assessment of neuroinflammation in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study

(2017) Morten Gersel Stokholm et al.   LANCET NEUROLOGY

ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157

(2017) Dominik Feuerbach et al.   NEUROSCIENCE LETTERS

Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status

(2016) Laura Piccio et al.   ACTA NEUROPATHOLOGICA

Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease

(2016) Juan Domingo Gispert et al.   Alzheimers & Dementia

sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers

(2016) Marc Suárez‐Calvet et al.   EMBO Molecular Medicine

CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

(2016) Bob Olsson et al.   LANCET NEUROLOGY

Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer’s disease

(2016) Amanda Heslegrave et al.   Molecular Neurodegeneration

Soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis treated with natalizumab or mitoxantrone

(2016) Annika Öhrfelt et al.   Multiple Sclerosis Journal

Assessment of the genetic variance of late-onset Alzheimer's disease

(2016) Perry G. Ridge et al.   NEUROBIOLOGY OF AGING

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

Early changes in CSF sTREM2 in dominantly inherited Alzheimers disease occur after amyloid deposition and neuronal injury

(2016) M. Suarez-Calvet et al.   Science Translational Medicine

Cerebrospinal fluid soluble TREM2 in aging and Alzheimer’s disease

(2016) Kristi Henjum et al.   Alzheimers Research & Therapy

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

(2016) Daniel L Kober et al.   eLife

Soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis treated with natalizumab or mitoxantrone

(2016) Annika Öhrfelt et al.   Multiple Sclerosis Journal

TREM2 regulates microglial cell activation in response to demyelination in vivo

(2015) Claudia Cantoni et al.   ACTA NEUROPATHOLOGICA

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

(2015) Yuka Atagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E

(2015) Charles C. Bailey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TREM2 sustains microglial expansion during aging and response to demyelination

(2015) Pietro Luigi Poliani et al.   JOURNAL OF CLINICAL INVESTIGATION

TREM-2 promotes macrophage survival and lung disease after respiratory viral infection

(2015) Kangyun Wu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Deficiency Attenuates Phagocytic Activities of Microglia and Exacerbates Ischemic Damage in Experimental Stroke

(2015) M. Kawabori et al.   JOURNAL OF NEUROSCIENCE

Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus

(2015) Ji-Seon Park et al.   TRAFFIC

Coding variants in TREM2 increase risk for Alzheimer's disease

(2014) Sheng Chih Jin et al.   HUMAN MOLECULAR GENETICS

Homozygous TREM2 mutation in a family with atypical frontotemporal dementia

(2014) Isabelle Le Ber et al.   NEUROBIOLOGY OF AGING

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

(2014) G. Kleinberger et al.   Science Translational Medicine

TREM2Variant p.R47H as a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis

(2014) Janet Cady et al.   JAMA Neurology

Structure, expression pattern and biological activity of molecular complex TREM-2/DAP12

(2013) Agnieszka Paradowska-Gorycka et al.   HUMAN IMMUNOLOGY

Sequential Proteolytic Processing of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Protein by Ectodomain Shedding and γ-Secretase-dependent Intramembranous Cleavage

(2013) Patrick Wunderlich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

(2013) Sruti Rayaprolu et al.   Molecular Neurodegeneration

Insights into TREM2 biology by network analysis of human brain gene expression data

(2013) Paola Forabosco et al.   NEUROBIOLOGY OF AGING

Using Exome Sequencing to Reveal Mutations in TREM2 Presenting as a Frontotemporal Dementia–like Syndrome Without Bone Involvement

(2013) Rita João Guerreiro et al.   JAMA Neurology

TREM2 and  -Catenin Regulate Bone Homeostasis by Controlling the Rate of Osteoclastogenesis

(2012) K. Otero et al.   JOURNAL OF IMMUNOLOGY

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome-wide association study of Alzheimer's disease

(2012) M I Kamboh et al.   Translational Psychiatry

TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells

(2011) Hiroaki Ito et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

Prions

(2011) D. W. Colby et al.   Cold Spring Harbor Perspectives in Biology

TREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1

(2010) Q. Peng et al.   Science Signaling

TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria

(2009) Elsa-Noah N'Diaye et al.   JOURNAL OF CELL BIOLOGY

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

(2009) Christine L. Hsieh et al.   JOURNAL OF NEUROCHEMISTRY

Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation

(2008) Laura Piccio et al.   BRAIN