TREM2 expression in the brain and biological fluids in prion diseases

Diagnostic Accuracy of Prion Disease Biomarkers in Iatrogenic Creutzfeldt-Jakob Disease

(2020) Franc Llorens et al.   Biomolecules

TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice

(2020) Shengpan Chen et al.   Journal of Neuroinflammation

A prognostic model for overall survival in sporadic Creutzfeldt‐Jakob disease

(2020) Franc Llorens et al.   Alzheimers & Dementia

The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

(2020) Aleksandra Deczkowska et al.   CELL

Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints

(2020) Eric Vallabh Minikel et al.   NUCLEIC ACIDS RESEARCH

Prions from Sporadic Creutzfeldt-Jakob Disease Patients Propagate as Strain Mixtures

(2020) Hervé Cassard et al.   mBio

Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

(2019) Marc Suárez-Calvet et al.   Molecular Neurodegeneration

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

(2019) Li Zhong et al.   Nature Communications

Prion protein quantification in human cerebrospinal fluid as a tool for prion disease drug development

(2019) Sonia M. Vallabh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of Blood and Cerebrospinal Fluid Tau Level and Other Biomarkers With Survival Time in Sporadic Creutzfeldt-Jakob Disease

(2019) Adam M. Staffaroni et al.   JAMA Neurology

Plasma YKL-40 in the spectrum of neurodegenerative dementia

(2019) Anna Villar-Piqué et al.   Journal of Neuroinflammation

CSF biomarkers of neuroinflammation in distinct forms and subtypes of neurodegenerative dementia

(2019) Samir Abu-Rumeileh et al.   Alzheimers Research & Therapy

Cerebrospinal fluid neurofilament light levels in neurodegenerative dementia: Evaluation of diagnostic accuracy in the differential diagnosis of prion diseases

(2018) Inga Zerr et al.   Alzheimers & Dementia

Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism

(2018) Wilbur M. Song et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Soluble TREM2 and biomarkers of central and peripheral inflammation in neurodegenerative disease

(2018) L.M. Bekris et al.   JOURNAL OF NEUROIMMUNOLOGY

Multiple sclerosis

(2018) Alan J Thompson et al.   LANCET

The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer’s disease

(2018) Paul J. Cheng-Hathaway et al.   Molecular Neurodegeneration

Validation and utilization of amended diagnostic criteria in Creutzfeldt-Jakob disease surveillance

(2018) Peter Hermann et al.   NEUROLOGY

Review: Fluid biomarkers in the human prion diseases

(2018) Andrew G.B. Thompson et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

CSF soluble TREM2 as a measure of immune response along the Alzheimer's disease continuum

(2018) Boris-Stephan Rauchmann et al.   NEUROBIOLOGY OF AGING

Plasma and cerebrospinal fluid tau and neurofilament concentrations in rapidly progressive neurological syndromes: a neuropathology-based cohort

(2017) G. G. Kovacs et al.   EUROPEAN JOURNAL OF NEUROLOGY

Validation of α-Synuclein as a CSF Biomarker for Sporadic Creutzfeldt-Jakob Disease

(2017) Franc Llorens et al.   MOLECULAR NEUROBIOLOGY

YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias

(2017) Franc Llorens et al.   Molecular Neurodegeneration

Glial Fibrillary Acidic Protein and Protein S-100B: Different Concentration Pattern of Glial Proteins in Cerebrospinal Fluid of Patients with Alzheimer's Disease and Creutzfeldt-Jakob Disease

(2017) Sarah Jesse et al.   JOURNAL OF ALZHEIMERS DISEASE

Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status

(2016) Laura Piccio et al.   ACTA NEUROPATHOLOGICA

Comparative analysis of cerebrospinal fluid biomarkers in the differential diagnosis of neurodegenerative dementia

(2016) Franc Llorens et al.   Alzheimers & Dementia

sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers

(2016) Marc Suárez‐Calvet et al.   EMBO Molecular Medicine

Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer’s disease brains

(2016) Li Ma et al.   Molecular Neurodegeneration

Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer’s disease

(2016) Amanda Heslegrave et al.   Molecular Neurodegeneration

Soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis treated with natalizumab or mitoxantrone

(2016) Annika Öhrfelt et al.   Multiple Sclerosis Journal

Cerebrospinal fluid soluble TREM2 in aging and Alzheimer’s disease

(2016) Kristi Henjum et al.   Alzheimers Research & Therapy

Soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis treated with natalizumab or mitoxantrone

(2016) Annika Öhrfelt et al.   Multiple Sclerosis Journal

Neurofilaments in blood and CSF for diagnosis and prediction of onset in Creutzfeldt-Jakob disease

(2016) Petra Steinacker et al.   Scientific Reports

TREM-2 promotes macrophage survival and lung disease after respiratory viral infection

(2015) Kangyun Wu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stability and Reproducibility Underscore Utility of RT-QuIC for Diagnosis of Creutzfeldt-Jakob Disease

(2015) Maria Cramm et al.   MOLECULAR NEUROBIOLOGY

Validation of 14-3-3 Protein as a Marker in Sporadic Creutzfeldt-Jakob Disease Diagnostic

(2015) Matthias Schmitz et al.   MOLECULAR NEUROBIOLOGY

Cerebrospinal fluid tau levels are a marker for molecular subtype in sporadic Creutzfeldt-Jakob disease

(2015) André Karch et al.   NEUROBIOLOGY OF AGING

Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains

(2015) Caihong Zhu et al.   NEUROBIOLOGY OF AGING

Subtype and regional regulation of prion biomarkers in sporadic Creutzfeldt-Jakob disease

(2015) Franc Llorens et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia

(2014) Catherine F. Slattery et al.   Alzheimers & Dementia

TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices

(2014) Lih-Fen Lue et al.   BRAIN PATHOLOGY

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

(2014) G. Kleinberger et al.   Science Translational Medicine

Evidence for zoonotic potential of ovine scrapie prions

(2014) Hervé Cassard et al.   Nature Communications

Subtype and Regional-Specific Neuroinflammation in Sporadic Creutzfeldt–Jakob Disease

(2014) Franc Llorens et al.   Frontiers in Aging Neuroscience

TREM2Variant p.R47H as a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis

(2014) Janet Cady et al.   JAMA Neurology

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

(2013) Sruti Rayaprolu et al.   Molecular Neurodegeneration

A novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family

(2013) Rita Guerreiro et al.   NEUROBIOLOGY OF AGING

Consensus classification of human prion disease histotypes allows reliable identification of molecular subtypes: an inter-rater study among surveillance centres in Europe and USA

(2012) Piero Parchi et al.   ACTA NEUROPATHOLOGICA

Real time quaking-induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease

(2012) Lynne I. McGuire et al.   ANNALS OF NEUROLOGY

Sporadic human prion diseases: molecular insights and diagnosis

(2012) Gianfranco Puoti et al.   LANCET NEUROLOGY

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

A harmonized classification system for FTLD-TDP pathology

(2011) Ian R. A. Mackenzie et al.   ACTA NEUROPATHOLOGICA

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

pROC: an open-source package for R and S+ to analyze and compare ROC curves

(2011) Xavier Robin et al.   BMC BIOINFORMATICS

Genetic Creutzfeldt–Jakob disease and fatal familial insomnia: insights into phenotypic variability and disease pathogenesis

(2010) Sabina Capellari et al.   ACTA NEUROPATHOLOGICA

Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease

(2009) I. Zerr et al.   BRAIN

Cerebrospinal fluid biomarkers in human genetic transmissible spongiform encephalopathies

(2009) Anna Ladogana et al.   JOURNAL OF NEUROLOGY

Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation

(2008) Laura Piccio et al.   BRAIN

14-3-3 CSF levels in sporadic Creutzfeldt–Jakob disease differ across molecular subtypes

(2008) K. Gmitterová et al.   NEUROBIOLOGY OF AGING