Synergistic activation of the insulin receptor via two distinct sites

Understanding insulin and its receptor from their three-dimensional structure

(2021) Michael C. Lawrence   Molecular Metabolism

Structural basis of the activation of c-MET receptor

(2021) Emiko Uchikawa et al.   Nature Communications

Insulin and epidermal growth factor receptor family members share parallel activation mechanisms

(2020) Kathryn M. Ferguson et al.   PROTEIN SCIENCE

Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling

(2019) Eunhee Choi et al.   Nature Communications

Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor–ligand complex

(2019) Emiko Uchikawa et al.   eLife

Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands

(2019) Jie Li et al.   eLife

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain

(2019) Theresia Gutmann et al.   JOURNAL OF CELL BIOLOGY

Structural basis of the activation of type 1 insulin-like growth factor receptor

(2019) Jie Li et al.   Nature Communications

Visualization of ligand-induced transmembrane signaling in the full-length human insulin receptor

(2018) Theresia Gutmann et al.   JOURNAL OF CELL BIOLOGY

How ligand binds to the type 1 insulin-like growth factor receptor

(2018) Yibin Xu et al.   Nature Communications

Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis

(2018) Giovanna Scapin et al.   NATURE

Mechanisms of Insulin Action and Insulin Resistance

(2018) Max C. Petersen et al.   PHYSIOLOGICAL REVIEWS

The signalling conformation of the insulin receptor ectodomain

(2018) Felix Weis et al.   Nature Communications

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Biochemical and cellular properties of insulin receptor signalling

(2017) Rebecca A. Haeusler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitotic Checkpoint Regulators Control Insulin Signaling and Metabolic Homeostasis

(2016) Eunhee Choi et al.   CELL

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Integration and global analysis of isothermal titration calorimetry data for studying macromolecular interactions

(2016) Chad A Brautigam et al.   Nature Protocols

Insulin/receptor binding: The last piece of the puzzle?

(2015) Pierre De Meyts   BIOESSAYS

Sampling the conformational space of the catalytic subunit of human γ-secretase

(2015) Xiao-chen Bai et al.   eLife

Insulin Receptor Signaling in Normal and Insulin-Resistant States

(2014) J. Boucher et al.   Cold Spring Harbor Perspectives in Biology

How IGF-1 activates its receptor

(2014) Jennifer M Kavran et al.   eLife

Chemical Synthesis of Insulin Analogs through a Novel Precursor

(2013) Alexander N. Zaykov et al.   ACS Chemical Biology

High-Precision Isothermal Titration Calorimetry with Automated Peak-Shape Analysis

(2012) Sandro Keller et al.   ANALYTICAL CHEMISTRY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Total Synthesis of desB30 Insulin Analogues by Biomimetic Folding of Single-Chain Precursors

(2008) A. Pernille Tofteng et al.   CHEMBIOCHEM