Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands

Structure of the IFNγ receptor complex guides design of biased agonists

(2019) Juan L. Mendoza et al.   NATURE

Physical Principles of Membrane Shape Regulation by the Glycocalyx

(2019) Carolyn R. Shurer et al.   CELL

Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain

(2019) Janna M. Bigalke et al.   Science Advances

GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance

(2019) Harding H. Luan et al.   CELL

Entropic Control of Receptor Recycling Using Engineered Ligands

(2018) Andre C.M. DeGroot et al.   BIOPHYSICAL JOURNAL

Structure and biophysical characterization of the human full-length neurturin–GFRa2 complex: A role for heparan sulfate in signaling

(2018) Jenny Sandmark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum

(2018) Marlena S. Fejzo et al.   Nature Communications

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

(2017) Jer-Yuan Hsu et al.   NATURE

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

(2017) Linda Yang et al.   NATURE MEDICINE

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

(2017) Shannon E Mullican et al.   NATURE MEDICINE

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

(2017) Paul J Emmerson et al.   NATURE MEDICINE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex

(2017) Guijun Shang et al.   eLife

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution

(2016) Thi Hoang Duong Nguyen et al.   NATURE

Manipulation of Subunit Stoichiometry in Heteromeric Membrane Proteins

(2016) Claudio L. Morales-Perez et al.   STRUCTURE

A Structural Perspective on the Regulation of the Epidermal Growth Factor Receptor

(2015) Erika Kovacs et al.   Annual Review of Biochemistry

Atomic structure of the apoptosome: mechanism of cytochromec- and dATP-mediated activation of Apaf-1

(2015) Mengying Zhou et al.   GENES & DEVELOPMENT

Distinct Temporal Regulation of RET Isoform Internalization: Roles of Clathrin and AP2

(2015) Mathieu J. F. Crupi et al.   TRAFFIC

Sampling the conformational space of the catalytic subunit of human γ-secretase

(2015) Xiao-chen Bai et al.   eLife

RET Recognition of GDNF-GFRα1 Ligand by a Composite Binding Site Promotes Membrane-Proximal Self-Association

(2014) Kerry M. Goodman et al.   Cell Reports

How IGF-1 activates its receptor

(2014) Jennifer M Kavran et al.   eLife

Recorded scan times can limit the accuracy of sedimentation coefficients in analytical ultracentrifugation

(2013) Huaying Zhao et al.   ANALYTICAL BIOCHEMISTRY

Structure and Physiology of the RET Receptor Tyrosine Kinase

(2013) C. F. Ibanez   Cold Spring Harbor Perspectives in Biology

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Alternative splicing results in RET isoforms with distinct trafficking properties

(2012) Douglas S. Richardson et al.   MOLECULAR BIOLOGY OF THE CELL

Prevention of overfitting in cryo-EM structure determination

(2012) Sjors H W Scheres et al.   NATURE METHODS

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

A Bayesian View on Cryo-EM Structure Determination

(2011) Sjors H.W. Scheres   JOURNAL OF MOLECULAR BIOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations

(2010) Svend Kjær et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Comparison of GFL–GFRα complexes: further evidence relating GFL bend angle to RET signalling

(2009) Vimal Parkash et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications