How IGF-1 activates its receptor

The FRET Signatures of Noninteracting Proteins in Membranes: Simulations and Experiments

(2014) Christopher King et al.   BIOPHYSICAL JOURNAL

Insulin Receptor Activation with Transmembrane Domain Ligands

(2014) Jongsoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The insulin receptor changes conformation in unforeseen ways on ligand binding: Sharpening the picture of insulin receptor activation

(2013) Colin W. Ward et al.   BIOESSAYS

Architecture and Membrane Interactions of the EGF Receptor

(2013) Anton Arkhipov et al.   CELL

Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor

(2013) Nicholas F. Endres et al.   CELL

Structural biology: Insulin meets its receptor

(2013) Stevan R. Hubbard   NATURE

How insulin engages its primary binding site on the insulin receptor

(2013) John G. Menting et al.   NATURE

Production of Plasma Membrane Vesicles with Chloride Salts and Their Utility as a Cell Membrane Mimetic for Biophysical Characterization of Membrane Protein Interactions

(2012) Nuala Del Piccolo et al.   ANALYTICAL CHEMISTRY

Similar but different: ligand-induced activation of the insulin and epidermal growth factor receptor families

(2012) Colin W Ward et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A single ligand is sufficient to activate EGFR dimers

(2012) P. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Basis of Signaling Specificity of Insulin and IGF Receptors: Neglected Corners and Recent Advances

(2012) Kenneth Siddle   Frontiers in Endocrinology

How Robust Are Protein Folding Simulations with Respect to Force Field Parameterization?

(2011) Stefano Piana et al.   BIOPHYSICAL JOURNAL

Signalling by insulin and IGF receptors: supporting acts and new players

(2011) Kenneth Siddle   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Rapid Phospho-Turnover by Receptor Tyrosine Kinases Impacts Downstream Signaling and Drug Binding

(2011) Laura B. Kleiman et al.   MOLECULAR CELL

Fine Details of IGF-1R Activation, Inhibition, and Asymmetry Determined by Associated Hydrogen /Deuterium-Exchange and Peptide Mass Mapping

(2011) Damian Houde et al.   STRUCTURE

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Measuring the Energetics of Membrane Protein Dimerization in Mammalian Membranes

(2010) Lirong Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists

(2010) B. J. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Extracellular Domain of Fibroblast Growth Factor Receptor 3 Inhibits Ligand-Independent Dimerization

(2010) L. Chen et al.   Science Signaling

In Vitro Enzymatic Characterization of Near Full Length EGFR in Activated and Inhibited States

(2009) Chen Qiu et al.   BIOCHEMISTRY

Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase

(2009) Samarjit Patnaik et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment

(2009) Natalia Jura et al.   CELL

Determination of supramolecular structure and spatial distribution of protein complexes in living cells

(2009) Valerica Raicu et al.   Nature Photonics

The Precise Sequence of FGF Receptor Autophosphorylation Is Kinetically Driven and Is Disrupted by Oncogenic Mutations

(2009) E. D. Lew et al.   Science Signaling

Quantitative Measurements of Protein Interactions in a Crowded Cellular Environment

(2008) Edwin Li et al.   ANALYTICAL CHEMISTRY

High-Affinity Insulin Binding: Insulin Interacts with Two Receptor Ligand Binding Sites†

(2008) Linda Whittaker et al.   BIOCHEMISTRY

Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment

(2008) Scott C. Mayer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment

(2008) Lori M. Miller et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

(2008) Jinhua Wu et al.   EMBO JOURNAL

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY