Transforming clinical trials in rheumatology: towards patient-centric precision medicine

Testing different thresholds for patient global assessment in defining remission for rheumatoid arthritis: are the current ACR/EULAR Boolean criteria optimal?

(2020) Paul Studenic et al.   ANNALS OF THE RHEUMATIC DISEASES

Validity of a two-component imaging-derived disease activity score for improved assessment of synovitis in early rheumatoid arthritis

(2019) Elizabeth M A Hensor et al.   RHEUMATOLOGY

Adaptive Trial Designs in Rheumatology: Report from the OMERACT Special Interest Group

(2019) Tim Pickles et al.   JOURNAL OF RHEUMATOLOGY

Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients

(2019) Frances Humby et al.   ANNALS OF THE RHEUMATIC DISEASES

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

(2019) Fan Zhang et al.   NATURE IMMUNOLOGY

Towards Defining Primary and Secondary Non-Response in Rheumatoid Arthritis Patients Treated with Anti-TNFs: Results from the BioTRAC and OBRI Registries

(2019) Edward Keystone et al.   JOURNAL OF RHEUMATOLOGY

Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes

(2019) Myles J. Lewis et al.   Cell Reports

Synovial tissue signatures enhance clinical classification and prognostic/treatment response algorithms in early inflammatory arthritis and predict requirement for subsequent biological therapy: results from the pathobiology of early arthritis cohort (PEAC)

(2019) Gloria Lliso-Ribera et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy of acetaminophen with and without oxycodone for analgesia in non-operative treatment of extremity fractures in adults: protocol for a double-blind randomized clinical trial

(2019) Tao Gao et al.   Trials

Precision medicine using different biological DMARDs based on characteristic phenotypes of peripheral T helper cells in psoriatic arthritis

(2018) Ippei Miyagawa et al.   RHEUMATOLOGY

Transcriptional Profiling of Synovial Macrophages Using Minimally Invasive Ultrasound-Guided Synovial Biopsies in Rheumatoid Arthritis

(2018) Arthur M. Mandelin et al.   Arthritis & Rheumatology

Rheumatoid arthritis

(2018) Josef S. Smolen et al.   Nature Reviews Disease Primers

Risankizumab, an IL-23 inhibitor, for ankylosing spondylitis: results of a randomised, double-blind, placebo-controlled, proof-of-concept, dose-finding phase 2 study

(2018) Dominique Baeten et al.   ANNALS OF THE RHEUMATIC DISEASES

Three Multicenter, Randomized, Double-Blind, Placebo-Controlled Studies Evaluating the Efficacy and Safety of Ustekinumab in Axial Spondyloarthritis

(2018) Atul Deodhar et al.   Arthritis & Rheumatology

Effects of B-cell directed therapy on the preclinical stage of rheumatoid arthritis: the PRAIRI study

(2018) Danielle M Gerlag et al.   ANNALS OF THE RHEUMATIC DISEASES

IL-6 inhibitor for the treatment of rheumatoid arthritis: A comprehensive review

(2018) Atsushi Ogata et al.   Modern Rheumatology

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

Secukinumab in Active Rheumatoid Arthritis: A Phase III Randomized, Double-Blind, Active Comparator- and Placebo-Controlled Study

(2017) Francisco J. Blanco et al.   Arthritis & Rheumatology

Discordance between tender and swollen joint count as well as patient's and evaluator's global assessment may reduce likelihood of remission in patients with rheumatoid arthritis and psoriatic arthritis: data from the prospective multicentre NOR-DMARD study

(2016) Brigitte Michelsen et al.   ANNALS OF THE RHEUMATIC DISEASES

Evidence of response to IL-6 inhibition in some cases of refractory spondyloarthritis-associated peripheral synovitis: Table 1

(2016) Mira Merashli et al.   ANNALS OF THE RHEUMATIC DISEASES

Tumour necrosis factor inhibition versus rituximab for patients with rheumatoid arthritis who require biological treatment (ORBIT): an open-label, randomised controlled, non-inferiority, trial

(2016) Duncan Porter et al.   LANCET

Head-to-head comparison of certolizumab pegol versus adalimumab in rheumatoid arthritis: 2-year efficacy and safety results from the randomised EXXELERATE study

(2016) Josef S Smolen et al.   LANCET

Rheumatoid arthritis

(2016) Josef S Smolen et al.   LANCET

Stratified medicine in rheumatoid arthritis—the MATURA programme

(2016) Anne Barton et al.   RHEUMATOLOGY

Review of head-to-head study designs in rheumatoid arthritis

(2016) Fleischmann R. et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Generalizability of Patients With Rheumatoid Arthritis in Biologic Agent Clinical Trials

(2016) Priyanka Vashisht et al.   ARTHRITIS CARE & RESEARCH

The Efficacy and Safety of Clazakizumab, an Anti-Interleukin-6 Monoclonal Antibody, in a Phase IIb Study of Adults With Active Psoriatic Arthritis

(2016) Philip J. Mease et al.   Arthritis & Rheumatology

Biomarker-Guided Adaptive Trial Designs in Phase II and Phase III: A Methodological Review

(2016) Miranta Antoniou et al.   PLoS One

Determinants of adherence to disease modifying anti-rheumatic drugs in White British and South Asian patients with rheumatoid arthritis: a cross sectional study

(2015) Kanta Kumar et al.   BMC MUSCULOSKELETAL DISORDERS

Patient-centric trials for therapeutic development in precision oncology

(2015) Andrew V. Biankin et al.   NATURE

Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges

(2015) Josef S. Smolen et al.   Nature Reviews Rheumatology

Personalized biological treatment for rheumatoid arthritis: a systematic review with a focus on clinical applicability

(2015) Bart V. J. Cuppen et al.   RHEUMATOLOGY

Ectopic lymphoid neogenesis is strongly associated with activation of the IL-23 pathway in rheumatoid synovitis

(2015) Juan D. Cañete et al.   ARTHRITIS RESEARCH & THERAPY

Use of Ultrasound-Guided Small Joint Biopsy to Evaluate the Histopathologic Response to Rheumatoid Arthritis Therapy: Recommendations for Application to Clinical Trials

(2015) Frances Humby et al.   Arthritis & Rheumatology

Ustekinumab for the treatment of patients with active ankylosing spondylitis: results of a 28-week, prospective, open-label, proof-of-concept study (TOPAS)

(2014) Denis Poddubnyy et al.   ANNALS OF THE RHEUMATIC DISEASES

Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics

(2014) Glynn Dennis et al.   ARTHRITIS RESEARCH & THERAPY

Assessment of short-term symptomatic efficacy of tocilizumab in ankylosing spondylitis: results of randomised, placebo-controlled trials

(2013) Joachim Sieper et al.   ANNALS OF THE RHEUMATIC DISEASES

Ultrasound-guided synovial biopsy: a safe, well-tolerated and reliable technique for obtaining high-quality synovial tissue from both large and small joints in early arthritis patients

(2013) S Kelly et al.   ANNALS OF THE RHEUMATIC DISEASES

Discontinuation of adalimumab after achieving remission in patients with established rheumatoid arthritis: 1-year outcome of the HONOR study

(2013) Yoshiya Tanaka et al.   ANNALS OF THE RHEUMATIC DISEASES

New learnings on the pathophysiology of RA from synovial biopsies

(2013) Costantino Pitzalis et al.   CURRENT OPINION IN RHEUMATOLOGY

Creative trial design in RA: optimizing patient outcomes

(2013) Maya H. Buch et al.   Nature Reviews Rheumatology

The problem of choice: current biologic agents and future prospects in RA

(2013) Ernest H. Choy et al.   Nature Reviews Rheumatology

Global Molecular Effects of Tocilizumab Therapy in Rheumatoid Arthritis Synovium

(2013) Julie Ducreux et al.   Arthritis & Rheumatology

Effect of baseline rheumatoid factor and anticitrullinated peptide antibody serotype on rituximab clinical response: a meta-analysis

(2012) John D Isaacs et al.   ANNALS OF THE RHEUMATIC DISEASES

Incomplete response of inflammatory arthritis to TNFα blockade is associated with the Th17 pathway

(2012) Saba Alzabin et al.   ANNALS OF THE RHEUMATIC DISEASES

Pretreatment synovial transcriptional profile is associated with early and late clinical response in rheumatoid arthritis patients treated with rituximab

(2012) Vanessa E Hogan et al.   ANNALS OF THE RHEUMATIC DISEASES

Head-to-head comparison of subcutaneous abatacept versus adalimumab for rheumatoid arthritis: Findings of a phase IIIb, multinational, prospective, randomized study

(2012) Michael E. Weinblatt et al.   ARTHRITIS AND RHEUMATISM

Rituximab treatment induces the expression of genes involved in healing processes in the rheumatoid arthritis synovium

(2011) I. Gutierrez-Roelens et al.   ARTHRITIS AND RHEUMATISM

A personalized medicine approach to biologic treatment of rheumatoid arthritis: a preliminary treatment algorithm

(2011) P. P. Tak   RHEUMATOLOGY

Mr Outside and Mr Inside: classic and alternative views on the pathogenesis of rheumatoid arthritis

(2010) G. Schett et al.   ANNALS OF THE RHEUMATIC DISEASES

Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis

(2009) Valérie Badot et al.   ARTHRITIS RESEARCH & THERAPY

The value of synovial cytokine expression in predicting the clinical response to TNF antagonist therapy (infliximab)

(2008) M. H. Buch et al.   RHEUMATOLOGY