Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial

Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial

(2021) Frances Humby et al.   LANCET

Fibroblast pathology in inflammatory joint disease

(2021) Lucy‐Jayne Marsh et al.   IMMUNOLOGICAL REVIEWS

Emerging roles for IL-6 family cytokines as positive and negative regulators of ectopic lymphoid structures

(2021) David G. Hill et al.   CYTOKINE

EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update

(2020) Josef S Smolen et al.   ANNALS OF THE RHEUMATIC DISEASES

B cells and tertiary lymphoid structures promote immunotherapy response

(2020) Beth A. Helmink et al.   NATURE

M3C: Monte Carlo reference-based consensus clustering

(2020) Christopher R. John et al.   Scientific Reports

Notch signalling drives synovial fibroblast identity and arthritis pathology

(2020) Kevin Wei et al.   NATURE

Translating IL-6 biology into effective treatments

(2020) Ernest H. Choy et al.   Nature Reviews Rheumatology

PAD enzymes in rheumatoid arthritis: pathogenic effectors and autoimmune targets

(2020) Ashley M. Curran et al.   Nature Reviews Rheumatology

A Pauci-Immune Synovial Pathotype Predicts Inadequate Response to TNFα-Blockade in Rheumatoid Arthritis Patients

(2020) Alessandra Nerviani et al.   Frontiers in Immunology

An approach for normalization and quality control for NanoString RNA expression data

(2020) Arjun Bhattacharya et al.   BRIEFINGS IN BIOINFORMATICS

Transforming clinical trials in rheumatology: towards patient-centric precision medicine

(2020) Costantino Pitzalis et al.   Nature Reviews Rheumatology

Predicting treatment response to IL6R blockers in rheumatoid arthritis

(2020) Bako Nouri et al.   RHEUMATOLOGY

The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts’ Consensus

(2020) Roberto Giacomelli et al.   AUTOIMMUNITY REVIEWS

Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts

(2019) Nicola Ferrari et al.   Nature Communications

Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients

(2019) Frances Humby et al.   ANNALS OF THE RHEUMATIC DISEASES

Distinct fibroblast subsets drive inflammation and damage in arthritis

(2019) Adam P. Croft et al.   NATURE

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

(2019) Fan Zhang et al.   NATURE IMMUNOLOGY

Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes

(2019) Myles J. Lewis et al.   Cell Reports

Synovial tissue signatures enhance clinical classification and prognostic/treatment response algorithms in early inflammatory arthritis and predict requirement for subsequent biological therapy: results from the pathobiology of early arthritis cohort (PEAC)

(2019) Gloria Lliso-Ribera et al.   ANNALS OF THE RHEUMATIC DISEASES

B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure

(2019) F. Rivellese et al.   Arthritis & Rheumatology

Defining refractory rheumatoid arthritis

(2018) Maya H Buch   ANNALS OF THE RHEUMATIC DISEASES

Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis

(2018) Fumitaka Mizoguchi et al.   Nature Communications

Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation

(2018) William Stephenson et al.   Nature Communications

Rheumatoid arthritis

(2018) Josef S. Smolen et al.   Nature Reviews Disease Primers

Effect of rituximab treatment on T and B cell subsets in lymph node biopsies of patients with rheumatoid arthritis

(2018) Tamara H Ramwadhdoebe et al.   RHEUMATOLOGY

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

Sample size requirements for learning to classify with high-dimensional biomarker panels

(2017) Paul McKeigue   STATISTICAL METHODS IN MEDICAL RESEARCH

Effectiveness of Targeted Therapy in Patients With Previously Untreated Metastatic Breast Cancer: A Systematic Review and Meta-Analysis

(2015) Paweł Kawalec et al.   Clinical Breast Cancer

Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer

(2015) Hossein Borghaei et al.   NEW ENGLAND JOURNAL OF MEDICINE

High expression levels of the B cell chemoattractant CXCL13 in rheumatoid synovium are a marker of severe disease

(2014) Serena Bugatti et al.   RHEUMATOLOGY

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

(2014) Charity W Law et al.   GENOME BIOLOGY

Ultrasound-guided synovial biopsy: a safe, well-tolerated and reliable technique for obtaining high-quality synovial tissue from both large and small joints in early arthritis patients

(2013) S Kelly et al.   ANNALS OF THE RHEUMATIC DISEASES

Molecular signatures of antibody responses derived from a systems biology study of five human vaccines

(2013) Shuzhao Li et al.   NATURE IMMUNOLOGY

Effect of baseline rheumatoid factor and anticitrullinated peptide antibody serotype on rituximab clinical response: a meta-analysis

(2012) John D Isaacs et al.   ANNALS OF THE RHEUMATIC DISEASES

Pretreatment synovial transcriptional profile is associated with early and late clinical response in rheumatoid arthritis patients treated with rituximab

(2012) Vanessa E Hogan et al.   ANNALS OF THE RHEUMATIC DISEASES

Interferon type I signature may predict non response upon rituximab in rheumatoid arthritis patients

(2012) Hennie G Raterman et al.   ARTHRITIS RESEARCH & THERAPY

Cutting Edge: Expression of XCR1 Defines Mouse Lymphoid-Tissue Resident and Migratory Dendritic Cells of the CD8 + Type

(2011) K. Crozat et al.   JOURNAL OF IMMUNOLOGY

Relationship between the type I interferon signature and the response to rituximab in rheumatoid arthritis patients

(2010) Rogier M. Thurlings et al.   ARTHRITIS AND RHEUMATISM

Prolectin, a Glycan-binding Receptor on Dividing B Cells in Germinal Centers

(2009) Sarah A. Graham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synovial Tissue Sublining CD68 Expression Is a Biomarker of Therapeutic Response in Rheumatoid Arthritis Clinical Trials: Consistency Across Centers

(2009) B. BRESNIHAN et al.   JOURNAL OF RHEUMATOLOGY

The abundant synovial expression of the RANK/RANKL/Osteoprotegerin system in peripheral spondylarthritis is partially disconnected from inflammation

(2008) Bernard Vandooren et al.   ARTHRITIS AND RHEUMATISM