Insulin: The master regulator of glucose metabolism

A Journey in Diabetes: From Clinical Physiology to Novel Therapeutics: The 2020 Banting Medal for Scientific Achievement Lecture

(2021) Ele Ferrannini   DIABETES

Insulin-Stimulated Muscle Glucose Uptake and Insulin Signaling in Lean and Obese Humans

(2021) Paola A Ramos et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Insulin signaling in health and disease

(2021) Alan R. Saltiel   JOURNAL OF CLINICAL INVESTIGATION

The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia

(2021) Lykke Sylow et al.   Cell Metabolism

Human white adipose tissue displays selective insulin resistance in the obese state

(2021) Enrichetta Mileti et al.   DIABETES

Defining the underlying defect in insulin action in type 2 diabetes

(2021) Thiago M. Batista et al.   DIABETOLOGIA

Fat-Secreted Ceramides Regulate Vascular Redox State and Influence Outcomes in Patients With Cardiovascular Disease

(2021) Nadia Akawi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Obesity is Associated with Increased Basal and Postprandial β-Cell Insulin Secretion Even in the Absence of Insulin Resistance

(2020) Stephan van Vliet et al.   DIABETES

Adaptation of Insulin Clearance to Metabolic Demand is a Key Determinant of Glucose Tolerance

(2020) Amalia Gastaldelli et al.   DIABETES

Hormone-sensitive lipase: sixty years later

(2020) Emeline Recazens et al.   PROGRESS IN LIPID RESEARCH

The Role of Ceramides in Insulin Resistance

(2019) Emilia Sokolowska et al.   Frontiers in Endocrinology

The role of adipose triglyceride lipase in lipid and glucose homeostasis: lessons from transgenic mice

(2019) Michael J. Trites et al.   Lipids in Health and Disease

The role of skeletal muscle Akt in the regulation of muscle mass and glucose homeostasis

(2019) N. Jaiswal et al.   Molecular Metabolism

Postnatal knockout of beta cell insulin receptor impaired insulin secretion in male mice exposed to high-fat diet stress

(2019) Amanda Oakie et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Diabetic Cardiomyopathy

(2018) Guanghong Jia et al.   CIRCULATION RESEARCH

Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars

(2018) Panu K. Luukkonen et al.   DIABETES CARE

Palmitic and Oleic Acid: The Yin and Yang of Fatty Acids in Type 2 Diabetes Mellitus

(2018) Xavier Palomer et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mechanisms of Insulin Action and Insulin Resistance

(2018) Max C. Petersen et al.   PHYSIOLOGICAL REVIEWS

How to Measure Adipose Tissue Insulin Sensitivity

(2017) Esben Søndergaard et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis

(2017) Clair Crewe et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein ingestion acutely inhibits insulin-stimulated muscle carnitine uptake in healthy young men

(2016) Chris E Shannon et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Muscle microvasculature's structural and functional specializations facilitate muscle metabolism

(2016) Yvo H. A. M. Kusters et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Pharmacological Inhibition of PI3K Reduces Adiposity and Metabolic Syndrome in Obese Mice and Rhesus Monkeys

(2015) Ana Ortega-Molina et al.   Cell Metabolism

Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance

(2014) Sarah M. Turpin et al.   Cell Metabolism

Human Muscle Fiber Type–Specific Insulin Signaling: Impact of Obesity and Type 2 Diabetes

(2014) Peter H. Albers et al.   DIABETES

Hepatic glucose sensing and integrative pathways in the liver

(2013) Maaike H. Oosterveer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Visceral Fat Accumulation During Lipid Overfeeding Is Related to Subcutaneous Adipose Tissue Characteristics in Healthy Men

(2013) Maud Alligier et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Insulin Inhibits Lipolysis in Adipocytes via the Evolutionarily Conserved mTORC1-Egr1-ATGL-Mediated Pathway

(2013) P. Chakrabarti et al.   MOLECULAR AND CELLULAR BIOLOGY

Early Microvascular Recruitment Modulates Subsequent Insulin-Mediated Skeletal Muscle Glucose Metabolism During Lipid Infusion

(2012) E. M. Eggleston et al.   DIABETES CARE

Insulin Resistance and Risk of Incident Cardiovascular Events in Adults without Diabetes: Meta-Analysis

(2012) Karin B. Gast et al.   PLoS One

Allosteric Regulation of Glycogen Synthase Controls Glycogen Synthesis in Muscle

(2010) Michale Bouskila et al.   Cell Metabolism

A Soluble Guanylate Cyclase-Dependent Mechanism Is Involved in the Regulation of Net Hepatic Glucose Uptake by Nitric Oxide in Vivo

(2010) Z. An et al.   DIABETES

Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009

(2010) R. A. DeFronzo   DIABETOLOGIA

Glucose transporters in the 21st Century

(2009) Bernard Thorens et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Muscle Contraction, but Not Insulin, Increases Microvascular Blood Volume in the Presence of Free Fatty Acid-Induced Insulin Resistance

(2009) A. C. Inyard et al.   DIABETES

Thematic Minireview Series: A Perspective on the Biology of Phosphoenolpyruvate Carboxykinase 55 Years After Its Discovery

(2009) Richard W. Hanson   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin Enhances Post-translational Processing of Nascent SREBP-1c by Promoting Its Phosphorylation and Association with COPII Vesicles

(2009) Chandrahasa R. Yellaturu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Infusing Lipid Raises Plasma Free Fatty Acids and Induces Insulin Resistance in Muscle Microvasculature

(2009) Zhenqi Liu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes

(2009) V. T. Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis

(2008) Sudha B. Biddinger et al.   Cell Metabolism

Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake

(2008) Leanne Hodson et al.   PROGRESS IN LIPID RESEARCH