- Home
- Publications
- Publication Search
- Publication Details
Title
Hormone-sensitive lipase: sixty years later
Authors
Keywords
Hormone-sensitive lipase, lipids, lipolysis, lipodystrophy, obesity
Journal
PROGRESS IN LIPID RESEARCH
Volume 82, Issue -, Pages 101084
Publisher
Elsevier BV
Online
2020-12-30
DOI
10.1016/j.plipres.2020.101084
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Crystal structure of PMGL2 esterase from the hormone-sensitive lipase family with GCSAG motif around the catalytic serine
- (2020) Konstantin M. Boyko et al. PLoS One
- Characterization of a Novel Moderately Thermophilic Solvent-Tolerant Esterase Isolated From a Compost Metagenome Library
- (2020) Ji-Min Park et al. Frontiers in Microbiology
- Hormone-sensitive lipase is a retinyl ester hydrolase in human and rat quiescent hepatic stellate cells
- (2019) Shiva Shajari et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Discovery of FAHFA-Containing Triacylglycerols and Their Metabolic Regulation
- (2019) Dan Tan et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- An Epistatic Interaction between Pnpla2 and Lipe Reveals New Pathways of Adipose Tissue Lipolysis
- (2019) Xiao Zhang et al. Cells
- PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms
- (2019) Peng Zhou et al. JOURNAL OF CLINICAL INVESTIGATION
- Deficiency in hormone-sensitive lipase accelerates the development of pancreatic cancer in conditional KrasG12D mice
- (2018) Mu Xu et al. BMC CANCER
- The addition of the thermophilic esterase EST2 influences the fatty acids and volatile compound profiles of semi hard cheeses
- (2018) Valentina DE LUCA et al. Food Science and Technology
- Acceleration of Swiss cheese ripening by microbial lipase without affecting its quality characteristics
- (2018) Sapna Rani et al. JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
- Hepatic stellate cell activation and pro-fibrogenic signals
- (2017) Chandrashekhar R. Gandhi JOURNAL OF HEPATOLOGY
- Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease
- (2017) Matthias J. Betz et al. Nature Reviews Endocrinology
- The gibberellin GID1-DELLA signalling module exists in evolutionarily ancient conifers
- (2017) Ran Du et al. Scientific Reports
- The cAMP-PKA pathway-mediated fat mobilization is required for cold tolerance in C. elegans
- (2017) Fang Liu et al. Scientific Reports
- Epistatic interaction between the lipase-encoding genes Pnpla2 and Lipe causes liposarcoma in mice
- (2017) Jiang Wei Wu et al. PLoS Genetics
- Adipose tissue deficiency of hormone-sensitive lipase causes fatty liver in mice
- (2017) Bo Xia et al. PLoS Genetics
- The first description of a hormone-sensitive lipase from a basidiomycete: Structural insights and biochemical characterization revealed Bjerkandera adusta Ba EstB as a novel esterase
- (2017) María del Rayo Sánchez-Carbente et al. MicrobiologyOpen
- HomozygousLIPEmutation in siblings with multiple symmetric lipomatosis, partial lipodystrophy, and myopathy
- (2016) Sagit Zolotov et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Adipocyte lipolysis and insulin resistance
- (2016) Pauline Morigny et al. BIOCHIMIE
- Identification of a novel boronic acid as a potent, selective, and orally active hormone sensitive lipase inhibitor
- (2016) Tomoko Ogiyama et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Lipolytic enzymes involving lipolysis in Teleost: Synteny, structure, tissue distribution, and expression in grass carp (Ctenopharyngodon idella)
- (2016) Jian Sun et al. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
- Targeting protein–protein interactions, a wide open field for drug design
- (2016) May Bakail et al. COMPTES RENDUS CHIMIE
- A beta cell ATGL-lipolysis/adipose tissue axis controls energy homeostasis and body weight via insulin secretion in mice
- (2016) Camille Attané et al. DIABETOLOGIA
- Metabolic coupling in pancreatic beta cells: lipolysis revisited
- (2016) Hindrik Mulder DIABETOLOGIA
- Slowing down fat digestion and absorption by an oxadiazolone inhibitor targeting selectively gastric lipolysis
- (2016) Vanessa Point et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Two isoforms of hormone-sensitive lipase b are generated by alternative exons usage and transcriptional regulation by insulin in grass carp (Ctenopharyngodon idella)
- (2016) Jian Sun et al. FISH PHYSIOLOGY AND BIOCHEMISTRY
- AMPK Phosphorylates Desnutrin/ATGL and Hormone-Sensitive Lipase To Regulate Lipolysis and Fatty Acid Oxidation within Adipose Tissue
- (2016) Sun-Joong Kim et al. MOLECULAR AND CELLULAR BIOLOGY
- An AMP-activated protein kinase–stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice
- (2016) Maria Rohm et al. NATURE MEDICINE
- Inhibition of Monoacylglycerol Lipase Activity Decreases Glucose-Stimulated Insulin Secretion in INS-1 (832/13) Cells and Rat Islets
- (2016) Charles A. Berdan et al. PLoS One
- The elusive endogenous adipogenic PPARγ agonists: Lining up the suspects
- (2016) Philip Hallenborg et al. PROGRESS IN LIPID RESEARCH
- Structural insights of a hormone sensitive lipase homologue Est22
- (2016) Jing Huang et al. Scientific Reports
- Metagenomic mining for thermostable esterolytic enzymes uncovers a new family of bacterial esterases
- (2016) Dimitra Zarafeta et al. Scientific Reports
- Brown and Beige Fat: Physiological Roles beyond Heat Generation
- (2015) Shingo Kajimura et al. Cell Metabolism
- Fatty acids from fat cell lipolysis do not activate an inflammatory response but are stored as triacylglycerols in adipose tissue macrophages
- (2015) Sylvie Caspar-Bauguil et al. DIABETOLOGIA
- GSK256073 acutely regulates NEFA levels via HCA2 agonism but does not achieve durable glycaemic control in type 2 diabetes. A randomised trial
- (2015) Robert Dobbins et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Interdomain Hydrophobic Interactions Modulate the Thermostability of Microbial Esterases from the Hormone-Sensitive Lipase Family
- (2015) Ping-Yi Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Characterization of LipN (Rv2970c) ofMycobacterium TuberculosisH37Rv and its Probable Role in Xenobiotic Degradation
- (2015) Dipendrasinh Jadeja et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Structural insights into the substrate specificity of two esterases from the thermophilicRhizomucor miehei
- (2015) Shaoqing Yang et al. JOURNAL OF LIPID RESEARCH
- Simplified assays of lipolysis enzymes for drug discovery and specificity assessment of known inhibitors
- (2015) Jose Iglesias et al. JOURNAL OF LIPID RESEARCH
- SF-1 (NR5A1) expression is stimulated by the PKA pathway and is essential for the PKA-induced activation of LIPE expression in Y-1 cells
- (2015) K. Kulcenty et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Induction of hormone-sensitive lipase/cholesteryl esterase gene expression by C/EBPα independently of the PKA pathway in the adrenocortical Y-1 cells
- (2015) M.T. Czajkowski et al. STEROIDS
- How the Same Core Catalytic Machinery Catalyzes 17 Different Reactions: the Serine-Histidine-Aspartate Catalytic Triad of α/β-Hydrolase Fold Enzymes
- (2015) Alissa Rauwerdink et al. ACS Catalysis
- Cancer cachexia, mechanism and treatment
- (2015) Tomoyoshi Aoyagi et al. World Journal of Gastrointestinal Oncology
- A Novel LIPE Nonsense Mutation Found Using Exome Sequencing in Siblings With Late-Onset Familial Partial Lipodystrophy
- (2014) Sali M.K. Farhan et al. CANADIAN JOURNAL OF CARDIOLOGY
- Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects
- (2014) Mark M. Yore et al. CELL
- Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality
- (2014) Michelle R. Arkin et al. CHEMISTRY & BIOLOGY
- Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes
- (2014) Y. Li et al. EMBO REPORTS
- The Catalytic Function of Hormone-Sensitive Lipase is Essential for Fertility in Male Mice
- (2014) Shu Pei Wang et al. ENDOCRINOLOGY
- Characterization of an organic solvent-tolerant lipase from Haloarcula sp. G41 and its application for biodiesel production
- (2014) Xin Li et al. FOLIA MICROBIOLOGICA
- Secretion of fatty acid binding protein aP2 from adipocytes through a nonclassical pathway in response to adipocyte lipase activity
- (2014) Meric Erikci Ertunc et al. JOURNAL OF LIPID RESEARCH
- Characterization of a novel hormone-sensitive lipase family esterase from Rhizomucor miehei with tertiary alcohol hydrolysis activity
- (2014) Qiao-juan Yan et al. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
- Null Mutation in Hormone-Sensitive Lipase Gene and Risk of Type 2 Diabetes
- (2014) Jessica S. Albert et al. NEW ENGLAND JOURNAL OF MEDICINE
- Phospholipase C-Related Catalytically Inactive Protein (PRIP) Regulates Lipolysis in Adipose Tissue by Modulating the Phosphorylation of Hormone-Sensitive Lipase
- (2014) Toshiya Okumura et al. PLoS One
- Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance
- (2014) Peter Arner et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Increased De Novo Lipogenesis Is a Distinct Characteristic of Individuals With Nonalcoholic Fatty Liver Disease
- (2013) Jennifer E. Lambert et al. GASTROENTEROLOGY
- Mechanisms of Action of Hormone-sensitive Lipase in Mouse Leydig Cells
- (2013) Pulak R. Manna et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Contraction-induced lipolysis is not impaired by inhibition of hormone-sensitive lipase in skeletal muscle
- (2013) Thomas J. Alsted et al. JOURNAL OF PHYSIOLOGY-LONDON
- Development of small-molecule inhibitors targeting adipose triglyceride lipase
- (2013) Nicole Mayer et al. Nature Chemical Biology
- Partial Inhibition of Adipose Tissue Lipolysis Improves Glucose Metabolism and Insulin Sensitivity Without Alteration of Fat Mass
- (2013) Amandine Girousse et al. PLOS BIOLOGY
- Cholesteryl ester accumulation and accelerated cholesterol absorption in intestine-specific hormone sensitive lipase-null mice
- (2012) Sascha Obrowsky et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Mechanisms for Insulin Resistance: Common Threads and Missing Links
- (2012) Varman T. Samuel et al. CELL
- Fatty Acids Change the Conformation of Uncoupling Protein 1 (UCP1)
- (2012) Ajit S. Divakaruni et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism
- (2012) Mark A. Herman et al. NATURE
- MmPPOX Inhibits Mycobacterium tuberculosis Lipolytic Enzymes Belonging to the Hormone-Sensitive Lipase Family and Alters Mycobacterial Growth
- (2012) Vincent Delorme et al. PLoS One
- Comprehensive analysis of surface charged residues involved in thermal stability in Alicyclobacillus acidocaldarius esterase 2
- (2012) M. Pezzullo et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Thermostable Esterase 2 fromAlicyclobacillus acidocaldariusas Biosensor for the Detection of Organophosphate Pesticides
- (2011) Ferdinando Febbraio et al. ANALYTICAL CHEMISTRY
- Identification of a new subfamily of salt-tolerant esterases from a metagenomic library of tidal flat sediment
- (2011) Jeong Ho Jeon et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- The molecular mechanism of human hormone-sensitive lipase inhibition by substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones
- (2011) Yassine Ben Ali et al. BIOCHIMIE
- Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype
- (2011) Maryam Ahmadian et al. Cell Metabolism
- Fatty Acids, Obesity, and Insulin Resistance: Time for a Reevaluation
- (2011) F. Karpe et al. DIABETES
- Hormone-sensitive lipase-knockout mice maintain high bone density during aging
- (2011) Wen-Jun Shen et al. FASEB JOURNAL
- Monoglyceride Lipase Deficiency in Mice Impairs Lipolysis and Attenuates Diet-induced Insulin Resistance
- (2011) Ulrike Taschler et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A new twist in the function of the cardiac lipid droplet
- (2011) E Dale Abel NATURE MEDICINE
- Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia
- (2011) S. K. Das et al. SCIENCE
- The hormone-sensitive lipase from Psychrobacter sp. TA144: New insight in the structural/functional characterization
- (2010) Concetta De Santi et al. BIOCHIMIE
- Prospective association between fasting NEFA and type 2 diabetes: impact of post-load glucose
- (2010) D. Il’yasova et al. DIABETOLOGIA
- B56α/Protein Phosphatase 2A Inhibits Adipose Lipolysis in High-Fat Diet-Induced Obese Mice
- (2010) Brice P. Kinney et al. ENDOCRINOLOGY
- Cholesteryl ester hydrolase activity is abolished in HSL macrophages but unchanged in macrophages lacking KIAA1363
- (2010) Marlene Buchebner et al. JOURNAL OF LIPID RESEARCH
- Vimentin Is a Functional Partner of Hormone Sensitive Lipase And Facilitates Lipolysis
- (2010) Wen-Jun Shen et al. JOURNAL OF PROTEOME RESEARCH
- Quarternary Structure and Enzymological Properties of the Different Hormone-Sensitive Lipase (HSL) Isoforms
- (2010) Christian Krintel et al. PLoS One
- Adipose triacylglycerol lipase deletion alters whole body energy metabolism and impairs exercise performance in mice
- (2009) Elisabeth Huijsman et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- First evidence for the salt-dependent folding and activity of an esterase from the halophilic archaea Haloarcula marismortui
- (2009) Marcelo Müller-Santos et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- In vitro stereoselective hydrolysis of diacylglycerols by hormone-sensitive lipase
- (2009) Jorge A. Rodriguez et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Rapid, specific and sensitive electrochemical detection of foodborne bacteria
- (2009) Christopher Pöhlmann et al. BIOSENSORS & BIOELECTRONICS
- Ablation of Neutral Cholesterol Ester Hydrolase 1 Accelerates Atherosclerosis
- (2009) Motohiro Sekiya et al. Cell Metabolism
- PKA phosphorylates and inactivates AMPKα to promote efficient lipolysis
- (2009) Nabil Djouder et al. EMBO JOURNAL
- Hormone-sensitive lipase (HSL) is also a retinyl ester hydrolase: evidence from mice lacking HSL
- (2009) Kristoffer Ström et al. FASEB JOURNAL
- Phosphorylation of hormone-sensitive lipase by protein kinase A in vitro promotes an increase in its hydrophobic surface area
- (2009) Christian Krintel et al. FEBS Journal
- Activation of Hormone-sensitive Lipase Requires Two Steps, Protein Phosphorylation and Binding to the PAT-1 Domain of Lipid Droplet Coat Proteins
- (2009) Hong Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lipolysis and lipid mobilization in human adipose tissue
- (2009) Max Lafontan et al. PROGRESS IN LIPID RESEARCH
- Mining the genome sequence for novel enzyme activity: characterisation of an unusual member of the hormone-sensitive lipase family of esterases from the genome of Streptomyces coelicolor A3 (2)
- (2009) Sameh H. Soror et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Hormone-sensitive lipase is necessary for normal mobilization of lipids during submaximal exercise
- (2008) Céline Fernandez et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Cardiac overexpression of hormone-sensitive lipase inhibits myocardial steatosis and fibrosis in streptozotocin diabetic mice
- (2008) Masami Ueno et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Adipose triglyceride lipase in human skeletal muscle is upregulated by exercise training
- (2008) Thomas J. Alsted et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Lack of cholesterol mobilization in islets of hormone-sensitive lipase deficient mice impairs insulin secretion
- (2008) Sara Larsson et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Lipolysis-Not inflammation, cell death, or lipogenesis-Is involved in adipose tissue loss in cancer cachexia
- (2008) Mikael Rydén et al. CANCER
- Cachexia: prevalence and impact in medicine
- (2008) Benjamin HL Tan et al. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
- A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis
- (2008) M. Fex et al. DIABETOLOGIA
- Adipose triglyceride lipase (ATGL) expression in human skeletal muscle is type I (oxidative) fiber specific
- (2008) Johan W. E. Jocken et al. HISTOCHEMISTRY AND CELL BIOLOGY
- Hormone-sensitive lipase is involved in hepatic cholesteryl ester hydrolysis
- (2008) Motohiro Sekiya et al. JOURNAL OF LIPID RESEARCH
- A Functional Interaction between RIP140 and PGC-1 Regulates the Expression of the Lipid Droplet Protein CIDEA
- (2008) M. Hallberg et al. MOLECULAR AND CELLULAR BIOLOGY
- Ser649 and Ser650 Are the Major Determinants of Protein Kinase A-Mediated Activation of Human Hormone-Sensitive Lipase against Lipid Substrates
- (2008) Christian Krintel et al. PLoS One
- Alterations in the testis of hormone sensitive lipase-deficient mice is associated with decreased sperm counts, sperm motility, and fertility
- (2007) Louis Hermo et al. MOLECULAR REPRODUCTION AND DEVELOPMENT
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started