The role of adipose triglyceride lipase in lipid and glucose homeostasis: lessons from transgenic mice

Pharmacological intervention of liver triacylglycerol lipolysis: The good, the bad and the ugly

(2018) Ariel D. Quiroga et al.   BIOCHEMICAL PHARMACOLOGY

Genetically modified mouse models to study hepatic neutral lipid mobilization

(2018) Guenter Haemmerle et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice

(2018) Markus Heine et al.   Cell Metabolism

Skeletal muscle inflammation and insulin resistance in obesity

(2017) Huaizhu Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance

(2017) Max C. Petersen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice

(2017) Martina Schweiger et al.   Nature Communications

Lipid metabolism and signaling in cardiac lipotoxicity

(2016) Kenneth D'Souza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A beta cell ATGL-lipolysis/adipose tissue axis controls energy homeostasis and body weight via insulin secretion in mice

(2016) Camille Attané et al.   DIABETOLOGIA

PPARα-ATGL pathway improves muscle mitochondrial metabolism: implication in aging

(2016) Dipsikha Biswas et al.   FASEB JOURNAL

ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle

(2015) Ruth C. R. Meex et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adipose triglyceride lipase deletion from adipocytes, but not skeletal myocytes, impairs acute exercise performance in mice

(2015) John J. Dubé et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling

(2015) Salmaan Ahmed Khan et al.   DIABETES

Impact of Reduced ATGL-Mediated Adipocyte Lipolysis on Obesity-Associated Insulin Resistance and Inflammation in Male Mice

(2015) Gabriele Schoiswohl et al.   ENDOCRINOLOGY

Simplified assays of lipolysis enzymes for drug discovery and specificity assessment of known inhibitors

(2015) Jose Iglesias et al.   JOURNAL OF LIPID RESEARCH

Ceramides – Lipotoxic Inducers of Metabolic Disorders

(2015) Bhagirath Chaurasia et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis

(2015) Chiara Saponaro et al.   Nutrients

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

Early structural and metabolic cardiac remodelling in response to inducible adipose triglyceride lipase ablation

(2013) Petra C. Kienesberger et al.   CARDIOVASCULAR RESEARCH

Desnutrin/ATGL Activates PPARδ to Promote Mitochondrial Function for Insulin Secretion in Islet β Cells

(2013) Tianyi Tang et al.   Cell Metabolism

Myocardial Adipose Triglyceride Lipase Overexpression Protects Diabetic Mice From the Development of Lipotoxic Cardiomyopathy

(2013) T. Pulinilkunnil et al.   DIABETES

Skeletal Muscle Triacylglycerol Hydrolysis Does Not Influence Metabolic Complications of Obesity

(2013) M. T. Sitnick et al.   DIABETES

High-Fat Diet-Mediated Lipotoxicity and Insulin Resistance Is Related to Impaired Lipase Expression in Mouse Skeletal Muscle

(2013) Pierre-Marie Badin et al.   ENDOCRINOLOGY

Cardiomyocyte specific adipose triglyceride lipase overexpression prevents doxorubicin induced cardiac dysfunction in female mice

(2013) Jeevan Nagendran et al.   HEART

Development of small-molecule inhibitors targeting adipose triglyceride lipase

(2013) Nicole Mayer et al.   Nature Chemical Biology

CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance

(2013) J. L. Cantley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

(2012) Rudolf Zechner et al.   Cell Metabolism

Fasting Energy Homeostasis in Mice with Adipose Deficiency of Desnutrin/Adipose Triglyceride Lipase

(2012) Jiang Wei Wu et al.   ENDOCRINOLOGY

PPARs: Fatty acid sensors controlling metabolism

(2012) Lars la Cour Poulsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Trends in carbohydrate, fat, and protein intakes and association with energy intake in normal-weight, overweight, and obese individuals: 1971–2006

(2011) Gregory L Austin et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype

(2011) Maryam Ahmadian et al.   Cell Metabolism

Altered Skeletal Muscle Lipase Expression and Activity Contribute to Insulin Resistance in Humans

(2011) P.-M. Badin et al.   DIABETES

Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis

(2011) Jiang Wei Wu et al.   HEPATOLOGY

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

(2011) Guenter Haemmerle et al.   NATURE MEDICINE

Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice

(2010) S. M. Turpin et al.   DIABETOLOGIA

Adipose Triglyceride Lipase-Null Mice Are Resistant to High-Fat Diet–Induced Insulin Resistance Despite Reduced Energy Expenditure and Ectopic Lipid Accumulation

(2010) Andrew J. Hoy et al.   ENDOCRINOLOGY

Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning

(2010) Kuok Teong Ong et al.   HEPATOLOGY

Adipose triacylglycerol lipase deletion alters whole body energy metabolism and impairs exercise performance in mice

(2009) Elisabeth Huijsman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5

(2009) Martina Schweiger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Molecular and Metabolic Evidence for Mitochondrial Defects Associated With  -Cell Dysfunction in a Mouse Model of Type 2 Diabetes

(2009) H. Lu et al.   DIABETES

Adipose Overexpression of Desnutrin Promotes Fatty Acid Use and Attenuates Diet-Induced Obesity

(2009) M. Ahmadian et al.   DIABETES

Improved insulin sensitivity and islet function after PPARδ activation in diabetic db/db mice

(2009) Maria Sörhede Winzell et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Adipose Triglyceride Lipase Deficiency Causes Tissue-specific Changes in Insulin Signaling

(2009) Petra C. Kienesberger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipose Triglyceride Lipase Is Implicated in Fuel- and Non-fuel-stimulated Insulin Secretion

(2009) Marie-Line Peyot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPARδ is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction

(2009) Kim Ravnskjaer et al.   JOURNAL OF LIPID RESEARCH

Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids

(2009) Gabriele Schoiswohl et al.   JOURNAL OF LIPID RESEARCH

Fate of fat: The role of adipose triglyceride lipase in lipolysis

(2008) Robert Zimmermann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Hepatic Overexpression of Hormone-sensitive Lipase and Adipose Triglyceride Lipase Promotes Fatty Acid Oxidation, Stimulates Direct Release of Free Fatty Acids, and Ameliorates Steatosis

(2008) Brendan N. Reid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores

(2008) Rudolf Zechner et al.   JOURNAL OF LIPID RESEARCH

Reduced hepatic expression of adipose tissue triglyceride lipase and CGI-58 may contribute to the development of non-alcoholic fatty liver disease in patients with insulin resistance

(2008) Masaki Kato et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY