Defining the underlying defect in insulin action in type 2 diabetes

Arrestin domain-containing 3 (Arrdc3) modulates insulin action and glucose metabolism in liver

(2020) Thiago M. Batista et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism

(2020) Kristine Williams et al.   Nature Communications

Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis

(2020) Marijana Vujkovic et al.   NATURE GENETICS

A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes

(2020) Thiago M. Batista et al.   Cell Metabolism

A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance

(2020) Kun Lyu et al.   Cell Metabolism

Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo

(2019) Thiago M. Batista et al.   Cell Reports

FOXK1 and FOXK2 regulate aerobic glycolysis

(2019) Valentina Sukonina et al.   NATURE

Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression

(2019) Melissa L. Hancock et al.   CELL

PI3K isoforms in cell signalling and vesicle trafficking

(2019) Benoit Bilanges et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes

(2019) Irene Miguel-Escalada et al.   NATURE GENETICS

FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism

(2019) Masaji Sakaguchi et al.   Nature Communications

Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study

(2019) Oana P Zaharia et al.   Lancet Diabetes & Endocrinology

Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor–ligand complex

(2019) Emiko Uchikawa et al.   eLife

The integrative biology of type 2 diabetes

(2019) Michael Roden et al.   NATURE

Distinct signalling properties of insulin receptor substrate (IRS)-1 and IRS-2 in mediating insulin/IGF-1 action

(2018) Atefeh Rabiee et al.   CELLULAR SIGNALLING

mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation

(2018) Long He et al.   MOLECULAR CELL

Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis

(2018) Giovanna Scapin et al.   NATURE

Circulating Exosomal miR-20b-5p is Elevated in Type 2 Diabetes and Could Impair Insulin Action in Human Skeletal Muscle

(2018) Mutsumi Katayama et al.   DIABETES

FoxO Transcription Factors are Critical Regulators of Diabetes-Related Muscle Atrophy

(2018) Brian T. O’Neill et al.   DIABETES

MicroRNAs as Regulators of Insulin Signaling: Research Updates and Potential Therapeutic Perspectives in Type 2 Diabetes

(2018) Laura Nigi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Insulin Receptor Isoforms in Physiology and Disease: An Updated View

(2017) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Restoration of metabolic health by decreased consumption of branched-chain amino acids

(2017) Nicole E. Cummings et al.   JOURNAL OF PHYSIOLOGY-LONDON

Adipose-derived circulating miRNAs regulate gene expression in other tissues

(2017) Thomas Thomou et al.   NATURE

The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue

(2017) Matthew D Lynes et al.   NATURE MEDICINE

Global aetiology and epidemiology of type 2 diabetes mellitus and its complications

(2017) Yan Zheng et al.   Nature Reviews Endocrinology

SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology

(2017) Hitoshi Shimano et al.   Nature Reviews Endocrinology

Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression

(2017) Weikang Cai et al.   Nature Communications

Dysregulation of a novel miR-23b/27b-p53 axis impairs muscle stem cell differentiation of humans with type 2 diabetes

(2017) Tora I. Henriksen et al.   Molecular Metabolism

Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction

(2016) Junli Liu et al.   CELL

Mitotic Checkpoint Regulators Control Insulin Signaling and Metabolic Homeostasis

(2016) Eunhee Choi et al.   CELL

Integrative Transcriptome Analyses of Metabolic Responses in Mice Define Pivotal LncRNA Metabolic Regulators

(2016) Ling Yang et al.   Cell Metabolism

Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis

(2016) Brian T. O’Neill et al.   JOURNAL OF CLINICAL INVESTIGATION

Linking Gut Microbiota and Inflammation to Obesity and Insulin Resistance

(2016) M. J. A. Saad et al.   PHYSIOLOGY

Myotubes derived from human-induced pluripotent stem cells mirror in vivo insulin resistance

(2016) Salvatore Iovino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin Resistance in Human iPS Cells Reduces Mitochondrial Size and Function

(2016) Alison M. Burkart et al.   Scientific Reports

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Role of PKCδ in Insulin Sensitivity and Skeletal Muscle Metabolism

(2015) Mengyao Li et al.   DIABETES

High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics

(2015) Sean J Humphrey et al.   NATURE BIOTECHNOLOGY

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization

(2015) InSug O-Sullivan et al.   Nature Communications

Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

(2014) Mark M. Yore et al.   CELL

Genetic Insulin Resistance Is a Potent Regulator of Gene Expression and Proliferation in Human iPS Cells

(2014) S. Iovino et al.   DIABETES

Diabetes Mellitus: Its differentiation into insulin-sensitive and insulin-insensitive types

(2014) H. Himsworth   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors

(2014) Rebecca A. Haeusler et al.   Nature Communications

Epigenetic Rejuvenation of Mesenchymal Stromal Cells Derived from Induced Pluripotent Stem Cells

(2014) Joana Frobel et al.   Stem Cell Reports

The Origins and Drivers of Insulin Resistance

(2013) Andrew M.F. Johnson et al.   CELL

Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2

(2013) Sean J. Humphrey et al.   Cell Metabolism

Derivation of Human Induced Pluripotent Stem Cells from Patients with Maturity Onset Diabetes of the Young

(2013) Adrian K. K. Teo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

(2012) Christopher K. Glass et al.   Cell Metabolism

Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin Resistance

(2012) Christopher B. Newgard   Cell Metabolism

Glypican-4 Enhances Insulin Signaling via Interaction With the Insulin Receptor and Serves as a Novel Adipokine

(2012) S. Ussar et al.   DIABETES

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

(2012) Alisa K Manning et al.   NATURE GENETICS

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

(2012) Mingjian Lu et al.   NATURE MEDICINE

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

Genome-Wide Analysis of DNA Methylation Differences in Muscle and Fat from Monozygotic Twins Discordant for Type 2 Diabetes

(2012) Rasmus Ribel-Madsen et al.   PLoS One

JNK2 is activated during ER stress and promotes cell survival

(2012) M Raciti et al.   Cell Death & Disease

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Expression of the Splicing Factor Gene SFRS10 Is Reduced in Human Obesity and Contributes to Enhanced Lipogenesis

(2011) Jussi Pihlajamäki et al.   Cell Metabolism

Adipose tissue remodeling and obesity

(2011) Kai Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Non-CpG Methylation of the PGC-1α Promoter through DNMT3B Controls Mitochondrial Density

(2009) Romain Barrès et al.   Cell Metabolism

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Kinetics of GLUT4 Trafficking in Rat and Human Skeletal Muscle

(2009) H. K.R. Karlsson et al.   DIABETES

Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization

(2009) D. D. Sears et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients

(2008) D. Cozzone et al.   DIABETOLOGIA