Gene Delivery of a Caspase Activation and Recruitment Domain Improves Retinal Pigment Epithelial Function and Modulates Inflammation in a Mouse Model with Features of Dry Age-Related Macular Degeneration
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Gene Delivery of a Caspase Activation and Recruitment Domain Improves Retinal Pigment Epithelial Function and Modulates Inflammation in a Mouse Model with Features of Dry Age-Related Macular Degeneration
Authors
Keywords
-
Journal
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
Volume -, Issue -, Pages -
Publisher
Mary Ann Liebert Inc
Online
2022-04-21
DOI
10.1089/jop.2022.0002
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Nuclear Receptors in the Control of the NLRP3 Inflammasome Pathway
- (2021) Hélène Duez et al. Frontiers in Endocrinology
- Emerging therapies and their delivery for treating age‐related macular degeneration
- (2021) Chloe N. Thomas et al. BRITISH JOURNAL OF PHARMACOLOGY
- Age-related macular degeneration
- (2021) Monika Fleckenstein et al. Nature Reviews Disease Primers
- Intravitreal Gene Therapy vs. Natural History in Patients With Leber Hereditary Optic Neuropathy Carrying the m.11778G>A ND4 Mutation: Systematic Review and Indirect Comparison
- (2021) Nancy J. Newman et al. Frontiers in Neurology
- Contribution of microglia and monocytes to the development and progression of age related macular degeneration
- (2020) Erica L Fletcher OPHTHALMIC AND PHYSIOLOGICAL OPTICS
- Microglia versus Monocytes: Distinct Roles in Degenerative Diseases of the Retina
- (2020) Chen Yu et al. TRENDS IN NEUROSCIENCES
- Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy
- (2020) Patrick Yu-Wai-Man et al. Science Translational Medicine
- The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation
- (2019) Nathan Kelley et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Expression of a CARD Slows the Retinal Degeneration of a Geographic Atrophy Mouse Model
- (2019) Brianna M. Young et al. Molecular Therapy-Methods & Clinical Development
- Prevalence and incidence of age-related macular degeneration in Europe: a systematic review and meta-analysis
- (2019) Jeany Q Li et al. BRITISH JOURNAL OF OPHTHALMOLOGY
- Suppression of aberrant choroidal neovascularization through activation of the aryl hydrocarbon receptor
- (2018) Mayur Choudhary et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Evidence for the activation of pyroptotic and apoptotic pathways in RPE cells associated with NLRP3 inflammasome in the rodent eye
- (2018) Jiangyuan Gao et al. Journal of Neuroinflammation
- Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
- (2018) Luigi Ferrucci et al. Nature Reviews Cardiology
- Issues with the Specificity of Immunological Reagents for NLRP3: Implications for Age-related Macular Degeneration
- (2018) Cassandra Kosmidou et al. Scientific Reports
- Genetics of age-related macular degeneration (AMD)
- (2017) Margaret M. DeAngelis et al. HUMAN MOLECULAR GENETICS
- Microglia-derived IL-1β promotes chemokine expression by Müller cells and RPE in focal retinal degeneration
- (2017) Riccardo Natoli et al. Molecular Neurodegeneration
- PPARβ/δ selectively regulates phenotypic features of age-related macular degeneration
- (2016) Mayur Choudhary et al. Aging-US
- NLRP3 inflammasome activation mediates estrogen deficiency-induced depression- and anxiety-like behavior and hippocampal inflammation in mice
- (2016) Yongjun Xu et al. BRAIN BEHAVIOR AND IMMUNITY
- Cellular GFP Toxicity and Immunogenicity: Potential Confounders in in Vivo Cell Tracking Experiments
- (2016) Amir Mehdi Ansari et al. Stem Cell Reviews and Reports
- Cellular GFP Toxicity and Immunogenicity: Potential Confounders in in Vivo Cell Tracking Experiments
- (2016) Amir Mehdi Ansari et al. Stem Cell Reviews and Reports
- Inflammasomes Induced by 7-Ketocholesterol and Other Stimuli in RPE and in Bone Marrow-Derived Cells Differ Markedly in Their Production of IL-1 and IL-18
- (2015) G. Shi et al. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
- Chemokine-mediated inflammation in the degenerating retina is coordinated by Müller cells, activated microglia, and retinal pigment epithelium
- (2015) Matt Rutar et al. Journal of Neuroinflammation
- NLRP3 Inflammasome: Activation and Regulation in Age-Related Macular Degeneration
- (2015) Jiangyuan Gao et al. MEDIATORS OF INFLAMMATION
- Gene Therapy With the Caspase Activation and Recruitment Domain Reduces the Ocular Inflammatory Response
- (2015) Cristhian J Ildefonso et al. MOLECULAR THERAPY
- Interleukin-1β Level Is Increased in Vitreous of Patients with Neovascular Age-Related Macular Degeneration (nAMD) and Polypoidal Choroidal Vasculopathy (PCV)
- (2015) Min Zhao et al. PLoS One
- Aryl hydrocarbon receptor knock-out exacerbates choroidal neovascularization via multiple pathogenic pathways
- (2014) Mayur Choudhary et al. JOURNAL OF PATHOLOGY
- CCR2+monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation inCx3cr1deficient mice
- (2013) Florian Sennlaub et al. EMBO Molecular Medicine
- The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina
- (2013) Allen R. Rodriguez et al. JOURNAL OF COMPARATIVE NEUROLOGY
- A2E Induces IL-1ß Production in Retinal Pigment Epithelial Cells via the NLRP3 Inflammasome
- (2013) Owen A. Anderson et al. PLoS One
- Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology
- (2013) P. Hu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88
- (2012) Valeria Tarallo et al. CELL
- Characterization of retinal expression of vascular cell adhesion molecule (VCAM-1) during experimental autoimmune uveitis
- (2012) M. Makhoul et al. EXPERIMENTAL EYE RESEARCH
- Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells—Implications for age-related macular degeneration (AMD)
- (2012) Anu Kauppinen et al. IMMUNOLOGY LETTERS
- NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components
- (2012) Sarah L Doyle et al. NATURE MEDICINE
- Evaluation of variants in the selectin genes in age-related macular degeneration
- (2011) Robert F Mullins et al. BMC Medical Genetics
- The inflammasome: an integrated view
- (2011) Olaf Gross et al. IMMUNOLOGICAL REVIEWS
- Gene therapy with a promoter targeting both rods and cones rescues retinal degeneration caused by AIPL1 mutations
- (2009) X Sun et al. GENE THERAPY
- Intravitreal delivery of AAV8 retinoschisin results in cell type-specific gene expression and retinal rescue in the Rs1-KO mouse
- (2009) T K Park et al. GENE THERAPY
- The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis
- (2009) Luigi Franchi et al. NATURE IMMUNOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search