Evidence for the activation of pyroptotic and apoptotic pathways in RPE cells associated with NLRP3 inflammasome in the rodent eye

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

Inflammasome Involvement in Alzheimer’s Disease

(2016) Ingar Olsen et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid β induces NLRP3 inflammasome activation in retinal pigment epithelial cells via NADPH oxidase- and mitochondria-dependent ROS production

(2016) Ke Wang et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Defining response to anti-VEGF therapies in neovascular AMD

(2015) W M Amoaku et al.   EYE

Age-related increases in amyloid beta and membrane attack complex: evidence of inflammasome activation in the rodent eye

(2015) Tom Zhao et al.   Journal of Neuroinflammation

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

NLRP3 Inflammasome and Pathobiology in AMD

(2015) Lucia Celkova et al.   Journal of Clinical Medicine

Vinpocetine inhibits amyloid-beta induced activation of NF-κB, NLRP3 inflammasome and cytokine production in retinal pigment epithelial cells

(2014) Ruozhou Tom Liu et al.   EXPERIMENTAL EYE RESEARCH

IL-18 is not therapeutic for neovascular age-related macular degeneration

(2014) Yoshio Hirano et al.   NATURE MEDICINE

DICER1/AluRNA dysmetabolism induces Caspase-8–mediated cell death in age-related macular degeneration

(2014) Younghee Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration

(2014) S. L. Doyle et al.   Science Translational Medicine

Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis

(2014) Wan Ling Wong et al.   Lancet Global Health

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

(2013) V Sagulenko et al.   CELL DEATH AND DIFFERENTIATION

A2E Induces IL-1ß Production in Retinal Pigment Epithelial Cells via the NLRP3 Inflammasome

(2013) Owen A. Anderson et al.   PLoS One

Alternative Complement Pathway Deficiency Ameliorates Chronic Smoke-Induced Functional and Morphological Ocular Injury

(2013) Alex Woodell et al.   PLoS One

Aging is not a disease: Distinguishing age-related macular degeneration from aging

(2013) Daniel Ardeljan et al.   PROGRESS IN RETINAL AND EYE RESEARCH

DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88

(2012) Valeria Tarallo et al.   CELL

Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells—Implications for age-related macular degeneration (AMD)

(2012) Anu Kauppinen et al.   IMMUNOLOGY LETTERS

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

(2012) Sarah L Doyle et al.   NATURE MEDICINE

Distinct Licensing of IL-18 and IL-1β Secretion in Response to NLRP3 Inflammasome Activation

(2012) Rebecca L. Schmidt et al.   PLoS One

Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks

(2012) Aaron M Newman et al.   Genome Medicine

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

(2011) Hiroki Kaneko et al.   NATURE

Transformation of amyloid β(1–40) oligomers into fibrils is characterized by a major change in secondary structure

(2010) Rabia Sarroukh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Viewing Ageing Eyes: Diverse Sites of Amyloid Beta Accumulation in the Ageing Mouse Retina and the Up-Regulation of Macrophages

(2010) Jaimie Hoh Kam et al.   PLoS One

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Amyloid-β oligomers set fire to inflammasomes and induce Alzheimer's pathology

(2008) Antero Salminen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY